hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06707
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TLE5 | TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator) | UniProt NCBI |
| TLE4 | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | UniProt NCBI |
| TLE2 | Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2) | UniProt NCBI |
| TLE1 | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4641265 | 4.48914604804e-11 | 1.0 | TLE4 TLE2 TLE5 TLE1 | Repression of WNT target genes |
| REAC:R-HSA-195253 | 1.58621935087e-07 | 1.0 | TLE4 TLE2 TLE5 TLE1 | Degradation of beta-catenin by the destruction complex |
| CORUM:3124 | 5.02777038712e-06 | 0.5 | TLE2 TLE1 | TLE1-TLE2 complex |
| REAC:R-HSA-3769402 | 1.23194951195e-05 | 0.75 | TLE4 TLE2 TLE1 | Deactivation of the beta-catenin transactivating complex |
| GO:0070491 | 1.27309456693e-05 | 1.0 | TLE4 TLE2 TLE5 TLE1 | repressing transcription factor binding |
| REAC:R-HSA-2122947 | 1.66324766473e-05 | 0.75 | TLE4 TLE2 TLE1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-195721 | 3.42260325769e-05 | 1.0 | TLE4 TLE2 TLE5 TLE1 | Signaling by WNT |
| REAC:R-HSA-1980143 | 5.60927864057e-05 | 0.75 | TLE4 TLE2 TLE1 | Signaling by NOTCH1 |
| REAC:R-HSA-201722 | 0.000152699585722 | 0.75 | TLE4 TLE2 TLE1 | Formation of the beta-catenin:TCF transactivating complex |
| GO:0090090 | 0.000396049862747 | 1.0 | TLE4 TLE2 TLE5 TLE1 | negative regulation of canonical Wnt signaling pathway |
| GO:0030178 | 0.000657808747052 | 1.0 | TLE4 TLE2 TLE5 TLE1 | negative regulation of Wnt signaling pathway |
| GO:1904837 | 0.00147288799354 | 0.75 | TLE4 TLE2 TLE1 | beta-catenin-TCF complex assembly |
| GO:0003714 | 0.00148476668027 | 1.0 | TLE4 TLE2 TLE5 TLE1 | transcription corepressor activity |
| GO:0060828 | 0.00215171705405 | 1.0 | TLE4 TLE2 TLE5 TLE1 | regulation of canonical Wnt signaling pathway |
| REAC:R-HSA-157118 | 0.00233820035489 | 0.75 | TLE4 TLE2 TLE1 | Signaling by NOTCH |
| REAC:R-HSA-201681 | 0.00240260362929 | 0.75 | TLE4 TLE2 TLE1 | TCF dependent signaling in response to WNT |
| GO:0060070 | 0.0038760338754 | 1.0 | TLE4 TLE2 TLE5 TLE1 | canonical Wnt signaling pathway |
| GO:0005667 | 0.00406662724791 | 1.0 | TLE4 TLE2 TLE5 TLE1 | transcription factor complex |
| GO:0030111 | 0.00544194080262 | 1.0 | TLE4 TLE2 TLE5 TLE1 | regulation of Wnt signaling pathway |
| GO:0140297 | 0.00656596129082 | 1.0 | TLE4 TLE2 TLE5 TLE1 | DNA-binding transcription factor binding |
| GO:0016055 | 0.0175518684514 | 1.0 | TLE4 TLE2 TLE5 TLE1 | Wnt signaling pathway |
| GO:0198738 | 0.0183394964461 | 1.0 | TLE4 TLE2 TLE5 TLE1 | cell-cell signaling by wnt |
| GO:1905114 | 0.0243708967076 | 1.0 | TLE4 TLE2 TLE5 TLE1 | cell surface receptor signaling pathway involved in cell-cell signaling |
| CORUM:3123 | 0.0249595281251 | 0.25 | TLE2 | TLE2 homodimer complex |
| CORUM:3125 | 0.0249595281251 | 0.25 | TLE1 | TLE1 homodimer complex |
| CORUM:3127 | 0.0249595281251 | 0.25 | TLE1 | TLE-Histone H3 complex |
| CORUM:3121 | 0.0499140284799 | 0.25 | TLE4 | OCT2-TLE4 complex |
| CORUM:3164 | 0.0499140284799 | 0.25 | TLE1 | HESX1-TLE1 complex |
| CORUM:3150 | 0.0499140284799 | 0.25 | TLE1 | NK-3-Groucho complex |
| CORUM:6769 | 0.0499140284799 | 0.25 | TLE1 | TBX20-TLE1 repressor complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TLE4 | TLE2 | 1.0 | 0.949 | bioplex (TLE4) bioplex_WMM |
| TLE5 | TLE4 | 0.994 | 0.923 | bioplex (TLE4) bioplex_WMM youn_WMM |
| TLE1 | TLE4 | 0.98 | 0.896 | bioplex (TLE4) bioplex_WMM youn_WMM |
| TLE1 | TLE2 | 0.017 | 0.175 | bioplex_WMM WMM_only |
| TLE1 | TLE5 | 0.012 | 0.146 | bioplex_WMM youn_WMM WMM_only |
| TLE5 | TLE2 | 0.011 | 0.14 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06707 has an average edge precision of 0.538 which is ranked 2287 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TLE5 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| TLE4 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| TLE2 | HuMAP2_04314 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| TLE1 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |