hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06774
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MLXIP | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) | UniProt NCBI |
| MLXIPL | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | UniProt NCBI |
| MLX | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04931 | 5.1634269878e-06 | 1.0 | MLX MLXIPL MLXIP | Insulin resistance |
| KEGG:04932 | 1.15269222189e-05 | 1.0 | MLX MLXIPL MLXIP | Non-alcoholic fatty liver disease (NAFLD) |
| WP:WP4396 | 2.70021017308e-05 | 1.0 | MLX MLXIPL MLXIP | Nonalcoholic fatty liver disease |
| REAC:R-HSA-163765 | 0.000140571869389 | 0.666666666667 | MLXIPL MLX | ChREBP activates metabolic gene expression |
| REAC:R-HSA-163685 | 0.03104119222 | 0.666666666667 | MLXIPL MLX | Integration of energy metabolism |
| HP:0001646 | 0.0462248590062 | 0.666666666667 | MLXIPL MLX | Abnormal aortic valve morphology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MLXIPL | MLX | 0.998 | 0.945 | bioplex (MLX) bioplex_WMM |
| MLXIP | MLX | 0.997 | 0.933 | bioplex (MLX) bioplex_WMM youn_WMM |
| MLXIPL | MLXIP | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06774 has an average edge precision of 0.656 which is ranked 1613 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MLXIP | HuMAP2_01462 HuMAP2_04173 HuMAP2_06774 |
| MLXIPL | HuMAP2_01462 HuMAP2_06774 HuMAP2_07010 |
| MLX | HuMAP2_01462 HuMAP2_01563 HuMAP2_04173 HuMAP2_06774 HuMAP2_07010 |