hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06727

Confidence: Medium

Genename	Protein Name	Links
GNG3	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	UniProt NCBI
GNAT2	Guanine nucleotide-binding protein G(t) subunit alpha-2 (Transducin alpha-2 chain)	UniProt NCBI
GNA11	Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)	UniProt NCBI
GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)	UniProt NCBI
GNA12	Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)	UniProt NCBI
GNAZ	Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha)	UniProt NCBI
GNA13	Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13)	UniProt NCBI
MTHFR	Methylenetetrahydrofolate reductase (EC 1.5.1.20)	UniProt NCBI
GNB4	Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:1905360	3.66740891982e-14	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	GTPase complex
GO:0005834	3.66740891982e-14	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	heterotrimeric G-protein complex
REAC:R-HSA-456926	4.14636766617e-13	0.666666666667	GNB4 GNG3 GNA12 GNAQ GNA11 GNA13	Thrombin signalling through proteinase activated receptors (PARs)
GO:0031683	2.21679144479e-12	0.666666666667	GNAZ GNAT2 GNA12 GNAQ GNA11 GNA13	G-protein beta/gamma-subunit complex binding
REAC:R-HSA-428930	8.33814755212e-11	0.555555555556	GNG3 GNB4 GNA13 GNAQ GNA11	Thromboxane signalling through TP receptor
GO:0031234	1.33270943358e-10	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	extrinsic component of cytoplasmic side of plasma membrane
WP:WP35	1.65367510443e-10	0.666666666667	GNA13 GNG3 GNA12 GNAQ GNA11 GNAZ	G Protein Signaling Pathways
REAC:R-HSA-392518	4.85735348072e-10	0.555555555556	GNG3 GNB4 GNA13 GNAQ GNA11	Signal amplification
KEGG:04730	2.9993225826e-09	0.555555555556	GNA11 GNA13 GNA12 GNAQ GNAZ	Long-term depression
GO:0019897	4.1485287179e-09	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	extrinsic component of plasma membrane
REAC:R-HSA-388396	4.784621891e-09	0.888888888889	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNB4 GNAT2	GPCR downstream signalling
GO:0009898	5.20699467998e-09	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	cytoplasmic side of plasma membrane
REAC:R-HSA-372790	9.23538361327e-09	0.888888888889	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNB4 GNAT2	Signaling by GPCR
GO:0098562	1.46846692242e-08	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	cytoplasmic side of membrane
KEGG:05163	2.40161285727e-08	0.666666666667	GNB4 GNG3 GNA12 GNAQ GNA11 GNA13	Human cytomegalovirus infection
REAC:R-HSA-418592	8.91499029266e-08	0.444444444444	GNG3 GNB4 GNA11 GNAQ	ADP signalling through P2Y purinoceptor 1
REAC:R-HSA-76002	1.6980163507e-07	0.666666666667	GNB4 GNG3 GNA12 GNAQ GNA11 GNA13	Platelet activation, signaling and aggregation
REAC:R-HSA-202040	1.8200385914e-07	0.444444444444	GNG3 GNB4 GNAZ GNAT2	G-protein activation
WP:WP536	2.2957661608e-07	0.555555555556	GNG3 GNB4 GNAZ GNAQ GNA11	Calcium Regulation in the Cardiac Cell
GO:0019898	2.52859517294e-07	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	extrinsic component of membrane
