hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06706

Confidence: Medium High

Genename	Protein Name	Links
LIMA1	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)	UniProt NCBI
DBN1	Drebrin (Developmentally-regulated brain protein)	UniProt NCBI
ACTG1	Actin, cytoplasmic 2 (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]	UniProt NCBI
MISP	Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)	UniProt NCBI
MYO1D	Unconventional myosin-Id	UniProt NCBI
MYO1E	Unconventional myosin-Ie (Myosin-Ic) (Unconventional myosin 1E)	UniProt NCBI
MYO6	Unconventional myosin-VI (Unconventional myosin-6)	UniProt NCBI
TMOD2	Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)	UniProt NCBI
GSN	Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin)	UniProt NCBI
MYO1C	Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)	UniProt NCBI
MYH9	Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)	UniProt NCBI
CALML3	Calmodulin-like protein 3 (CaM-like protein) (CLP) (Calmodulin-related protein NB-1)	UniProt NCBI
SVIL	Supervillin (Archvillin) (p205/p250)	UniProt NCBI
TMOD3	Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)	UniProt NCBI
NEXN	Nexilin (F-actin-binding protein) (Nelin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0015629	1.01048257912e-14	0.866666666667	MYO1C MYO1D SVIL MYO6 TMOD3 MYO1E ACTG1 TMOD2 MYH9 GSN DBN1 MISP LIMA1	actin cytoskeleton
GO:0051015	1.2009115321e-10	0.6	MYO1D MYO6 MYO1E MYH9 LIMA1 DBN1 NEXN MISP SVIL	actin filament binding
GO:0003779	3.58826535422e-10	0.666666666667	MYO1D SVIL MYO6 MYO1E MYH9 GSN DBN1 NEXN MISP LIMA1	actin binding
GO:0008092	2.7293690146e-09	0.8	MYO1D SVIL MYO6 MYO1E TMOD3 TMOD2 MYH9 GSN DBN1 NEXN MISP LIMA1	cytoskeletal protein binding
GO:0044430	2.26920313002e-08	0.866666666667	MYO1C MYO1D SVIL MYO6 TMOD3 MYO1E ACTG1 TMOD2 MYH9 GSN DBN1 MISP LIMA1	cytoskeletal part
GO:0005856	3.61156894767e-07	0.866666666667	MYO1C MYO1D SVIL MYO6 TMOD3 MYO1E ACTG1 TMOD2 MYH9 GSN DBN1 MISP LIMA1	cytoskeleton
KEGG:05130	6.33092997814e-07	0.4	MYO1C MYO1D MYO6 MYO1E ACTG1 MYH9	Pathogenic Escherichia coli infection
GO:0005912	4.64673851083e-06	0.6	SVIL TMOD3 MYO1E ACTG1 MYH9 GSN NEXN MISP LIMA1	adherens junction
GO:0070161	5.74585599593e-06	0.6	SVIL TMOD3 MYO1E ACTG1 MYH9 GSN NEXN MISP LIMA1	anchoring junction
GO:0016459	5.74768938016e-06	0.333333333333	MYH9 MYO1C MYO6 MYO1D MYO1E	myosin complex
GO:0099512	1.51984860019e-05	0.6	SVIL TMOD2 MYO6 TMOD3 ACTG1 MYO1C DBN1 MISP NEXN	supramolecular fiber
GO:0099081	1.68239335478e-05	0.6	SVIL TMOD2 MYO6 TMOD3 ACTG1 MYO1C DBN1 MISP NEXN	supramolecular polymer
