hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06797
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSP90AA1 | Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38) | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | UniProt NCBI |
| FBL | rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) | UniProt NCBI |
| CDC37 | Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5266 | 4.53902544858e-11 | 1.0 | HSP90AA1 CDC37 FBL HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 6 |
| CORUM:2112 | 2.70078815927e-09 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex |
| CORUM:5234 | 6.75163031135e-09 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex |
| CORUM:5269 | 1.3502580449e-08 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 8 |
| CORUM:5212 | 3.78034162849e-08 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | Kinase maturation complex 2 |
| CORUM:5268 | 3.78034162849e-08 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 7 |
| CORUM:5286 | 8.09991585269e-08 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | TNF-alpha/NF-kappa B signaling complex 10 |
| CORUM:5199 | 3.77881803953e-07 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | Kinase maturation complex 1 |
| CORUM:5849 | 1.50819606993e-05 | 0.5 | HSP90AB1 CDC37 | HSP90-CDC37-LRRK2 complex |
| CORUM:6512 | 1.50819606993e-05 | 0.5 | HSP90AA1 CDC37 | ILK-HSP90-CDC37 complex |
| CORUM:5285 | 5.02641999304e-05 | 0.5 | HSP90AB1 CDC37 | TNF-alpha/NF-kappa B signaling complex 9 |
| REAC:R-HSA-5336415 | 0.000100528399861 | 0.5 | HSP90AA1 HSP90AB1 | Uptake and function of diphtheria toxin |
| WP:WP3932 | 0.000615604541072 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP2882 | 0.000630139106445 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | Nuclear Receptors Meta-Pathway |
| REAC:R-HSA-3371511 | 0.000663071622452 | 0.5 | HSP90AA1 HSP90AB1 | HSF1 activation |
| REAC:R-HSA-5637812 | 0.000783559910601 | 0.5 | HSP90AA1 CDC37 | Signaling by EGFRvIII in Cancer |
| REAC:R-HSA-3371568 | 0.000783559910601 | 0.5 | HSP90AA1 HSP90AB1 | Attenuation phase |
| REAC:R-HSA-5637810 | 0.000783559910601 | 0.5 | HSP90AA1 CDC37 | Constitutive Signaling by EGFRvIII |
| WP:WP4172 | 0.000867148271367 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-9613829 | 0.00105460323216 | 0.5 | HSP90AA1 HSP90AB1 | Chaperone Mediated Autophagy |
| KEGG:04151 | 0.00118089914293 | 0.75 | HSP90AA1 CDC37 HSP90AB1 | PI3K-Akt signaling pathway |
| REAC:R-HSA-399954 | 0.00120515287053 | 0.5 | HSP90AA1 HSP90AB1 | Sema3A PAK dependent Axon repulsion |
| WP:WP2873 | 0.00124082421052 | 0.5 | HSP90AA1 CDC37 | Aryl Hydrocarbon Receptor Pathway |
| REAC:R-HSA-1236382 | 0.00136571756437 | 0.5 | HSP90AA1 CDC37 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| REAC:R-HSA-5637815 | 0.00136571756437 | 0.5 | HSP90AA1 CDC37 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| WP:WP2586 | 0.00144137960059 | 0.5 | HSP90AA1 CDC37 | Aryl Hydrocarbon Receptor |
| REAC:R-HSA-1643713 | 0.00171688133139 | 0.5 | HSP90AA1 CDC37 | Signaling by EGFR in Cancer |
| REAC:R-HSA-5339562 | 0.00210807296175 | 0.5 | HSP90AA1 HSP90AB1 | Uptake and actions of bacterial toxins |
| REAC:R-HSA-8863795 | 0.00253927088831 | 0.5 | HSP90AA1 CDC37 | Downregulation of ERBB2 signaling |
| REAC:R-HSA-3371571 | 0.00253927088831 | 0.5 | HSP90AA1 HSP90AB1 | HSF1-dependent transactivation |
| GO:1990565 | 0.00270494046827 | 0.5 | HSP90AB1 CDC37 | HSP90-CDC37 chaperone complex |
| KEGG:04612 | 0.00285390492132 | 0.5 | HSP90AA1 HSP90AB1 | Antigen processing and presentation |
