hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06702
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLGAP5 | Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP) | UniProt NCBI |
| TUBB4A | Tubulin beta-4A chain (Tubulin 5 beta) (Tubulin beta-4 chain) | UniProt NCBI |
| TUBB3 | Tubulin beta-3 chain (Tubulin beta-4 chain) (Tubulin beta-III) | UniProt NCBI |
| EML6 | Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like) | UniProt NCBI |
| TUBB2B | Tubulin beta-2B chain | UniProt NCBI |
| TUBB6 | Tubulin beta-6 chain (Tubulin beta class V) | UniProt NCBI |
| CAPS | Calcyphosin (Calcyphosine) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-190840 | 6.78225759637e-09 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 8.7186390663e-09 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Transport of connexons to the plasma membrane |
| REAC:R-HSA-389977 | 1.70443817949e-08 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-190861 | 2.52095754391e-08 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Gap junction assembly |
| REAC:R-HSA-9619483 | 3.02466099648e-08 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 3.02466099648e-08 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-389957 | 4.99314041853e-08 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-5626467 | 5.82439048525e-08 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 8.94631183986e-08 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-190828 | 1.31795103421e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Gap junction trafficking |
| REAC:R-HSA-157858 | 1.48776903705e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Gap junction trafficking and regulation |
| REAC:R-HSA-8955332 | 1.87601191777e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 2.09638069879e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Assembly and cell surface presentation of NMDA receptors |
| WP:WP2272 | 2.44014245861e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-437239 | 4.22674731879e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Recycling pathway of L1 |
| WP:WP2359 | 6.48142755071e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-6811436 | 6.52796408062e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-5620924 | 7.08239116161e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Intraflagellar transport |
| REAC:R-HSA-3371497 | 7.67135087323e-07 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| REAC:R-HSA-983189 | 1.11840907036e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Kinesins |
| KEGG:04540 | 1.70476329132e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Gap junction |
| REAC:R-HSA-1445148 | 2.30170723977e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-438064 | 3.07375784275e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Post NMDA receptor activation events |
| REAC:R-HSA-8852276 | 3.62140081949e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-442755 | 5.4392781937e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-390466 | 7.19610867202e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Chaperonin-mediated protein folding |
| REAC:R-HSA-380320 | 7.19610867202e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-391251 | 9.34645756121e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Protein folding |
| REAC:R-HSA-6811434 | 9.34645756121e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 9.74687731254e-06 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | COPI-mediated anterograde transport |
| KEGG:04145 | 1.15953300137e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Phagosome |
| REAC:R-HSA-373760 | 1.68093949516e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | L1CAM interactions |
| REAC:R-HSA-5610787 | 1.68093949516e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Hedgehog 'off' state |
| REAC:R-HSA-2132295 | 2.00804467107e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 2.30223008303e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 3.17830201784e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Golgi-to-ER retrograde transport |
| KEGG:05130 | 3.43977364135e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-5663220 | 3.48399314081e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | RHO GTPases Activate Formins |
| REAC:R-HSA-5358351 | 4.53370395775e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Signaling by Hedgehog |
| REAC:R-HSA-199977 | 4.79587526056e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-983231 | 7.13974352246e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-948021 | 9.11840957805e-05 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-112314 | 0.00010486652338 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2467813 | 0.000125424876484 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Separation of Sister Chromatids |
| REAC:R-HSA-69275 | 0.000145757367149 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | G2/M Transition |
| REAC:R-HSA-5617833 | 0.0001488509542 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Cilium Assembly |
| REAC:R-HSA-68877 | 0.0001488509542 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.0001488509542 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000151993265715 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 0.000151993265715 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Mitotic G2-G2/M phases |