GO:0099080	1.71092789683e-05	0.6	SVIL TMOD2 MYO6 TMOD3 ACTG1 MYO1C DBN1 MISP NEXN	supramolecular complex
GO:0000146	0.000127930833179	0.266666666667	MYH9 MYO6 MYO1D MYO1E	microfilament motor activity
GO:0030054	0.000175029722217	0.6	SVIL TMOD3 MYO1E ACTG1 MYH9 GSN NEXN MISP LIMA1	cell junction
GO:0044877	0.000515410069204	0.6	MYO1D MYO6 MYO1E MYH9 LIMA1 DBN1 NEXN MISP SVIL	protein-containing complex binding
GO:0005925	0.00110313352839	0.466666666667	SVIL ACTG1 MYH9 GSN NEXN MISP LIMA1	focal adhesion
GO:0043232	0.00111886786176	0.933333333333	MYO1C MYO1D SVIL MYO6 TMOD3 MYO1E ACTG1 TMOD2 MYH9 GSN DBN1 NEXN MISP LIMA1	intracellular non-membrane-bounded organelle
GO:0043228	0.00112754450935	0.933333333333	MYO1C MYO1D SVIL MYO6 TMOD3 MYO1E ACTG1 TMOD2 MYH9 GSN DBN1 NEXN MISP LIMA1	non-membrane-bounded organelle
GO:0005924	0.00114679483585	0.466666666667	SVIL ACTG1 MYH9 GSN NEXN MISP LIMA1	cell-substrate adherens junction
GO:0030029	0.0011586489663	0.533333333333	MYO6 MYO1E TMOD2 MYH9 LIMA1 DBN1 TMOD3 GSN	actin filament-based process
GO:0030055	0.00126242343638	0.466666666667	SVIL ACTG1 MYH9 GSN NEXN MISP LIMA1	cell-substrate junction
CORUM:5604	0.00130772247752	0.133333333333	MYH9 MYO1E	Emerin complex 1
GO:0005884	0.00150565768226	0.333333333333	DBN1 MYO6 ACTG1 MYO1C MISP	actin filament
REAC:R-HSA-2029482	0.00698180724433	0.2	MYH9 ACTG1 MYO1C	Regulation of actin dynamics for phagocytic cup formation
REAC:R-HSA-1445148	0.0107047299719	0.2	MYH9 ACTG1 MYO1C	Translocation of SLC2A4 (GLUT4) to the plasma membrane
REAC:R-HSA-190873	0.0166993211532	0.133333333333	MYO6 ACTG1	Gap junction degradation
REAC:R-HSA-2029480	0.0174223240929	0.2	MYH9 ACTG1 MYO1C	Fcgamma receptor (FCGR) dependent phagocytosis
GO:0030864	0.0277015394675	0.266666666667	MYH9 DBN1 MISP GSN	cortical actin cytoskeleton
KEGG:04810	0.0423562150582	0.2	MYH9 ACTG1 GSN	Regulation of actin cytoskeleton
GO:1900756	0.0473364581948	0.133333333333	MYH9 GSN	protein processing in phagocytic vesicle
GO:1903921	0.0473364581948	0.133333333333	MYH9 GSN	regulation of protein processing in phagocytic vesicle
GO:1903923	0.0473364581948	0.133333333333	MYH9 GSN	positive regulation of protein processing in phagocytic vesicle

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SVIL	TMOD3	0.979	0.895	hein_WMM bioplex (TMOD3) bioplex_WMM youn_WMM hein (TMOD3) gupta_WMM
DBN1	LIMA1	0.831	0.778	hein_WMM bioplex_WMM youn_WMM hein (DBN1,LIMA1) gupta_WMM treiber_WMM
TMOD3	LIMA1	0.823	0.774	hein_WMM bioplex (TMOD3) bioplex_WMM youn_WMM hein (LIMA1) gupta_WMM
DBN1	GSN	0.641	0.688	hein_WMM bioplex (DBN1) bioplex_WMM hein (DBN1) boldt_WMM treiber_WMM
NEXN	LIMA1	0.422	0.573	hein_WMM bioplex (NEXN) bioplex_WMM hein (LIMA1)
