hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06693
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PCGF2 | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) | UniProt NCBI |
| CBX8 | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | UniProt NCBI |
| BMI1 | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) | UniProt NCBI |
| PHC1 | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | UniProt NCBI |
| SCMH1 | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | UniProt NCBI |
| CBX4 | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:115 | 2.81642660396e-14 | 0.833333333333 | BMI1 CBX4 PHC1 CBX8 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 4.82788957091e-14 | 0.833333333333 | BMI1 CBX4 PHC1 CBX8 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| REAC:R-HSA-4655427 | 4.83670638587e-13 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | SUMOylation of DNA methylation proteins |
| REAC:R-HSA-3899300 | 1.0583202737e-10 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 1.36803536737e-10 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | SUMOylation of RNA binding proteins |
| GO:0035102 | 1.47519544769e-10 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | PRC1 complex |
| REAC:R-HSA-4551638 | 1.32663300233e-09 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 2.09044250377e-09 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | SUMOylation of DNA damage response and repair proteins |
| CORUM:5513 | 9.01288868683e-09 | 0.5 | BMI1 CBX4 PHC1 | RING1-Polycomb repressive complex |
| GO:0000152 | 4.17250787048e-08 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | nuclear ubiquitin ligase complex |
| GO:0031519 | 6.72200990848e-08 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | PcG protein complex |
| REAC:R-HSA-8939243 | 7.04303391184e-08 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-3108232 | 1.57856898216e-07 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 1.88863196375e-07 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | SUMOylation |
| REAC:R-HSA-8943724 | 4.71230645899e-07 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | Regulation of PTEN gene transcription |
| REAC:R-HSA-2559580 | 1.04049680701e-05 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-6807070 | 1.56538396855e-05 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | PTEN Regulation |
| CORUM:5518 | 2.51655344529e-05 | 0.333333333333 | BMI1 PHC1 | BMI1-HPH1-HPH2 complex |
| REAC:R-HSA-8953750 | 3.54699593753e-05 | 0.5 | PCGF2 PHC1 BMI1 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-2559583 | 5.92853293102e-05 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | Cellular Senescence |
| REAC:R-HSA-8878171 | 0.000109298820952 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 0.000121788581155 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.000227296904657 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | Intracellular signaling by second messengers |
| GO:0000151 | 0.000435366064664 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | ubiquitin ligase complex |
| REAC:R-HSA-2262752 | 0.00129372739211 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | Cellular responses to stress |
| REAC:R-HSA-212436 | 0.00148146469319 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.00253857262834 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | RNA Polymerase II Transcription |
| REAC:R-HSA-8953897 | 0.00265671127538 | 0.666666666667 | BMI1 CBX4 CBX8 PHC1 | Cellular responses to external stimuli |
| REAC:R-HSA-597592 | 0.00391856777133 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | Post-translational protein modification |
| REAC:R-HSA-74160 | 0.00435080618405 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | Gene expression (Transcription) |
| CORUM:929 | 0.00555281871564 | 0.333333333333 | BMI1 CBX8 | CEN complex |
| GO:0070317 | 0.0140408309691 | 0.5 | PCGF2 PHC1 BMI1 | negative regulation of G0 to G1 transition |
| GO:0070316 | 0.0152420239566 | 0.5 | PCGF2 PHC1 BMI1 | regulation of G0 to G1 transition |
| GO:0045023 | 0.0178456165824 | 0.5 | PCGF2 PHC1 BMI1 | G0 to G1 transition |
| GO:0016574 | 0.0222806450818 | 0.5 | PCGF2 PHC1 BMI1 | histone ubiquitination |
| REAC:R-HSA-392499 | 0.0232605972232 | 0.833333333333 | PCGF2 CBX4 PHC1 CBX8 BMI1 | Metabolism of proteins |
| KEGG:04550 | 0.0459708339013 | 0.333333333333 | PCGF2 BMI1 | Signaling pathways regulating pluripotency of stem cells |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PHC1 | BMI1 | 0.997 | 0.93 | bioplex (PHC1) bioplex_WMM |
| CBX8 | PHC1 | 0.986 | 0.901 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM hein (CBX8) |
| SCMH1 | PHC1 | 0.965 | 0.874 | bioplex (PHC1) bioplex_WMM |
| CBX8 | PCGF2 | 0.955 | 0.862 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | SCMH1 | 0.926 | 0.844 | bioplex (PCGF2) bioplex_WMM |
| CBX4 | PHC1 | 0.864 | 0.801 | hein_WMM bioplex (PHC1) bioplex_WMM hein (CBX4) |
| PCGF2 | PHC1 | 0.706 | 0.727 | bioplex (PCGF2,PHC1) bioplex_WMM |
| PCGF2 | CBX4 | 0.369 | 0.544 | bioplex (PCGF2) bioplex_WMM |
| CBX8 | CBX4 | 0.073 | 0.354 | hein_WMM bioplex_WMM hein (CBX4,CBX8) |
| CBX8 | SCMH1 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| SCMH1 | CBX4 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| CBX8 | BMI1 | 0.008 | 0.088 | bioplex_WMM WMM_only |
| SCMH1 | BMI1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PCGF2 | BMI1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CBX4 | BMI1 | 0.008 | 0.066 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06693 has an average edge precision of 0.49 which is ranked 2550 out of all 6965 complexes.
Related Complexes