hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06718
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| STAMBPL1 | AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) | UniProt NCBI |
| HIP1R | Huntingtin-interacting protein 1-related protein (HIP1-related protein) (Huntingtin-interacting protein 12) (HIP-12) | UniProt NCBI |
| HIP1 | Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) | UniProt NCBI |
| PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | UniProt NCBI |
| GAK | Cyclin-G-associated kinase (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856828 | 3.99365490063e-06 | 0.8 | PIK3C2A GAK HIP1 HIP1R | Clathrin-mediated endocytosis |
| REAC:R-HSA-432722 | 6.70990066737e-05 | 0.6 | GAK HIP1R PIK3C2A | Golgi Associated Vesicle Biogenesis |
| REAC:R-HSA-199992 | 0.000161043167075 | 0.6 | GAK HIP1R PIK3C2A | trans-Golgi Network Vesicle Budding |
| GO:0048268 | 0.000199619769136 | 0.6 | PIK3C2A HIP1 HIP1R | clathrin coat assembly |
| REAC:R-HSA-199991 | 0.00166286547268 | 0.8 | PIK3C2A GAK HIP1 HIP1R | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0020580612036 | 0.8 | PIK3C2A GAK HIP1 HIP1R | Vesicle-mediated transport |
| GO:2000588 | 0.00450823411379 | 0.4 | HIP1 HIP1R | positive regulation of platelet-derived growth factor receptor-beta signaling pathway |
| GO:0048008 | 0.0049400991777 | 0.6 | PIK3C2A HIP1 HIP1R | platelet-derived growth factor receptor signaling pathway |
| GO:0030276 | 0.00964423896068 | 0.6 | GAK HIP1 HIP1R | clathrin binding |
| GO:0010641 | 0.0270421395626 | 0.4 | HIP1 HIP1R | positive regulation of platelet-derived growth factor receptor signaling pathway |
| GO:0032051 | 0.0450641792523 | 0.4 | HIP1 HIP1R | clathrin light chain binding |
| GO:2000586 | 0.0450641792523 | 0.4 | HIP1 HIP1R | regulation of platelet-derived growth factor receptor-beta signaling pathway |
| CORUM:1130 | 0.0499494897235 | 0.2 | HIP1R | Hip1R-cortactin complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIK3C2A | STAMBPL1 | 0.33 | 0.52 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| GAK | STAMBPL1 | 0.274 | 0.486 | hein_WMM bioplex (STAMBPL1) bioplex_WMM hein (GAK) |
| HIP1R | STAMBPL1 | 0.047 | 0.294 | hein_WMM bioplex (HIP1R,STAMBPL1) bioplex_WMM |
| HIP1 | HIP1R | 0.041 | 0.27 | hein_WMM bioplex (HIP1R) bioplex_WMM |
| GAK | HIP1R | 0.024 | 0.214 | hein_WMM bioplex (HIP1R) bioplex_WMM youn_WMM hein (GAK) |
| GAK | PIK3C2A | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM hein (GAK) gupta_WMM |
| HIP1 | STAMBPL1 | 0.01 | 0.102 | hein_WMM bioplex_WMM WMM_only |
| HIP1 | PIK3C2A | 0.008 | 0.061 | hein_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| HIP1R | PIK3C2A | 0.008 | 0.032 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GAK | HIP1 | 0.004 | 0.013 | hein_WMM bioplex_WMM youn_WMM hein (GAK) |
Images
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Complex HuMAP2_06718 has an average edge precision of 0.213 which is ranked 5972 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| STAMBPL1 | HuMAP2_02565 HuMAP2_02883 HuMAP2_04785 HuMAP2_06718 |
| HIP1R | HuMAP2_00186 HuMAP2_02918 HuMAP2_04182 HuMAP2_06718 |
| HIP1 | HuMAP2_00186 HuMAP2_01406 HuMAP2_02918 HuMAP2_04182 HuMAP2_06718 HuMAP2_06752 |
| PIK3C2A | HuMAP2_01874 HuMAP2_02565 HuMAP2_04785 HuMAP2_05305 HuMAP2_06718 |
| GAK | HuMAP2_00017 HuMAP2_02565 HuMAP2_04182 HuMAP2_05488 HuMAP2_06718 |