hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06794
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SYT1 | Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) | UniProt NCBI |
| SYT2 | Synaptotagmin-2 (Synaptotagmin II) (SytII) | UniProt NCBI |
| SYT5 | Synaptotagmin-5 (Synaptotagmin V) (SytV) | UniProt NCBI |
| VLDLR | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031045 | 7.26438828159e-06 | 0.75 | SYT2 SYT5 SYT1 | dense core granule |
| REAC:R-HSA-5250958 | 3.01639213985e-05 | 0.5 | SYT2 SYT1 | Toxicity of botulinum toxin type B (BoNT/B) |
| GO:0048791 | 5.99161085695e-05 | 0.75 | SYT2 SYT5 SYT1 | calcium ion-regulated exocytosis of neurotransmitter |
| REAC:R-HSA-168799 | 0.000361772624521 | 0.5 | SYT2 SYT1 | Neurotoxicity of clostridium toxins |
| GO:0014059 | 0.000413778117181 | 0.75 | SYT2 SYT5 SYT1 | regulation of dopamine secretion |
| GO:0014046 | 0.000413778117181 | 0.75 | SYT2 SYT5 SYT1 | dopamine secretion |
| GO:0015872 | 0.00106129291317 | 0.75 | SYT2 SYT5 SYT1 | dopamine transport |
| GO:0017158 | 0.00106129291317 | 0.75 | SYT2 SYT5 SYT1 | regulation of calcium ion-dependent exocytosis |
| GO:0050432 | 0.00106129291317 | 0.75 | SYT2 SYT5 SYT1 | catecholamine secretion |
| GO:0050433 | 0.00106129291317 | 0.75 | SYT2 SYT5 SYT1 | regulation of catecholamine secretion |
| REAC:R-HSA-5339562 | 0.00210807296175 | 0.5 | SYT2 SYT1 | Uptake and actions of bacterial toxins |
| GO:0051937 | 0.00237379826551 | 0.75 | SYT2 SYT5 SYT1 | catecholamine transport |
| GO:0140238 | 0.00237379826551 | 0.75 | SYT2 SYT5 SYT1 | presynaptic endocytosis |
| GO:0048488 | 0.00237379826551 | 0.75 | SYT2 SYT5 SYT1 | synaptic vesicle endocytosis |
| GO:0051952 | 0.00305917975424 | 0.75 | SYT2 SYT5 SYT1 | regulation of amine transport |
| GO:0001786 | 0.00358246159338 | 0.75 | SYT2 SYT5 SYT1 | phosphatidylserine binding |
| GO:0017156 | 0.00358246159338 | 0.75 | SYT2 SYT5 SYT1 | calcium-ion regulated exocytosis |
| GO:0030276 | 0.00386509246613 | 0.75 | SYT2 SYT5 SYT1 | clathrin binding |
| GO:0015837 | 0.00416219722544 | 0.75 | SYT2 SYT5 SYT1 | amine transport |
| GO:0036465 | 0.00447413621813 | 0.75 | SYT2 SYT5 SYT1 | synaptic vesicle recycling |
| GO:0005544 | 0.00447413621813 | 0.75 | SYT2 SYT5 SYT1 | calcium-dependent phospholipid binding |
| GO:0015844 | 0.00480126971785 | 0.75 | SYT2 SYT5 SYT1 | monoamine transport |
| GO:0099501 | 0.00710332146687 | 0.75 | SYT2 SYT5 SYT1 | exocytic vesicle membrane |
| GO:0030672 | 0.00710332146687 | 0.75 | SYT2 SYT5 SYT1 | synaptic vesicle membrane |
| GO:0016079 | 0.00848863295691 | 0.75 | SYT2 SYT5 SYT1 | synaptic vesicle exocytosis |
| GO:2001023 | 0.00848863295691 | 0.75 | SYT2 SYT5 SYT1 | regulation of response to drug |
| GO:0019905 | 0.00898751047669 | 0.75 | SYT2 SYT5 SYT1 | syntaxin binding |
| GO:0015696 | 0.00950554068334 | 0.75 | SYT2 SYT5 SYT1 | ammonium transport |
| GO:0072341 | 0.0111781410126 | 0.75 | SYT2 SYT5 SYT1 | modified amino acid binding |
| GO:0071277 | 0.011776375189 | 0.75 | SYT2 SYT5 SYT1 | cellular response to calcium ion |
| GO:0006897 | 0.0135035907885 | 1.0 | SYT2 SYT5 VLDLR SYT1 | endocytosis |
| REAC:R-HSA-6794361 | 0.0137933430055 | 0.5 | SYT2 SYT1 | Neurexins and neuroligins |
| GO:1903305 | 0.0225145500348 | 0.75 | SYT2 SYT5 SYT1 | regulation of regulated secretory pathway |
| REAC:R-HSA-6794362 | 0.0323499619092 | 0.5 | SYT2 SYT1 | Protein-protein interactions at synapses |
| HP:0010535 | 0.0386938410225 | 0.5 | SYT2 SYT1 | Sleep apnea |
| REAC:R-HSA-8856825 | 0.0390714342086 | 0.5 | SYT2 SYT1 | Cargo recognition for clathrin-mediated endocytosis |
| GO:0098657 | 0.0403998712414 | 1.0 | SYT2 SYT5 VLDLR SYT1 | import into cell |
| GO:0000149 | 0.0410761885593 | 0.75 | SYT2 SYT5 SYT1 | SNARE binding |
| GO:0051592 | 0.0439367749778 | 0.75 | SYT2 SYT5 SYT1 | response to calcium ion |
| GO:0099643 | 0.0469269676219 | 0.75 | SYT2 SYT5 SYT1 | signal release from synapse |
| GO:0007269 | 0.0469269676219 | 0.75 | SYT2 SYT5 SYT1 | neurotransmitter secretion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SYT2 | SYT1 | 0.999 | 0.949 | bioplex (SYT1) bioplex_WMM boldt_WMM |
| SYT1 | SYT5 | 0.977 | 0.893 | bioplex (SYT1,SYT5) bioplex_WMM |
| VLDLR | SYT1 | 0.051 | 0.296 | bioplex (SYT1) bioplex_WMM |
| SYT2 | SYT5 | 0.008 | 0.095 | bioplex_WMM WMM_only |
| VLDLR | SYT2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| VLDLR | SYT5 | 0.008 | 0.06 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06794 has an average edge precision of 0.396 which is ranked 3365 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SYT1 | HuMAP2_06300 HuMAP2_06794 |
| SYT2 | HuMAP2_06300 HuMAP2_06794 |
| SYT5 | HuMAP2_06300 HuMAP2_06794 |
| VLDLR | HuMAP2_03202 HuMAP2_06369 HuMAP2_06794 |