hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06753
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SEC13 | Protein SEC13 homolog (GATOR complex protein SEC13) (SEC13-like protein 1) (SEC13-related protein) | UniProt NCBI |
| NAPRT | Nicotinate phosphoribosyltransferase (NAPRTase) (EC 6.3.4.21) (FHA-HIT-interacting protein) (Nicotinate phosphoribosyltransferase domain-containing protein 1) | UniProt NCBI |
| SEH1L | Nucleoporin SEH1 (GATOR complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein) | UniProt NCBI |
| WDR24 | GATOR complex protein WDR24 (WD repeat-containing protein 24) | UniProt NCBI |
| CASTOR1 | Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3) | UniProt NCBI |
| SPDL1 | Protein Spindly (hSpindly) (Arsenite-related gene 1 protein) (Coiled-coil domain-containing protein 99) (Rhabdomyosarcoma antigen MU-RMS-40.4A) (Spindle apparatus coiled-coil domain-containing protein 1) | UniProt NCBI |
| MIOS | GATOR complex protein MIOS (Missing oocyte meiosis regulator homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6216 | 4.54099480282e-12 | 0.571428571429 | SEC13 WDR24 MIOS SEH1L | GATOR2 complex |
| CORUM:6753 | 6.35431882484e-11 | 0.571428571429 | SEC13 WDR24 MIOS SEH1L | SOG complex |
| CORUM:6217 | 6.35431882484e-11 | 0.571428571429 | SEC13 WDR24 MIOS SEH1L | GATOR complex |
| GO:0061700 | 1.3614140283e-10 | 0.714285714286 | SEC13 CASTOR1 WDR24 MIOS SEH1L | GATOR2 complex |
| GO:0035859 | 1.0630951546e-09 | 0.714285714286 | SEC13 CASTOR1 WDR24 MIOS SEH1L | Seh1-associated complex |
| KEGG:04150 | 8.53938355673e-08 | 0.714285714286 | SEC13 CASTOR1 WDR24 MIOS SEH1L | mTOR signaling pathway |
| GO:0032006 | 4.10096921113e-06 | 0.714285714286 | SEC13 CASTOR1 WDR24 MIOS SEH1L | regulation of TOR signaling |
| GO:0031929 | 8.85279428958e-06 | 0.714285714286 | SEC13 CASTOR1 WDR24 MIOS SEH1L | TOR signaling |
| GO:0032008 | 3.94067359228e-05 | 0.571428571429 | SEC13 WDR24 MIOS SEH1L | positive regulation of TOR signaling |
| CORUM:87 | 0.000362009370683 | 0.285714285714 | SEC13 SEH1L | Nup 107-160 subcomplex |
| GO:0031669 | 0.0107359250842 | 0.571428571429 | SEH1L CASTOR1 MIOS WDR24 | cellular response to nutrient levels |
| GO:0031668 | 0.0147440727408 | 0.571428571429 | SEH1L CASTOR1 MIOS WDR24 | cellular response to extracellular stimulus |
| GO:0044437 | 0.0219979103469 | 0.714285714286 | SEC13 WDR24 SEH1L NAPRT MIOS | vacuolar part |
| GO:0034198 | 0.0225450636661 | 0.428571428571 | SEH1L MIOS WDR24 | cellular response to amino acid starvation |
| GO:1990928 | 0.0245293846287 | 0.428571428571 | SEH1L MIOS WDR24 | response to amino acid starvation |
| GO:0071496 | 0.0335643611827 | 0.571428571429 | SEH1L CASTOR1 MIOS WDR24 | cellular response to external stimulus |
| GO:0031667 | 0.041774596669 | 0.571428571429 | SEH1L CASTOR1 MIOS WDR24 | response to nutrient levels |
| GO:0005764 | 0.0423419678482 | 0.714285714286 | SEC13 WDR24 SEH1L NAPRT MIOS | lysosome |
| GO:0000323 | 0.0423419678482 | 0.714285714286 | SEC13 WDR24 SEH1L NAPRT MIOS | lytic vacuole |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SEC13 | WDR24 | 0.925 | 0.843 | hein_WMM bioplex (SEC13) bioplex_WMM boldt boldt_WMM |
| MIOS | SEC13 | 0.816 | 0.773 | hein_WMM bioplex (SEC13) bioplex_WMM boldt boldt_WMM |
| SEC13 | SEH1L | 0.517 | 0.631 | hein_WMM bioplex (SEC13) bioplex_WMM youn_WMM hein (SEH1L) boldt_WMM |
| MIOS | CASTOR1 | 0.248 | 0.472 | bioplex (CASTOR1) bioplex_WMM |
| SEC13 | NAPRT | 0.244 | 0.468 | fraction treiber_WMM |
| SEH1L | WDR24 | 0.069 | 0.348 | hein_WMM bioplex_WMM hein (SEH1L) boldt_WMM |
| SEC13 | SPDL1 | 0.047 | 0.294 | bioplex (SEC13) bioplex_WMM youn_WMM |
| MIOS | SEH1L | 0.045 | 0.283 | hein_WMM bioplex_WMM hein (SEH1L) boldt_WMM |
| WDR24 | CASTOR1 | 0.044 | 0.274 | bioplex (CASTOR1) bioplex_WMM |
| MIOS | WDR24 | 0.014 | 0.141 | hein_WMM bioplex_WMM boldt boldt_WMM |
| WDR24 | SPDL1 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| MIOS | SPDL1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| SPDL1 | NAPRT | 0.007 | 0.004 | gupta_WMM WMM_only |
| SEH1L | SPDL1 | 0.007 | 0.0 | bioplex_WMM youn_WMM WMM_only |
| SEC13 | CASTOR1 | 0.006 | 0.004 | bioplex (CASTOR1) |
| SEH1L | CASTOR1 | 0.004 | 0.01 | bioplex (CASTOR1) bioplex_WMM |
Images
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Complex HuMAP2_06753 has an average edge precision of 0.286 which is ranked 4796 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SEC13 | HuMAP2_00541 HuMAP2_01606 HuMAP2_03792 HuMAP2_05315 HuMAP2_06753 |
| NAPRT | HuMAP2_02938 HuMAP2_06753 HuMAP2_06793 |
| SEH1L | HuMAP2_00541 HuMAP2_05315 HuMAP2_06753 |
| WDR24 | HuMAP2_00541 HuMAP2_01606 HuMAP2_03326 HuMAP2_03792 HuMAP2_06753 HuMAP2_06823 |
| CASTOR1 | HuMAP2_03326 HuMAP2_05258 HuMAP2_06647 HuMAP2_06753 |
| SPDL1 | HuMAP2_01791 HuMAP2_02291 HuMAP2_04901 HuMAP2_06753 |
| MIOS | HuMAP2_00541 HuMAP2_01606 HuMAP2_03326 HuMAP2_03792 HuMAP2_06753 |