hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06680
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PHKA2 | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | UniProt NCBI |
| MPPED1 | Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) | UniProt NCBI |
| PHKA1 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | UniProt NCBI |
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26) | UniProt NCBI |
| CEP85L | Centrosomal protein of 85 kDa-like (Serologically defined breast cancer antigen NY-BR-15) | UniProt NCBI |
| PHKB | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | UniProt NCBI |
| PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-70221 | 1.15069612366e-12 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | Glycogen breakdown (glycogenolysis) |
| REAC:R-HSA-8982491 | 3.77577908797e-11 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | Glycogen metabolism |
| WP:WP500 | 9.15219634101e-11 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | Glycogen Synthesis and Degradation |
| GO:0005980 | 7.50504170437e-10 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | glycogen catabolic process |
| GO:0004689 | 8.5384464732e-10 | 0.571428571429 | PHKB PHKA1 PHKA2 PHKG2 | phosphorylase kinase activity |
| GO:0005964 | 8.5384464732e-10 | 0.571428571429 | PHKB PHKA1 PHKA2 PHKG2 | phosphorylase kinase complex |
| GO:0044247 | 1.0630951546e-09 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | cellular polysaccharide catabolic process |
| GO:0000272 | 1.0630951546e-09 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | polysaccharide catabolic process |
| GO:0009251 | 1.0630951546e-09 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | glucan catabolic process |
| CORUM:6640 | 3.38154272427e-09 | 0.428571428571 | PHKG1 PHKB PHKA1 | Phosphorylase kinase complex |
| KEGG:04922 | 1.09102378902e-08 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | Glucagon signaling pathway |
| GO:0044275 | 2.91448618104e-08 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | cellular carbohydrate catabolic process |
| KEGG:04910 | 4.17258087913e-08 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | Insulin signaling pathway |
| KEGG:04020 | 1.40853474206e-07 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | Calcium signaling pathway |
| GO:0005977 | 2.93152329112e-07 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | glycogen metabolic process |
| GO:0044042 | 3.26428463825e-07 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | glucan metabolic process |
| GO:0006073 | 3.26428463825e-07 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | cellular glucan metabolic process |
| GO:0006112 | 5.41068134386e-07 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | energy reserve metabolic process |
| GO:0044264 | 1.3030002824e-06 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | cellular polysaccharide metabolic process |
| GO:0005976 | 2.06696589169e-06 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | polysaccharide metabolic process |
| REAC:R-HSA-71387 | 5.5335670127e-06 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | Metabolism of carbohydrates |
| GO:0004683 | 1.07646157797e-05 | 0.571428571429 | PHKB PHKA1 PHKA2 PHKG2 | calmodulin-dependent protein kinase activity |
| GO:0016052 | 0.000114360178043 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | carbohydrate catabolic process |
| GO:0044262 | 0.000157091590794 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | cellular carbohydrate metabolic process |
| GO:0015980 | 0.00042674062621 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | energy derivation by oxidation of organic compounds |
| GO:1902554 | 0.000971413809773 | 0.571428571429 | PHKB PHKA1 PHKA2 PHKG2 | serine/threonine protein kinase complex |
| GO:1902911 | 0.00196423913453 | 0.571428571429 | PHKB PHKA1 PHKA2 PHKG2 | protein kinase complex |
| GO:0006091 | 0.00992616403577 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | generation of precursor metabolites and energy |
| GO:0005975 | 0.010884499893 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | carbohydrate metabolic process |
| GO:0055114 | 0.0254241642855 | 0.714285714286 | PHKG1 PHKB PHKA1 PHKA2 PHKG2 | oxidation-reduction process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PHKA2 | PHKG2 | 1.0 | 0.949 | hein_WMM bioplex (PHKG2) bioplex_WMM hein (PHKG2) |
| PHKG2 | PHKA1 | 1.0 | 0.949 | hein_WMM bioplex (PHKG2) bioplex_WMM hein (PHKG2) boldt_WMM |
| PHKB | PHKG2 | 1.0 | 0.949 | hein_WMM bioplex (PHKG2) bioplex_WMM hein (PHKG2) boldt_WMM |
| PHKG2 | PHKG1 | 0.991 | 0.909 | bioplex (PHKG2) |
| PHKA2 | MPPED1 | 0.986 | 0.901 | bioplex (MPPED1) bioplex_WMM |
| PHKB | MPPED1 | 0.895 | 0.821 | bioplex (MPPED1) bioplex_WMM |
| PHKA1 | MPPED1 | 0.395 | 0.555 | bioplex (MPPED1) bioplex_WMM |
| PHKG2 | MPPED1 | 0.317 | 0.509 | bioplex (MPPED1) bioplex_WMM |
| CEP85L | PHKG2 | 0.046 | 0.292 | bioplex (PHKG2) boldt boldt_WMM |
| PHKA2 | PHKB | 0.017 | 0.174 | hein_WMM bioplex_WMM WMM_only |
| PHKB | PHKA1 | 0.011 | 0.143 | hein_WMM bioplex_WMM youn_WMM WMM_only boldt_WMM |
| PHKA2 | PHKA1 | 0.01 | 0.131 | hein_WMM bioplex_WMM WMM_only |
| PHKA2 | PHKG1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| CEP85L | PHKG1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| CEP85L | PHKA1 | 0.008 | 0.085 | bioplex_WMM gupta_WMM WMM_only boldt_WMM |
| PHKB | PHKG1 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| PHKA1 | PHKG1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CEP85L | PHKB | 0.008 | 0.088 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| CEP85L | PHKA2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06680 has an average edge precision of 0.414 which is ranked 3166 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PHKA2 | HuMAP2_00680 HuMAP2_05857 HuMAP2_06680 |
| MPPED1 | HuMAP2_00680 HuMAP2_06680 |
| PHKA1 | HuMAP2_00680 HuMAP2_05335 HuMAP2_06680 |
| PHKG1 | HuMAP2_00680 HuMAP2_05335 HuMAP2_06680 |
| CEP85L | HuMAP2_00674 HuMAP2_03219 HuMAP2_05299 HuMAP2_06048 HuMAP2_06680 |
| PHKB | HuMAP2_00680 HuMAP2_06680 |
| PHKG2 | HuMAP2_00680 HuMAP2_05335 HuMAP2_06680 |