hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06736
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RCAN1 | Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1) | UniProt NCBI |
| PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | UniProt NCBI |
| SIK3 | Serine/threonine-protein kinase SIK3 (EC 2.7.11.1) (Salt-inducible kinase 3) (SIK-3) (Serine/threonine-protein kinase QSK) | UniProt NCBI |
| PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform) | UniProt NCBI |
| RCAN2 | Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4) | UniProt NCBI |
| PPP3CA | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform) | UniProt NCBI |
| NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) | UniProt NCBI |
| PPP3R1 | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | UniProt NCBI |
| NFATC4 | Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T-cell transcription factor NFAT3) (NF-AT3) | UniProt NCBI |
| RCAN3 | Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0033173 | 2.64106893615e-19 | 0.9 | RCAN3 NFATC4 NFATC1 RCAN2 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | calcineurin-NFAT signaling cascade |
| GO:0097720 | 2.64106893615e-19 | 0.9 | RCAN3 NFATC4 NFATC1 RCAN2 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | calcineurin-mediated signaling |
| GO:0048016 | 8.20610848142e-19 | 0.9 | RCAN3 NFATC4 NFATC1 RCAN2 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | inositol phosphate-mediated signaling |
| GO:0019722 | 1.45996319487e-13 | 0.9 | RCAN3 NFATC4 NFATC1 RCAN2 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | calcium-mediated signaling |
| WP:WP3414 | 5.11067688451e-13 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | Initiation of transcription and translation elongation at the HIV-1 LTR |
| KEGG:04921 | 2.42371133439e-11 | 0.7 | NFATC4 NFATC1 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | Oxytocin signaling pathway |
| GO:0019932 | 4.68355000131e-11 | 0.9 | RCAN3 NFATC4 NFATC1 RCAN2 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | second-messenger-mediated signaling |
| KEGG:05167 | 1.01127542738e-10 | 0.7 | NFATC4 NFATC1 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04625 | 3.5447197415e-10 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | C-type lectin receptor signaling pathway |
| REAC:R-HSA-2025928 | 7.49514718539e-10 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Calcineurin activates NFAT |
| WP:WP428 | 1.52807918879e-09 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | Wnt Signaling |
| REAC:R-HSA-5607763 | 2.69651336899e-09 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | CLEC7A (Dectin-1) induces NFAT activation |
| GO:0005955 | 5.12306788392e-09 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | calcineurin complex |
| KEGG:04022 | 6.33101443908e-09 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | cGMP-PKG signaling pathway |
| KEGG:04218 | 7.50363581653e-09 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | Cellular senescence |
| KEGG:04310 | 8.1544227329e-09 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | Wnt signaling pathway |
| CORUM:2266 | 1.62176028613e-08 | 0.3 | RCAN1 PPP3CB PPP3CA | PPP3CA-PPP3CA-RCAN1 complex |
| KEGG:04662 | 1.88398287368e-08 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | B cell receptor signaling pathway |
| KEGG:04658 | 2.53703102185e-08 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | Th1 and Th2 cell differentiation |
| KEGG:05235 | 4.67255896417e-08 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:05166 | 4.79445231967e-08 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | Human T-cell leukemia virus 1 infection |
| KEGG:05170 | 5.09561484523e-08 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 5.57671377236e-08 | 0.6 | NFATC4 NFATC1 PPP3CA PPP3R1 PPP3CC PPP3CB | Human cytomegalovirus infection |
| KEGG:04659 | 6.75764334327e-08 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | Th17 cell differentiation |
| KEGG:04660 | 8.51826881094e-08 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | T cell receptor signaling pathway |
| KEGG:04650 | 1.38276208947e-07 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | Natural killer cell mediated cytotoxicity |
| KEGG:04380 | 1.69053847963e-07 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | Osteoclast differentiation |
| GO:0004723 | 1.79134017731e-07 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | calcium-dependent protein serine/threonine phosphatase activity |
| REAC:R-HSA-180024 | 1.88651086328e-07 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | DARPP-32 events |
| REAC:R-HSA-2871809 | 1.88651086328e-07 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | FCERI mediated Ca+2 mobilization |
| WP:WP1541 | 9.40423428506e-07 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Energy Metabolism |
| KEGG:05014 | 1.21248250754e-06 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Amyotrophic lateral sclerosis (ALS) |
| KEGG:04924 | 1.41983136015e-06 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Renin secretion |
| KEGG:04370 | 1.65261768545e-06 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | VEGF signaling pathway |
| KEGG:04360 | 1.81929360219e-06 | 0.5 | PPP3CA PPP3CC PPP3R1 NFATC4 PPP3CB | Axon guidance |
| KEGG:04720 | 2.6969885458e-06 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Long-term potentiation |
| KEGG:05031 | 2.6969885458e-06 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Amphetamine addiction |
| REAC:R-HSA-4086398 | 6.17834566759e-06 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Ca2+ pathway |
| WP:WP1544 | 8.01712879561e-06 | 0.4 | PPP3CA RCAN1 NFATC4 PPP3CB | MicroRNAs in cardiomyocyte hypertrophy |
| WP:WP382 | 9.7291486674e-06 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | MAPK Signaling Pathway |
| WP:WP2059 | 9.87029161151e-06 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Alzheimers Disease |
| GO:0008597 | 1.08982291228e-05 | 0.3 | RCAN1 RCAN2 RCAN3 | calcium-dependent protein serine/threonine phosphatase regulator activity |
| KEGG:04922 | 1.58848840612e-05 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Glucagon signaling pathway |
| KEGG:04010 | 1.6293211496e-05 | 0.5 | PPP3CC PPP3R1 NFATC1 PPP3CB PPP3CA | MAPK signaling pathway |
| WP:WP4482 | 1.79811631963e-05 | 0.3 | PPP3CA PPP3R1 NFATC1 | Vitamin D in inflammatory diseases |
| KEGG:04724 | 1.87261754488e-05 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Glutamatergic synapse |
| WP:WP1528 | 2.39264488914e-05 | 0.3 | PPP3CA NFATC4 PPP3CB | Physiological and Pathological Hypertrophy of the Heart |
| KEGG:04114 | 2.45891810789e-05 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Oocyte meiosis |
| REAC:R-HSA-1168372 | 2.83322384275e-05 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Downstream signaling events of B Cell Receptor (BCR) |
| CORUM:6023 | 3.01890677263e-05 | 0.2 | PPP3CA PPP3R1 | Calcineurin |
| REAC:R-HSA-111885 | 4.43296189167e-05 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Opioid Signalling |
| REAC:R-HSA-5607764 | 5.82153902075e-05 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-983705 | 8.48190823622e-05 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Signaling by the B Cell Receptor (BCR) |
| GO:0035556 | 8.49439681848e-05 | 1.0 | RCAN3 NFATC4 NFATC1 RCAN2 SIK3 PPP3CA PPP3R1 RCAN1 PPP3CC PPP3CB | intracellular signal transduction |
| CORUM:6374 | 9.0534767973e-05 | 0.2 | PPP3CA PPP3R1 | Calcineurin-FKBP12 complex |
| KEGG:05152 | 9.51996866649e-05 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Tuberculosis |
| KEGG:05010 | 0.000105742119328 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Alzheimer disease |
| GO:0033192 | 0.000108905457596 | 0.3 | PPP3CC PPP3CB PPP3CA | calmodulin-dependent protein phosphatase activity |
| WP:WP2447 | 0.000113369764245 | 0.3 | PPP3CC PPP3CB PPP3CA | Amyotrophic lateral sclerosis (ALS) |
| KEGG:04020 | 0.000120112755059 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | Calcium signaling pathway |
| REAC:R-HSA-2454202 | 0.000169603393017 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-5621481 | 0.000206253548648 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | C-type lectin receptors (CLRs) |
| GO:0007223 | 0.000207683806831 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Wnt signaling pathway, calcium modulating pathway |
| REAC:R-HSA-3858494 | 0.00028836564474 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Beta-catenin independent WNT signaling |
| GO:0008287 | 0.000416645725181 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | protein serine/threonine phosphatase complex |
| GO:1903293 | 0.000416645725181 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | phosphatase complex |
| WP:WP3888 | 0.000556234612026 | 0.4 | RCAN1 NFATC1 RCAN2 PPP3CA | VEGFA-VEGFR2 Signaling Pathway |
| KEGG:04728 | 0.00289455783846 | 0.3 | PPP3CC PPP3CB PPP3CA | Dopaminergic synapse |
| GO:0004722 | 0.00361912811657 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | protein serine/threonine phosphatase activity |
| REAC:R-HSA-418594 | 0.0037262475025 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | G alpha (i) signalling events |