| REAC:R-HSA-6811442 | 0.00016845334948 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-112315 | 0.000296731739946 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Transmission across Chemical Synapses |
| HP:0001491 | 0.000346286800202 | 0.285714285714 | TUBB2B TUBB3 | Congenital fibrosis of extraocular muscles |
| REAC:R-HSA-1852241 | 0.000674763624421 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Organelle biogenesis and maintenance |
| REAC:R-HSA-446203 | 0.000734322285617 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Asparagine N-linked glycosylation |
| REAC:R-HSA-195258 | 0.00101240038307 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | RHO GTPase Effectors |
| REAC:R-HSA-112316 | 0.00149643184588 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Neuronal System |
| HP:0008049 | 0.00173027154874 | 0.285714285714 | TUBB2B TUBB3 | Abnormality of the extraocular muscles |
| GO:0005200 | 0.00215163649293 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | structural constituent of cytoskeleton |
| HP:0003828 | 0.00215959234857 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Variable expressivity |
| REAC:R-HSA-68886 | 0.00222625241558 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | M Phase |
| REAC:R-HSA-2262752 | 0.00301271618311 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Cellular responses to stress |
| REAC:R-HSA-194315 | 0.00374244313656 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Signaling by Rho GTPases |
| REAC:R-HSA-8953897 | 0.00615930257424 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Cellular responses to external stimuli |
| HP:0003812 | 0.00706561882508 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Phenotypic variability |
| HP:0012823 | 0.00714273602289 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Clinical modifier |
| REAC:R-HSA-422475 | 0.00749530493622 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Axon guidance |
| REAC:R-HSA-69278 | 0.0076688970217 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Cell Cycle, Mitotic |
| REAC:R-HSA-109582 | 0.00890318946488 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Hemostasis |
| REAC:R-HSA-199991 | 0.0122104245536 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0150589916515 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Vesicle-mediated transport |
| REAC:R-HSA-1640170 | 0.0155446721983 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Cell Cycle |
| REAC:R-HSA-1280218 | 0.0187049526139 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | Adaptive Immune System |
| GO:0005525 | 0.0285804850445 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | GTP binding |
| HP:0001328 | 0.0285882991569 | 0.428571428571 | TUBB4A TUBB2B TUBB3 | Specific learning disability |
| GO:0032549 | 0.0383291828166 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | ribonucleoside binding |
| GO:0032550 | 0.0383291828166 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | purine ribonucleoside binding |
| GO:0001883 | 0.0391698656597 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | purine nucleoside binding |
| GO:0001882 | 0.041774596669 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | nucleoside binding |
| GO:0032561 | 0.0483535565353 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | guanyl ribonucleotide binding |
| GO:0019001 | 0.0493528907409 | 0.571428571429 | TUBB6 TUBB4A TUBB2B TUBB3 | guanyl nucleotide binding |
| CORUM:7241 | 0.0499886427319 | 0.142857142857 | TUBB3 | SNCA-TUBB3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBB3 | DLGAP5 | 0.89 | 0.818 | bioplex (TUBB3) bioplex_WMM youn_WMM gupta_WMM |
| TUBB3 | EML6 | 0.203 | 0.453 | bioplex (TUBB3) bioplex_WMM |
| TUBB6 | TUBB2B | 0.107 | 0.373 | bioplex (TUBB2B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB6 | TUBB3 | 0.099 | 0.358 | hein_WMM bioplex (TUBB3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB2B | TUBB3 | 0.099 | 0.358 | bioplex (TUBB2B,TUBB3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB2B | CAPS | 0.075 | 0.357 | bioplex (TUBB2B) bioplex_WMM |
| TUBB4A | TUBB3 | 0.074 | 0.357 | bioplex (TUBB3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB4A | TUBB2B | 0.048 | 0.295 | bioplex (TUBB2B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TUBB2B | EML6 | 0.047 | 0.294 | bioplex (TUBB2B) bioplex_WMM boldt_WMM |
| TUBB6 | TUBB4A | 0.036 | 0.263 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| EML6 | CAPS | 0.009 | 0.104 | bioplex_WMM WMM_only |
| TUBB6 | EML6 | 0.009 | 0.098 | bioplex_WMM WMM_only boldt_WMM |
| EML6 | DLGAP5 | 0.008 | 0.048 | bioplex_WMM WMM_only |
| TUBB6 | CAPS | 0.008 | 0.031 | bioplex_WMM WMM_only |
| TUBB6 | DLGAP5 | 0.007 | 0.008 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TUBB4A | EML6 | 0.007 | 0.008 | bioplex_WMM WMM_only boldt_WMM |
| TUBB4A | DLGAP5 | 0.007 | 0.016 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TUBB2B | DLGAP5 | 0.007 | 0.01 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TUBB3 | CAPS | 0.007 | 0.004 | bioplex_WMM WMM_only |
| TUBB4A | CAPS | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06702 has an average edge precision of 0.213 which is ranked 5981 out of all 6965 complexes.
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