TMOD3	NEXN	0.407	0.566	hein_WMM bioplex (NEXN) bioplex_WMM hein (TMOD3)
TMOD3	MYH9	0.349	0.536	hein_WMM bioplex (MYH9,TMOD3) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM boldt_WMM treiber_WMM
MYO1E	MYO1C	0.342	0.531	hein_WMM bioplex_WMM boldt youn_WMM hein (MYO1C) boldt_WMM treiber_WMM
ACTG1	MYH9	0.322	0.512	hein_WMM hein (MYH9) gupta_WMM boldt_WMM
LIMA1	ACTG1	0.27	0.483	hein_WMM hein (LIMA1) gupta_WMM
DBN1	MYO6	0.264	0.481	hein_WMM bioplex (DBN1,MYO6) bioplex_WMM youn_WMM hein (DBN1) gupta_WMM treiber_WMM
TMOD3	GSN	0.189	0.441	hein_WMM bioplex (TMOD3) bioplex_WMM hein (TMOD3) fraction boldt_WMM
MYO1C	ACTG1	0.17	0.427	hein_WMM hein (MYO1C) boldt_WMM
DBN1	ACTG1	0.152	0.409	hein_WMM hein (DBN1) gupta_WMM boldt_WMM
DBN1	CALML3	0.15	0.41	hein_WMM bioplex_WMM hein (CALML3)
ACTG1	CALML3	0.146	0.409	hein_WMM hein (CALML3) boldt_WMM
LIMA1	CALML3	0.141	0.405	hein_WMM bioplex_WMM hein (CALML3)
TMOD3	ACTG1	0.129	0.4	hein_WMM hein (TMOD3) gupta_WMM boldt_WMM
TMOD3	MYO1C	0.124	0.397	hein_WMM bioplex (TMOD3) bioplex_WMM youn_WMM hein (MYO1C)
MYO1C	CALML3	0.112	0.38	hein_WMM bioplex_WMM hein (CALML3)
MISP	CALML3	0.107	0.372	hein_WMM hein (CALML3)
NEXN	CALML3	0.1	0.36	hein_WMM hein (CALML3)
SVIL	CALML3	0.089	0.352	hein_WMM hein (CALML3)
MYO1C	LIMA1	0.085	0.349	hein_WMM bioplex_WMM youn_WMM hein (LIMA1,MYO1C) treiber_WMM
TMOD3	MYO1E	0.068	0.348	hein_WMM bioplex (TMOD3) bioplex_WMM youn_WMM hein (TMOD3) gupta_WMM
MYO1C	DBN1	0.067	0.35	hein_WMM bioplex (DBN1) bioplex_WMM youn_WMM hein (DBN1,MYO1C) treiber_WMM
MYO1C	MYO1D	0.066	0.35	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
MISP	LIMA1	0.065	0.347	hein_WMM hein (LIMA1) treiber_WMM
TMOD3	MYO6	0.064	0.348	hein_WMM bioplex (MYO6,TMOD3) bioplex_WMM youn_WMM hein (TMOD3) gupta_WMM fraction
NEXN	MYH9	0.059	0.328	hein_WMM bioplex (NEXN) bioplex_WMM hein (MYH9)
MISP	MYH9	0.058	0.323	hein_WMM hein (MYH9) treiber_WMM
GSN	TMOD2	0.057	0.321	bioplex (TMOD2) bioplex_WMM
MISP	DBN1	0.057	0.321	hein_WMM hein (DBN1) treiber_WMM
LIMA1	MYH9	0.056	0.312	hein_WMM bioplex_WMM youn_WMM hein (MYH9) gupta_WMM treiber_WMM
TMOD3	CALML3	0.055	0.306	hein_WMM bioplex_WMM hein (CALML3)
NEXN	DBN1	0.053	0.301	hein_WMM bioplex (NEXN) hein (DBN1)
MYO1E	CALML3	0.047	0.292	hein_WMM bioplex_WMM hein (CALML3)
MYO1C	MISP	0.045	0.293	hein_WMM bioplex (MISP) hein (MYO1C) treiber_WMM
MYO1C	GSN	0.043	0.272	hein_WMM bioplex_WMM hein (MYO1C) treiber_WMM
MYO1C	MYO6	0.043	0.269	hein_WMM bioplex (MYO6) bioplex_WMM boldt youn_WMM hein (MYO1C) boldt_WMM treiber_WMM
MYO1C	MYH9	0.043	0.269	hein_WMM bioplex_WMM boldt youn_WMM hein (MYH9,MYO1C) boldt_WMM treiber_WMM
SVIL	LIMA1	0.042	0.268	hein_WMM bioplex_WMM youn_WMM hein (LIMA1) gupta_WMM
LIMA1	GSN	0.04	0.268	hein_WMM bioplex_WMM hein (LIMA1) treiber_WMM
LIMA1	MYO6	0.039	0.266	hein_WMM bioplex (MYO6) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
MYH9	CALML3	0.039	0.265	hein_WMM bioplex_WMM boldt hein (MYH9) boldt_WMM treiber_WMM
SVIL	DBN1	0.033	0.247	hein_WMM youn_WMM hein (DBN1) gupta_WMM
NEXN	GSN	0.024	0.214	hein_WMM bioplex (NEXN) bioplex_WMM
MYO1E	DBN1	0.024	0.213	hein_WMM bioplex (DBN1) bioplex_WMM youn_WMM hein (DBN1) gupta_WMM treiber_WMM
MYH9	GSN	0.024	0.214	hein_WMM bioplex_WMM hein (MYH9) boldt_WMM treiber_WMM
SVIL	MYH9	0.021	0.187	hein_WMM bioplex_WMM youn_WMM hein (MYH9) gupta_WMM treiber_WMM
SVIL	MYO1C	0.019	0.186	hein_WMM bioplex_WMM youn_WMM hein (MYO1C) boldt_WMM
TMOD3	TMOD2	0.018	0.177	bioplex (TMOD2) bioplex_WMM gupta_WMM
MYO1E	MYH9	0.017	0.174	hein_WMM bioplex (MYH9) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM fraction treiber_WMM
MYO6	GSN	0.013	0.148	hein_WMM bioplex (MYO6) bioplex_WMM treiber_WMM
MYO1E	NEXN	0.013	0.154	hein_WMM bioplex (NEXN) bioplex_WMM
MYO6	MYH9	0.01	0.117	hein_WMM bioplex (MYH9,MYO6) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM treiber_WMM
MYO1E	MYO6	0.009	0.098	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
NEXN	MYO1D	0.008	0.021	bioplex (NEXN) bioplex_WMM
SVIL	MYO1D	0.007	0.001	youn_WMM gupta_WMM WMM_only boldt_WMM
MYO6	TMOD2	0.007	0.003	bioplex (MYO6,TMOD2) bioplex_WMM gupta_WMM
ACTG1	MYO1D	0.007	0.001	gupta_WMM WMM_only boldt_WMM
CALML3	TMOD2	0.007	0.002	bioplex_WMM WMM_only
ACTG1	TMOD2	0.007	0.002	gupta_WMM WMM_only
MYO1E	LIMA1	0.007	0.002	hein_WMM bioplex_WMM youn_WMM hein (LIMA1) gupta_WMM treiber_WMM
MYO6	CALML3	0.007	0.006	hein_WMM bioplex_WMM hein (CALML3)
MYO6	MYO1D	0.006	0.005	bioplex (MYO1D,MYO6) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
SVIL	NEXN	0.006	0.006	hein_WMM WMM_only
NEXN	MISP	0.006	0.008	hein_WMM WMM_only
MYO1E	MYO1D	0.006	0.007	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
NEXN	MYO6	0.006	0.008	hein_WMM bioplex (NEXN)
MYO1E	ACTG1	0.006	0.009	hein_WMM WMM_only
MYO1D	GSN	0.006	0.009	bioplex_WMM WMM_only treiber_WMM
ACTG1	GSN	0.006	0.009	hein_WMM boldt boldt_WMM
NEXN	ACTG1	0.006	0.008	hein_WMM WMM_only
MYO1E	MISP	0.005	0.014	hein_WMM WMM_only treiber_WMM
MYH9	MYO1D	0.005	0.01	bioplex (MYO1D) bioplex_WMM youn_WMM gupta_WMM boldt_WMM treiber_WMM
DBN1	MYO1D	0.005	0.01	bioplex (DBN1) bioplex_WMM youn_WMM gupta_WMM
SVIL	ACTG1	0.005	0.012	hein_WMM gupta_WMM WMM_only
MISP	MYO6	0.005	0.007	hein_WMM bioplex (MISP) treiber_WMM
CALML3	GSN	0.005	0.01	hein_WMM bioplex_WMM boldt boldt_WMM