| WP:WP4585 | 0.00385290915917 | 0.2 | NFATC1 NFATC4 | Cancer immunotherapy by PD-1 blockade |
| REAC:R-HSA-195721 | 0.00732493957487 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Signaling by WNT |
| REAC:R-HSA-111447 | 0.00887131457927 | 0.2 | PPP3CC PPP3R1 | Activation of BAD and translocation to mitochondria |
| GO:0005516 | 0.0096328411906 | 0.4 | PPP3CC PPP3R1 PPP3CB PPP3CA | calmodulin binding |
| WP:WP1591 | 0.0157629453401 | 0.2 | NFATC1 NFATC4 | Heart Development |
| GO:0010646 | 0.0205035569661 | 0.9 | RCAN3 NFATC4 NFATC1 RCAN2 SIK3 PPP3R1 RCAN1 PPP3CC PPP3CB | regulation of cell communication |
| GO:0038095 | 0.0210923497616 | 0.4 | PPP3CA PPP3R1 PPP3CB NFATC1 | Fc-epsilon receptor signaling pathway |
| GO:0023051 | 0.0238084737166 | 0.9 | RCAN3 NFATC4 NFATC1 RCAN2 SIK3 PPP3R1 RCAN1 PPP3CC PPP3CB | regulation of signaling |
| GO:0106056 | 0.0248721634083 | 0.3 | RCAN1 RCAN2 RCAN3 | regulation of calcineurin-mediated signaling |
| GO:0070884 | 0.0248721634083 | 0.3 | RCAN1 RCAN2 RCAN3 | regulation of calcineurin-NFAT signaling cascade |
| REAC:R-HSA-114452 | 0.0365556262578 | 0.2 | PPP3CC PPP3R1 | Activation of BH3-only proteins |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP3CC | SIK3 | 1.0 | 0.949 | bioplex (PPP3CC) bioplex_WMM |
| RCAN3 | PPP3R1 | 0.981 | 0.896 | bioplex (RCAN3) bioplex_WMM |
| PPP3CC | RCAN3 | 0.958 | 0.863 | bioplex (PPP3CC,RCAN3) bioplex_WMM |
| PPP3CC | RCAN1 | 0.931 | 0.846 | bioplex (PPP3CC,RCAN1) bioplex_WMM |
| PPP3CC | PPP3R1 | 0.929 | 0.845 | bioplex (PPP3CC) bioplex_WMM |
| PPP3CB | RCAN3 | 0.878 | 0.812 | bioplex (RCAN3) bioplex_WMM |
| PPP3CC | PPP3CB | 0.833 | 0.78 | bioplex (PPP3CC) bioplex_WMM |
| PPP3CC | NFATC4 | 0.812 | 0.771 | bioplex (PPP3CC) bioplex_WMM |
| PPP3CA | RCAN3 | 0.806 | 0.768 | bioplex (PPP3CA,RCAN3) bioplex_WMM |
| PPP3CA | RCAN1 | 0.574 | 0.657 | bioplex (PPP3CA,RCAN1) bioplex_WMM |
| PPP3CC | NFATC1 | 0.404 | 0.562 | bioplex (NFATC1,PPP3CC) bioplex_WMM |
| PPP3CA | PPP3R1 | 0.224 | 0.466 | bioplex (PPP3CA) bioplex_WMM |
| PPP3CB | RCAN1 | 0.215 | 0.464 | bioplex (RCAN1) bioplex_WMM |
| PPP3CC | RCAN2 | 0.099 | 0.359 | bioplex (RCAN2) bioplex_WMM |
| PPP3CB | RCAN2 | 0.05 | 0.295 | bioplex (RCAN2) bioplex_WMM |
| PPP3R1 | RCAN1 | 0.041 | 0.271 | bioplex (RCAN1) bioplex_WMM |
| PPP3CB | PPP3CA | 0.037 | 0.266 | bioplex_WMM gupta_WMM WMM_only |
| PPP3CC | PPP3CA | 0.031 | 0.238 | bioplex_WMM WMM_only |
| PPP3CB | PPP3R1 | 0.026 | 0.219 | bioplex_WMM WMM_only |
| PPP3R1 | RCAN2 | 0.016 | 0.158 | bioplex (RCAN2) bioplex_WMM |
| NFATC4 | SIK3 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| RCAN3 | NFATC4 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| RCAN3 | SIK3 | 0.011 | 0.143 | bioplex_WMM WMM_only |
| RCAN1 | NFATC4 | 0.011 | 0.134 | bioplex_WMM WMM_only |
| PPP3CA | RCAN2 | 0.011 | 0.143 | bioplex (RCAN2) bioplex_WMM |
| RCAN1 | SIK3 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| RCAN3 | RCAN1 | 0.01 | 0.131 | bioplex_WMM WMM_only |
| PPP3R1 | NFATC4 | 0.009 | 0.11 | bioplex_WMM WMM_only |
| PPP3R1 | SIK3 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| NFATC4 | NFATC1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| NFATC1 | SIK3 | 0.009 | 0.096 | bioplex_WMM youn_WMM WMM_only |
| RCAN3 | NFATC1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| RCAN1 | NFATC1 | 0.008 | 0.081 | bioplex_WMM WMM_only |
| PPP3CA | NFATC4 | 0.008 | 0.071 | bioplex (PPP3CA) bioplex_WMM |
| PPP3CB | NFATC4 | 0.008 | 0.015 | bioplex_WMM WMM_only |
| PPP3CB | SIK3 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| PPP3R1 | NFATC1 | 0.007 | 0.011 | bioplex (NFATC1) bioplex_WMM |
| PPP3CB | NFATC1 | 0.006 | 0.006 | bioplex (NFATC1) bioplex_WMM |
| PPP3CA | NFATC1 | 0.006 | 0.005 | bioplex (NFATC1) bioplex_WMM |
| PPP3CA | SIK3 | 0.005 | 0.007 | bioplex (PPP3CA) bioplex_WMM |
Images
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Complex HuMAP2_06736 has an average edge precision of 0.329 which is ranked 4231 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RCAN1 | HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| PPP3CB | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| SIK3 | HuMAP2_06203 HuMAP2_06736 |
| PPP3CC | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| RCAN2 | HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| PPP3CA | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| NFATC1 | HuMAP2_06203 HuMAP2_06736 |
| PPP3R1 | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |
| NFATC4 | HuMAP2_06203 HuMAP2_06736 |
| RCAN3 | HuMAP2_02758 HuMAP2_04373 HuMAP2_06203 HuMAP2_06736 |