hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06682
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WRN | Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2) | UniProt NCBI |
| PAXX | Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein) | UniProt NCBI |
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | UniProt NCBI |
| PCID2 | PCI domain-containing protein 2 (CSN12-like protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4082 | 1.50819606993e-05 | 0.5 | WRN XRCC6 | XRCC6-XRCC5-WRN complex |
| CORUM:5235 | 3.01612206104e-05 | 0.5 | WRN XRCC6 | WRN-Ku70-Ku80-PARP1 complex |
| GO:0043564 | 0.00811409485621 | 0.5 | XRCC6 PAXX | Ku70:Ku80 complex |
| CORUM:328 | 0.0499140284799 | 0.25 | XRCC6 | Ku antigen complex |
| CORUM:1217 | 0.0499140284799 | 0.25 | WRN | WRN-TRF2 complex |
| CORUM:4081 | 0.0499140284799 | 0.25 | XRCC6 | Ku antigen complex |
| CORUM:7282 | 0.0499140284799 | 0.25 | WRN | FEN1-WRN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC6 | WRN | 0.999 | 0.949 | hein_WMM bioplex (XRCC6) bioplex_WMM boldt youn_WMM hein (XRCC6) boldt_WMM |
| XRCC6 | PAXX | 0.03 | 0.233 | hein_WMM hein (XRCC6) boldt_WMM |
| XRCC6 | PCID2 | 0.025 | 0.211 | bioplex_WMM youn_WMM gupta_WMM fraction |
| WRN | PAXX | 0.008 | 0.083 | hein_WMM WMM_only boldt_WMM |
| WRN | PCID2 | 0.007 | 0.005 | youn_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06682 has an average edge precision of 0.296 which is ranked 4651 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WRN | HuMAP2_02284 HuMAP2_02836 HuMAP2_03086 HuMAP2_04529 HuMAP2_05224 HuMAP2_05863 HuMAP2_06682 |
| PAXX | HuMAP2_02284 HuMAP2_06682 |
| XRCC6 | HuMAP2_02284 HuMAP2_02836 HuMAP2_03086 HuMAP2_04529 HuMAP2_05224 HuMAP2_05793 HuMAP2_05863 HuMAP2_06682 |
| PCID2 | HuMAP2_06682 |