SVIL	MYO1E	0.005	0.016	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
LIMA1	MYO1D	0.005	0.008	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
TMOD3	MYO1D	0.005	0.012	bioplex (TMOD3) bioplex_WMM gupta_WMM
LIMA1	TMOD2	0.004	0.013	bioplex (TMOD2) bioplex_WMM
NEXN	TMOD2	0.004	0.012	bioplex (NEXN) bioplex_WMM
MYO1D	TMOD2	0.004	0.012	bioplex (TMOD2) bioplex_WMM gupta_WMM
ACTG1	MYO6	0.004	0.012	hein_WMM gupta_WMM WMM_only
MISP	ACTG1	0.004	0.009	hein_WMM WMM_only
MYO1E	GSN	0.004	0.008	hein_WMM bioplex_WMM WMM_only treiber_WMM
MYO1C	TMOD2	0.004	0.013	bioplex (TMOD2) bioplex_WMM
MISP	MYO1D	0.004	0.01	bioplex (MISP)
SVIL	MISP	0.004	0.016	hein_WMM WMM_only
TMOD3	MISP	0.004	0.014	hein_WMM WMM_only
SVIL	GSN	0.004	0.011	hein_WMM bioplex_WMM WMM_only
SVIL	MYO6	0.004	0.012	hein_WMM youn_WMM gupta_WMM WMM_only
MISP	GSN	0.003	0.011	hein_WMM WMM_only treiber_WMM
TMOD3	DBN1	0.003	0.012	hein_WMM bioplex (DBN1,TMOD3) bioplex_WMM youn_WMM hein (DBN1,TMOD3) gupta_WMM fraction boldt_WMM
DBN1	MYH9	0.0	0.013	hein_WMM bioplex (DBN1,MYH9) bioplex_WMM youn_WMM hein (MYH9) gupta_WMM fraction boldt_WMM treiber_WMM
MYO1E	TMOD2	0.0	0.01	bioplex_WMM fraction
MYO1C	NEXN	0.0	0.01	hein_WMM bioplex (NEXN) bioplex_WMM hein (MYO1C)
DBN1	TMOD2	0.0	0.013	bioplex (DBN1) bioplex_WMM gupta_WMM fraction
MYH9	TMOD2	0.0	0.0	bioplex (TMOD2) bioplex_WMM gupta_WMM

Images

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Complex HuMAP2_06706 has an average edge precision of 0.205 which is ranked 6117 out of all 6965 complexes.

Related Complexes

Genename	Complexes
LIMA1	HuMAP2_01907 HuMAP2_02160 HuMAP2_02789 HuMAP2_04716 HuMAP2_06706
DBN1	HuMAP2_01907 HuMAP2_02160 HuMAP2_04716 HuMAP2_05657 HuMAP2_06706
ACTG1	HuMAP2_02160 HuMAP2_03895 HuMAP2_06706 HuMAP2_06976
MISP	HuMAP2_00566 HuMAP2_02160 HuMAP2_05297 HuMAP2_05462 HuMAP2_05657 HuMAP2_06706
MYO1D	HuMAP2_02877 HuMAP2_05019 HuMAP2_06706
MYO1E	HuMAP2_00433 HuMAP2_01461 HuMAP2_01930 HuMAP2_06706
MYO6	HuMAP2_02160 HuMAP2_02314 HuMAP2_05657 HuMAP2_06020 HuMAP2_06706 HuMAP2_06848
TMOD2	HuMAP2_06038 HuMAP2_06621 HuMAP2_06706
GSN	HuMAP2_04716 HuMAP2_05657 HuMAP2_06038 HuMAP2_06706
MYO1C	HuMAP2_00433 HuMAP2_01461 HuMAP2_01930 HuMAP2_02160 HuMAP2_06706
MYH9	HuMAP2_02160 HuMAP2_02178 HuMAP2_03239 HuMAP2_03956 HuMAP2_06706
CALML3	HuMAP2_02160 HuMAP2_02789 HuMAP2_05394 HuMAP2_06706
SVIL	HuMAP2_00057 HuMAP2_00088 HuMAP2_02160 HuMAP2_02789 HuMAP2_06706
TMOD3	HuMAP2_00057 HuMAP2_00088 HuMAP2_02160 HuMAP2_02314 HuMAP2_02789 HuMAP2_06706
NEXN	HuMAP2_00523 HuMAP2_02160 HuMAP2_02789 HuMAP2_06706

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06706