GO:0003924	5.39087736506e-07	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	GTPase activity
GO:0007188	6.51345510442e-07	0.666666666667	GNAZ GNAT2 GNA12 GNAQ GNA11 GNA13	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
REAC:R-HSA-6814122	9.97842063177e-07	0.444444444444	GNG3 GNB4 GNAZ GNAT2	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
GO:0007187	1.40372585517e-06	0.666666666667	GNAZ GNAT2 GNA12 GNAQ GNA11 GNA13	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0098552	2.8756814872e-06	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	side of membrane
KEGG:05200	3.56042421268e-06	0.666666666667	GNB4 GNG3 GNA12 GNAQ GNA11 GNA13	Pathways in cancer
GO:0001664	3.71276643052e-06	0.666666666667	GNAZ GNAT2 GNA12 GNAQ GNA11 GNA13	G protein-coupled receptor binding
KEGG:04725	1.01958736136e-05	0.444444444444	GNG3 GNB4 GNA11 GNAQ	Cholinergic synapse
REAC:R-HSA-422356	1.04034613479e-05	0.444444444444	GNG3 GNB4 GNA11 GNAQ	Regulation of insulin secretion
KEGG:04928	1.06315372234e-05	0.444444444444	GNA11 GNA12 GNAQ GNA13	Parathyroid hormone synthesis, secretion and action
KEGG:04270	1.15444043478e-05	0.444444444444	GNA11 GNA12 GNAQ GNA13	Vascular smooth muscle contraction
REAC:R-HSA-416482	1.30841265756e-05	0.444444444444	GNG3 GNB4 GNA12 GNA13	G alpha (12/13) signalling events
GO:0098797	1.58765085867e-05	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	plasma membrane protein complex
GO:0044877	2.27609661353e-05	0.888888888889	GNAZ MTHFR GNAT2 GNA12 GNAQ GNA11 GNB4 GNA13	protein-containing complex binding
REAC:R-HSA-111885	2.54381639401e-05	0.444444444444	GNG3 GNB4 GNAZ GNAT2	Opioid Signalling
KEGG:04371	2.85764445803e-05	0.444444444444	GNG3 GNB4 GNA13 GNAQ	Apelin signaling pathway
REAC:R-HSA-390466	3.05757392315e-05	0.444444444444	GNG3 GNB4 GNAZ GNAT2	Chaperonin-mediated protein folding
REAC:R-HSA-109582	3.2239468963e-05	0.666666666667	GNB4 GNG3 GNA12 GNAQ GNA11 GNA13	Hemostasis
REAC:R-HSA-391251	3.96867271734e-05	0.444444444444	GNG3 GNB4 GNAZ GNAT2	Protein folding
CORUM:7155	4.02261743042e-05	0.222222222222	GNG3 GNB4	GNAS-L-GNB4-GNG3 complex
CORUM:7027	4.02261743042e-05	0.222222222222	GNG3 GNB4	GNAI1-GNB4-GNG3 complex
REAC:R-HSA-163685	4.13825173994e-05	0.444444444444	GNG3 GNB4 GNA11 GNAQ	Integration of energy metabolism
KEGG:04022	4.78390127337e-05	0.444444444444	GNA11 GNA12 GNAQ GNA13	cGMP-PKG signaling pathway
CORUM:117	8.0427137187e-05	0.222222222222	GNA11 GNAQ	GPR56-CD81-Galpha(q/11)-Gbeta complex
GO:0007186	0.000123914389583	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	G protein-coupled receptor signaling pathway
REAC:R-HSA-162582	0.000143548616456	0.888888888889	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNB4 GNAT2	Signal Transduction
REAC:R-HSA-416476	0.000147346986949	0.444444444444	GNG3 GNB4 GNA11 GNAQ	G alpha (q) signalling events
KEGG:05170	0.000189218557965	0.444444444444	GNG3 GNB4 GNA11 GNAQ	Human immunodeficiency virus 1 infection
GO:0017111	0.000210054058214	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	nucleoside-triphosphatase activity
GO:0016462	0.00033524340405	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	pyrophosphatase activity
GO:0016818	0.000342891718175	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016817	0.000342891718175	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	hydrolase activity, acting on acid anhydrides
WP:WP2032	0.000391654898324	0.333333333333	GNA12 GNAQ GNA13	Human Thyroid Stimulating Hormone (TSH) signaling pathway
REAC:R-HSA-418597	0.000397570429893	0.333333333333	GNG3 GNAZ GNB4	G alpha (z) signalling events
REAC:R-HSA-4086398	0.000701309789929	0.333333333333	GNG3 GNAT2 GNB4	Ca2+ pathway
KEGG:04713	0.000835094366543	0.333333333333	GNG3 GNAQ GNB4	Circadian entrainment
WP:WP2355	0.000849456213585	0.333333333333	GNAZ GNAQ GNA11	Corticotropin-releasing hormone signaling pathway
KEGG:04726	0.00105110969134	0.333333333333	GNG3 GNAQ GNB4	Serotonergic synapse
KEGG:04724	0.00122607355355	0.333333333333	GNG3 GNAQ GNB4	Glutamatergic synapse
HP:0030786	0.00135162272217	0.222222222222	GNA11 GNAQ	Photopsia
HP:0030800	0.00135162272217	0.222222222222	GNA11 GNAQ	Abnormal visual accommodation
HP:0012055	0.00135162272217	0.222222222222	GNA11 GNAQ	Ciliary body melanoma
HP:0011524	0.00135162272217	0.222222222222	GNA11 GNAQ	Iris melanoma
HP:0012054	0.00135162272217	0.222222222222	GNA11 GNAQ	Choroidal melanoma
HP:0008494	0.00135162272217	0.222222222222	GNA11 GNAQ	Inferior lens subluxation
HP:0007716	0.00135162272217	0.222222222222	GNA11 GNAQ	Uveal melanoma
REAC:R-HSA-434316	0.00135573230455	0.222222222222	GNA11 GNAQ	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
KEGG:04071	0.00158746415424	0.333333333333	GNA12 GNAQ GNA13	Sphingolipid signaling pathway
REAC:R-HSA-418594	0.00215858652987	0.444444444444	GNG3 GNB4 GNAZ GNAT2	G alpha (i) signalling events
KEGG:04728	0.00216971375766	0.333333333333	GNG3 GNAQ GNB4	Dopaminergic synapse
HP:0012776	0.00225199859711	0.222222222222	GNA11 GNAQ	Abnormal ciliary body morphology
KEGG:04723	0.00281337490649	0.333333333333	GNG3 GNAQ GNB4	Retrograde endocannabinoid signaling
REAC:R-HSA-400451	0.00290241019689	0.222222222222	GNA11 GNAQ	Free fatty acids regulate insulin secretion
REAC:R-HSA-399997	0.00290241019689	0.222222222222	GNA11 GNAQ	Acetylcholine regulates insulin secretion
WP:WP289	0.00321797971369	0.333333333333	GNG3 GNAQ GNB4	Myometrial Relaxation and Contraction Pathways
GO:0098796	0.0035636193426	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	membrane protein complex
HP:0200026	0.00472623345058	0.222222222222	GNA11 GNAQ	Ocular pain
HP:0011499	0.00472623345058	0.222222222222	GNA11 GNAQ	Mydriasis
HP:0012508	0.00629966976086	0.222222222222	GNA11 GNAQ	Metamorphopsia
HP:0001132	0.00629966976086	0.222222222222	GNA11 GNAQ	Lens subluxation
REAC:R-HSA-8964315	0.00772521789112	0.222222222222	GNG3 GNB4	G beta:gamma signalling through BTK
HP:0007902	0.00809703709436	0.222222222222	GNA11 GNAQ	Vitreous hemorrhage
REAC:R-HSA-392851	0.00875250290708	0.222222222222	GNG3 GNB4	Prostacyclin signalling through prostacyclin receptor
REAC:R-HSA-418217	0.00984347966308	0.222222222222	GNG3 GNB4	G beta:gamma signalling through PLC beta
REAC:R-HSA-8964616	0.00984347966308	0.222222222222	GNG3 GNB4	G beta:gamma signalling through CDC42
REAC:R-HSA-500657	0.010998087958	0.222222222222	GNG3 GNB4	Presynaptic function of Kainate receptors
REAC:R-HSA-392170	0.0122162676274	0.222222222222	GNG3 GNB4	ADP signalling through P2Y purinoceptor 12
REAC:R-HSA-3858494	0.0122347169134	0.333333333333	GNG3 GNAT2 GNB4	Beta-catenin independent WNT signaling
REAC:R-HSA-392451	0.0134979585429	0.222222222222	GNG3 GNB4	G beta:gamma signalling through PI3Kgamma
REAC:R-HSA-420092	0.0134979585429	0.222222222222	GNG3 GNB4	Glucagon-type ligand receptors
GO:0031826	0.0162296428096	0.222222222222	GNA11 GNAQ	type 2A serotonin receptor binding
GO:0031752	0.0162296428096	0.222222222222	GNA12 GNA13	D5 dopamine receptor binding
GO:0030168	0.0172464333604	0.444444444444	GNA11 GNA12 GNAQ GNA13	platelet activation
HP:0007906	0.0175215982818	0.222222222222	GNA11 GNAQ	Ocular hypertension
KEGG:00000	0.0200811167769	1.0	GNAZ MTHFR GNA13 GNG3 GNA12 GNAQ GNA11 GNB4 GNAT2	KEGG root term
HP:0012633	0.0204354580639	0.222222222222	GNA11 GNAQ	Asymmetry of intraocular pressure
HP:0012632	0.0204354580639	0.222222222222	GNA11 GNAQ	Abnormal intraocular pressure
REAC:R-HSA-400042	0.0208569798789	0.222222222222	GNG3 GNB4	Adrenaline,noradrenaline inhibits insulin secretion
REAC:R-HSA-451326	0.0225184776205	0.222222222222	GNG3 GNB4	Activation of kainate receptors upon glutamate binding
KEGG:04929	0.0233869750354	0.222222222222	GNA11 GNAQ	GnRH secretion
REAC:R-HSA-397795	0.0242430667307	0.222222222222	GNG3 GNB4	G-protein beta:gamma signalling
REAC:R-HSA-418555	0.0257605531651	0.333333333333	GNG3 GNAZ GNB4	G alpha (s) signalling events
KEGG:04927	0.0260590585698	0.222222222222	GNA11 GNAQ	Cortisol synthesis and secretion
GO:0009584	0.027657204222	0.333333333333	GNAT2 GNAQ GNA11	detection of visible light
REAC:R-HSA-163359	0.0297947840849	0.222222222222	GNG3 GNB4	Glucagon signaling in metabolic regulation
GO:1902494	0.0328019970767	0.777777777778	GNAZ GNA13 GNG3 GNA12 GNAQ GNA11 GNAT2	catalytic complex
GO:0001750	0.0375082902074	0.333333333333	GNAT2 GNAQ GNA11	photoreceptor outer segment
REAC:R-HSA-381676	0.0380767270881	0.222222222222	GNG3 GNB4	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
GO:0007602	0.0412466387549	0.333333333333	GNAT2 GNAQ GNA11	phototransduction
KEGG:04911	0.041537807514	0.222222222222	GNA11 GNAQ	Insulin secretion
REAC:R-HSA-432040	0.0425936191784	0.222222222222	GNG3 GNB4	Vasopressin regulates renal water homeostasis via Aquaporins
HP:0007686	0.0470553832537	0.222222222222	GNA11 GNAQ	Abnormal pupillary function
REAC:R-HSA-445717	0.0473604898263	0.222222222222	GNG3 GNB4	Aquaporin-mediated transport
CORUM:3110	0.0499262710315	0.111111111111	GNA12	ITGAV-P2RY2-GNA12 complex
CORUM:7017	0.0499262710315	0.111111111111	GNB4	GNAI1-GNB4-GNGT1 complex
CORUM:7145	0.0499262710315	0.111111111111	GNB4	GNAS-L-GNB4-GNG1 complex
KEGG:04727	0.0499598185166	0.222222222222	GNG3 GNB4	GABAergic synapse

Edges

Protein 1	Protein 2	Score	Precision	Evidence
GNG3	GNAQ	0.251	0.474	bioplex (GNG3) bioplex_WMM
GNG3	GNA13	0.165	0.421	bioplex (GNG3) bioplex_WMM
GNA11	GNG3	0.154	0.413	bioplex (GNG3) bioplex_WMM
GNA11	GNB4	0.1	0.361	bioplex_WMM Guru gupta_WMM fraction
GNAZ	GNG3	0.086	0.352	bioplex (GNG3) bioplex_WMM
GNB4	GNG3	0.054	0.304	bioplex (GNG3) bioplex_WMM
MTHFR	GNAZ	0.046	0.293	bioplex (GNAZ) bioplex_WMM
GNAT2	GNG3	0.034	0.263	bioplex (GNG3) bioplex_WMM
GNA12	GNG3	0.02	0.188	bioplex (GNG3) bioplex_WMM
GNB4	GNAQ	0.02	0.188	hein_WMM bioplex_WMM Guru fraction
GNAZ	GNAQ	0.014	0.143	bioplex_WMM WMM_only
GNAZ	GNA11	0.011	0.141	bioplex_WMM WMM_only
GNA11	GNAQ	0.011	0.138	bioplex_WMM WMM_only
GNAT2	GNA12	0.009	0.111	bioplex_WMM WMM_only
GNB4	GNA12	0.008	0.09	bioplex_WMM WMM_only
GNAZ	GNA12	0.007	0.007	bioplex (GNAZ) bioplex_WMM
GNAZ	GNAT2	0.007	0.008	bioplex_WMM WMM_only
MTHFR	GNA12	0.007	0.01	bioplex_WMM WMM_only
GNB4	GNAT2	0.007	0.007	bioplex_WMM WMM_only
MTHFR	GNAT2	0.007	0.002	bioplex_WMM WMM_only
GNA11	GNAT2	0.007	0.0	bioplex_WMM WMM_only
GNAT2	GNA13	0.007	0.003	bioplex_WMM WMM_only
GNAT2	GNAQ	0.007	0.0	bioplex_WMM WMM_only
MTHFR	GNA11	0.007	0.0	bioplex_WMM WMM_only
MTHFR	GNAQ	0.007	0.003	bioplex_WMM WMM_only
GNA11	GNA12	0.007	0.004	bioplex_WMM WMM_only
GNA12	GNA13	0.007	0.002	bioplex_WMM WMM_only
GNA12	GNAQ	0.007	0.003	bioplex_WMM WMM_only
GNAZ	GNA13	0.007	0.002	bioplex_WMM WMM_only
MTHFR	GNA13	0.006	0.006	bioplex_WMM WMM_only
MTHFR	GNB4	0.006	0.002	bioplex_WMM WMM_only
GNA13	GNAQ	0.006	0.004	bioplex_WMM WMM_only
GNA11	GNA13	0.005	0.013	bioplex_WMM youn_WMM WMM_only
GNB4	GNA13	0.003	0.012	bioplex_WMM gupta_WMM WMM_only
GNAZ	GNB4	0.0	0.001	bioplex (GNAZ) bioplex_WMM

Images

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Complex HuMAP2_06727 has an average edge precision of 0.113 which is ranked 6897 out of all 6965 complexes.

Related Complexes

Genename	Complexes
GNG3	HuMAP2_03496 HuMAP2_05767 HuMAP2_06727
GNAT2	HuMAP2_02337 HuMAP2_06727
GNA11	HuMAP2_01804 HuMAP2_03496 HuMAP2_05902 HuMAP2_06727
GNAQ	HuMAP2_03496 HuMAP2_05767 HuMAP2_06727
GNA12	HuMAP2_03216 HuMAP2_06032 HuMAP2_06727
GNAZ	HuMAP2_00093 HuMAP2_03496 HuMAP2_05767 HuMAP2_06727
GNA13	HuMAP2_03496 HuMAP2_05767 HuMAP2_06727
MTHFR	HuMAP2_00093 HuMAP2_05767 HuMAP2_06727
GNB4	HuMAP2_01804 HuMAP2_03496 HuMAP2_05902 HuMAP2_06727

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06727