| KEGG:04657 | 0.00480942745524 | 0.5 | HSP90AA1 HSP90AB1 | IL-17 signaling pathway |
| WP:WP231 | 0.0063819591539 | 0.5 | HSP90AA1 CDC37 | TNF alpha Signaling Pathway |
| KEGG:04914 | 0.00644602944709 | 0.5 | HSP90AA1 HSP90AB1 | Progesterone-mediated oocyte maturation |
| KEGG:04659 | 0.00726841321698 | 0.5 | HSP90AA1 HSP90AB1 | Th17 cell differentiation |
| KEGG:05215 | 0.00796156937098 | 0.5 | HSP90AA1 HSP90AB1 | Prostate cancer |
| REAC:R-HSA-1227986 | 0.00862684444961 | 0.5 | HSP90AA1 CDC37 | Signaling by ERBB2 |
| WP:WP2884 | 0.0101571058973 | 0.5 | HSP90AA1 HSP90AB1 | NRF2 pathway |
| REAC:R-HSA-3371497 | 0.013274030298 | 0.5 | HSP90AA1 HSP90AB1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| KEGG:04915 | 0.0146305942314 | 0.5 | HSP90AA1 HSP90AB1 | Estrogen signaling pathway |
| KEGG:05418 | 0.0153578793248 | 0.5 | HSP90AA1 HSP90AB1 | Fluid shear stress and atherosclerosis |
| REAC:R-HSA-373755 | 0.017117349746 | 0.5 | HSP90AA1 HSP90AB1 | Semaphorin interactions |
| REAC:R-HSA-2029482 | 0.017117349746 | 0.5 | HSP90AA1 HSP90AB1 | Regulation of actin dynamics for phagocytic cup formation |
| KEGG:04217 | 0.0226863463099 | 0.5 | HSP90AA1 HSP90AB1 | Necroptosis |
| KEGG:04141 | 0.0241976216174 | 0.5 | HSP90AA1 HSP90AB1 | Protein processing in endoplasmic reticulum |
| KEGG:04621 | 0.0245056398731 | 0.5 | HSP90AA1 HSP90AB1 | NOD-like receptor signaling pathway |
| CORUM:6402 | 0.0249595281251 | 0.25 | HSP90AA1 | NMNAT2-HSP90 complex |
| GO:0030911 | 0.0270421395626 | 0.5 | HSP90AA1 HSP90AB1 | TPR domain binding |
| REAC:R-HSA-8852276 | 0.0284687652941 | 0.5 | HSP90AA1 HSP90AB1 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-2029480 | 0.0315540312145 | 0.5 | HSP90AA1 HSP90AB1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-3371556 | 0.0356320611636 | 0.5 | HSP90AA1 HSP90AB1 | Cellular response to heat stress |
| GO:0044294 | 0.0405595771497 | 0.5 | HSP90AA1 HSP90AB1 | dendritic growth cone |
| GO:1902949 | 0.0405595771497 | 0.5 | HSP90AA1 HSP90AB1 | positive regulation of tau-protein kinase activity |
| GO:0030235 | 0.0405595771497 | 0.5 | HSP90AA1 HSP90AB1 | nitric-oxide synthase regulator activity |
| GO:1905323 | 0.0405595771497 | 0.5 | HSP90AA1 HSP90AB1 | telomerase holoenzyme complex assembly |
| CORUM:6706 | 0.0499140284799 | 0.25 | HSP90AB1 | CAPN1-HSP90AB1 complex |
| CORUM:4158 | 0.0499140284799 | 0.25 | HSP90AA1 | HSP90-FKBP38-CAM-Ca(2+) complex |
| CORUM:5716 | 0.0499140284799 | 0.25 | HSP90AA1 | NOS3-HSP90 complex, VEGF induced |
| CORUM:6591 | 0.0499140284799 | 0.25 | HSP90AA1 | Hsp90-p23 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HSP90AA1 | HSP90AB1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (HSP90AA1) Malo fraction boldt_WMM treiber_WMM |
| CDC37 | HSP90AA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (CDC37,HSP90AA1) gupta_WMM fraction boldt_WMM treiber_WMM |
| CDC37 | HSP90AB1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt hein (CDC37) fraction boldt_WMM treiber_WMM |
| FBL | HSP90AA1 | 0.988 | 0.901 | bioplex (FBL) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| FBL | HSP90AB1 | 0.985 | 0.9 | bioplex (FBL) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| CDC37 | FBL | 0.0 | 0.008 | bioplex (FBL) bioplex_WMM gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_06797 has an average edge precision of 0.776 which is ranked 1013 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSP90AA1 | HuMAP2_04367 HuMAP2_05213 HuMAP2_06797 |
| HSP90AB1 | HuMAP2_04367 HuMAP2_04784 HuMAP2_05213 HuMAP2_06797 |
| FBL | HuMAP2_00762 HuMAP2_02929 HuMAP2_03778 HuMAP2_04502 HuMAP2_06797 |
| CDC37 | HuMAP2_00324 HuMAP2_06797 |