hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06751
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IGF2BP1 | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2 mRNA-binding protein 1) (IMP-1) (IMP1) (Coding region determinant-binding protein) (CRD-BP) (IGF-II mRNA-binding protein 1) (VICKZ family member 1) (Zipcode-binding protein 1) (ZBP-1) | UniProt NCBI |
| IGF2BP3 | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3) | UniProt NCBI |
| YBX3 | Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB) | UniProt NCBI |
| IGF2BP2 | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428359 | 1.350462097e-09 | 0.75 | IGF2BP2 IGF2BP1 IGF2BP3 | Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA |
| GO:0003730 | 2.80701671762e-05 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | mRNA 3'-UTR binding |
| GO:0043488 | 0.000625429030777 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | regulation of mRNA stability |
| GO:0048027 | 0.00064271072446 | 0.75 | IGF2BP2 IGF2BP1 IGF2BP3 | mRNA 5'-UTR binding |
| GO:0043487 | 0.000691429733885 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | regulation of RNA stability |
| GO:0061013 | 0.000986378413477 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | regulation of mRNA catabolic process |
| GO:0003729 | 0.00219212488605 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | mRNA binding |
| GO:0006417 | 0.00393880365476 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | regulation of translation |
| GO:1903311 | 0.00665909549353 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | regulation of mRNA metabolic process |
| GO:0034248 | 0.00754257074571 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | regulation of cellular amide metabolic process |
| GO:0042035 | 0.00898751047669 | 0.75 | IGF2BP2 IGF2BP1 IGF2BP3 | regulation of cytokine biosynthetic process |
| GO:0042089 | 0.0106004966657 | 0.75 | IGF2BP2 IGF2BP1 IGF2BP3 | cytokine biosynthetic process |
| GO:0042107 | 0.0106004966657 | 0.75 | IGF2BP2 IGF2BP1 IGF2BP3 | cytokine metabolic process |
| MIRNA:hsa-miR-5195-5p | 0.0113006207749 | 0.5 | IGF2BP1 IGF2BP3 | hsa-miR-5195-5p |
| GO:0006402 | 0.0128783441389 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | mRNA catabolic process |
| GO:0006401 | 0.0181401540934 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | RNA catabolic process |
| WP:WP3302 | 0.0333519728792 | 0.25 | IGF2BP1 | eIF5A regulation in response to inhibition of the nuclear export system |
| GO:0034655 | 0.0445306239544 | 1.0 | IGF2BP2 IGF2BP3 YBX3 IGF2BP1 | nucleobase-containing compound catabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IGF2BP1 | IGF2BP3 | 0.993 | 0.918 | hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
| YBX3 | IGF2BP3 | 0.583 | 0.664 | hein_WMM bioplex_WMM gupta_WMM fraction treiber_WMM |
| IGF2BP1 | YBX3 | 0.568 | 0.655 | youn (IGF2BP1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| IGF2BP2 | IGF2BP1 | 0.5 | 0.621 | youn (IGF2BP1,IGF2BP2) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| IGF2BP2 | IGF2BP3 | 0.034 | 0.263 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| IGF2BP2 | YBX3 | 0.011 | 0.138 | youn (IGF2BP2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_06751 has an average edge precision of 0.543 which is ranked 2246 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IGF2BP1 | HuMAP2_00556 HuMAP2_03425 HuMAP2_04560 HuMAP2_04632 HuMAP2_06751 |
| IGF2BP3 | HuMAP2_03425 HuMAP2_04560 HuMAP2_06751 |
| YBX3 | HuMAP2_01695 HuMAP2_02631 HuMAP2_03425 HuMAP2_03637 HuMAP2_05476 HuMAP2_06751 |
| IGF2BP2 | HuMAP2_00556 HuMAP2_00999 HuMAP2_04632 HuMAP2_06202 HuMAP2_06751 |