hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06789
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FAM193A | Protein FAM193A (Protein IT14) | UniProt NCBI |
| PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1) | UniProt NCBI |
| MDM4 | Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) | UniProt NCBI |
| TP73 | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | UniProt NCBI |
| MDM2 | E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2516 | 6.12580709064e-06 | 0.6 | TP73 MDM4 MDM2 | ATM Signaling Pathway |
| KEGG:04115 | 3.58157342459e-05 | 0.6 | TP73 MDM4 MDM2 | p53 signaling pathway |
| WP:WP1742 | 0.00045324857597 | 0.4 | TP73 MDM2 | TP53 Network |
| REAC:R-HSA-5633007 | 0.00169383519446 | 0.6 | TP73 MDM4 MDM2 | Regulation of TP53 Activity |
| REAC:R-HSA-6804760 | 0.00230284247734 | 0.4 | MDM2 MDM4 | Regulation of TP53 Activity through Methylation |
| WP:WP3998 | 0.00314132080553 | 0.4 | MDM2 MDM4 | Prader-Willi and Angelman Syndrome |
| WP:WP3959 | 0.00492385173449 | 0.4 | TP73 MDM2 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| REAC:R-HSA-2559585 | 0.00666792835349 | 0.4 | MDM2 MDM4 | Oncogene Induced Senescence |
| REAC:R-HSA-6804757 | 0.00799559968784 | 0.4 | MDM2 MDM4 | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.00846479084427 | 0.4 | MDM2 MDM4 | Regulation of TP53 Expression and Degradation |
| WP:WP254 | 0.00869264148791 | 0.4 | TP73 MDM2 | Apoptosis |
| WP:WP2261 | 0.0109715753892 | 0.4 | MDM2 MDM4 | Signaling Pathways in Glioblastoma |
| WP:WP710 | 0.0176422318434 | 0.4 | TP73 MDM2 | DNA Damage Response (only ATM dependent) |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | TP73 MDM4 MDM2 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-69541 | 0.0213836497757 | 0.4 | MDM2 MDM4 | Stabilization of p53 |
| REAC:R-HSA-69563 | 0.0287045163353 | 0.4 | MDM2 MDM4 | p53-Dependent G1 DNA Damage Response |
| REAC:R-HSA-69580 | 0.0287045163353 | 0.4 | MDM2 MDM4 | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69615 | 0.0304761248659 | 0.4 | MDM2 MDM4 | G1/S DNA Damage Checkpoints |
| CORUM:7180 | 0.0499494897235 | 0.2 | MDM2 | p53-MDM2 complex |
| CORUM:7249 | 0.0499494897235 | 0.2 | MDM2 | ERS1-MDM2 complex |
| CORUM:7250 | 0.0499494897235 | 0.2 | MDM4 | ESR1-MDM4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MDM4 | PELI1 | 0.331 | 0.521 | bioplex (MDM4) bioplex_WMM |
| MDM4 | FAM193A | 0.241 | 0.468 | bioplex (MDM4) bioplex_WMM |
| MDM4 | TP73 | 0.033 | 0.254 | bioplex (MDM4) bioplex_WMM |
| MDM4 | MDM2 | 0.03 | 0.231 | bioplex (MDM4) bioplex_WMM |
| PELI1 | FAM193A | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FAM193A | TP73 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| FAM193A | MDM2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| PELI1 | TP73 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| PELI1 | MDM2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| TP73 | MDM2 | 0.005 | 0.009 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06789 has an average edge precision of 0.159 which is ranked 6635 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FAM193A | HuMAP2_02416 HuMAP2_06789 |
| PELI1 | HuMAP2_02416 HuMAP2_06789 |
| MDM4 | HuMAP2_00320 HuMAP2_02416 HuMAP2_06789 |
| TP73 | HuMAP2_03619 HuMAP2_06789 |
| MDM2 | HuMAP2_06789 |