hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06690
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUPT5H | Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein) | UniProt NCBI |
| SUPT6H | Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein) | UniProt NCBI |
| SUPT4H1 | Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit) | UniProt NCBI |
| IPO7 | Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2860 | 5.02777038712e-06 | 0.5 | SUPT5H SUPT4H1 | DSIF complex (DRB sensitivity-inducing factor complex) |
| CORUM:2861 | 5.02777038712e-06 | 0.5 | SUPT5H SUPT4H1 | DSIF complex (DRB sensitivity-inducing factor complex) |
| REAC:R-HSA-75955 | 4.37783464274e-05 | 0.75 | SUPT5H SUPT6H SUPT4H1 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 4.37783464274e-05 | 0.75 | SUPT5H SUPT6H SUPT4H1 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-674695 | 0.000119121057505 | 0.75 | SUPT5H SUPT6H SUPT4H1 | RNA Polymerase II Pre-transcription Events |
| WP:WP3414 | 0.000729007032317 | 0.5 | SUPT5H SUPT4H1 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| GO:0032786 | 0.00132566605022 | 0.75 | SUPT5H SUPT6H SUPT4H1 | positive regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-167242 | 0.00253927088831 | 0.5 | SUPT5H SUPT4H1 | Abortive elongation of HIV-1 transcript in the absence of Tat |
| GO:0032044 | 0.00270494046827 | 0.5 | SUPT5H SUPT4H1 | DSIF complex |
| REAC:R-HSA-167243 | 0.00497416142364 | 0.5 | SUPT5H SUPT4H1 | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167238 | 0.00497416142364 | 0.5 | SUPT5H SUPT4H1 | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-113418 | 0.00529460041948 | 0.5 | SUPT5H SUPT4H1 | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 0.00529460041948 | 0.5 | SUPT5H SUPT4H1 | Formation of the HIV-1 Early Elongation Complex |
| GO:0032784 | 0.00550256096709 | 0.75 | SUPT5H SUPT6H SUPT4H1 | regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-167287 | 0.00562500866147 | 0.5 | SUPT5H SUPT4H1 | HIV elongation arrest and recovery |
| REAC:R-HSA-167290 | 0.00562500866147 | 0.5 | SUPT5H SUPT4H1 | Pausing and recovery of HIV elongation |
| GO:0008023 | 0.00710332146687 | 0.75 | SUPT5H SUPT6H SUPT4H1 | transcription elongation factor complex |
| REAC:R-HSA-167169 | 0.00947680746611 | 0.5 | SUPT5H SUPT4H1 | HIV Transcription Elongation |
| REAC:R-HSA-167200 | 0.00947680746611 | 0.5 | SUPT5H SUPT4H1 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167246 | 0.00947680746611 | 0.5 | SUPT5H SUPT4H1 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167152 | 0.0103665290697 | 0.5 | SUPT5H SUPT4H1 | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-6796648 | 0.0189130304237 | 0.5 | SUPT5H SUPT4H1 | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-167172 | 0.0248339118539 | 0.5 | SUPT5H SUPT4H1 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.0269852439715 | 0.5 | SUPT5H SUPT4H1 | RNA polymerase II transcribes snRNA genes |
| GO:0006368 | 0.0286174056273 | 0.75 | SUPT5H SUPT6H SUPT4H1 | transcription elongation from RNA polymerase II promoter |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SUPT4H1 | SUPT5H | 0.999 | 0.945 | youn (SUPT5H) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| IPO7 | SUPT5H | 0.954 | 0.861 | youn (SUPT5H) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SUPT6H | SUPT5H | 0.5 | 0.621 | hein_WMM youn (SUPT5H) bioplex_WMM youn_WMM fraction |
| SUPT4H1 | IPO7 | 0.116 | 0.387 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SUPT6H | IPO7 | 0.008 | 0.087 | bioplex_WMM youn_WMM fraction boldt_WMM |
| SUPT4H1 | SUPT6H | 0.003 | 0.013 | hein_WMM bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_06690 has an average edge precision of 0.486 which is ranked 2588 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SUPT5H | HuMAP2_04857 HuMAP2_05384 HuMAP2_05667 HuMAP2_06690 |
| SUPT6H | HuMAP2_04203 HuMAP2_05384 HuMAP2_06690 |
| SUPT4H1 | HuMAP2_00694 HuMAP2_04857 HuMAP2_05384 HuMAP2_05667 HuMAP2_06690 |
| IPO7 | HuMAP2_04857 HuMAP2_06354 HuMAP2_06690 |