hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06801
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS51 | Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog) | UniProt NCBI |
| VPS50 | Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50) | UniProt NCBI |
| VPS53 | Vacuolar protein sorting-associated protein 53 homolog | UniProt NCBI |
| VPS52 | Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein) | UniProt NCBI |
| VPS54 | Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p) | UniProt NCBI |
| EIPR1 | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000938 | 4.91515675326e-14 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | GARP complex |
| GO:1990745 | 4.91515675326e-14 | 0.833333333333 | VPS50 VPS51 VPS53 EIPR1 VPS52 | EARP complex |
| CORUM:6459 | 4.54011687692e-13 | 0.666666666667 | VPS50 VPS51 VPS53 VPS52 | EARP complex |
| CORUM:6463 | 4.54011687692e-13 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | GARP complex |
| GO:0032456 | 3.22787683477e-08 | 0.833333333333 | VPS50 VPS51 VPS53 EIPR1 VPS52 | endocytic recycling |
| GO:0099023 | 1.87214020073e-07 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | vesicle tethering complex |
| REAC:R-HSA-6811440 | 2.13011432628e-07 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | Retrograde transport at the Trans-Golgi-Network |
| GO:0016197 | 2.72047361196e-07 | 1.0 | VPS53 VPS54 VPS50 VPS52 VPS51 EIPR1 | endosomal transport |
| GO:0042147 | 1.2539847452e-06 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | retrograde transport, endosome to Golgi |
| GO:0055037 | 8.91963065123e-06 | 0.833333333333 | VPS50 VPS51 VPS53 EIPR1 VPS52 | recycling endosome |
| GO:0016482 | 2.26451406257e-05 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | cytosolic transport |
| REAC:R-HSA-6811442 | 7.1515078203e-05 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0005802 | 0.000111336965423 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | trans-Golgi network |
| GO:0098791 | 0.000265948528028 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | Golgi subcompartment |
| GO:0031984 | 0.00040236464741 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | organelle subcompartment |
| GO:0032588 | 0.000634686599476 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | trans-Golgi network membrane |
| GO:0007041 | 0.00084563217517 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | lysosomal transport |
| GO:0044440 | 0.00118995382955 | 0.833333333333 | VPS50 VPS51 VPS53 EIPR1 VPS52 | endosomal part |
| GO:0007034 | 0.00224645012257 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | vacuolar transport |
| REAC:R-HSA-199991 | 0.00529378407845 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | Membrane Trafficking |
| GO:0044433 | 0.00578472598372 | 1.0 | VPS53 VPS54 VPS50 VPS52 VPS51 EIPR1 | cytoplasmic vesicle part |
| REAC:R-HSA-5653656 | 0.00654030934977 | 0.666666666667 | VPS51 VPS54 VPS53 VPS52 | Vesicle-mediated transport |
| GO:0044431 | 0.0302793674882 | 0.833333333333 | EIPR1 VPS51 VPS54 VPS53 VPS52 | Golgi apparatus part |
| GO:0005768 | 0.0326105521072 | 0.833333333333 | VPS50 VPS51 VPS53 EIPR1 VPS52 | endosome |
| GO:0046907 | 0.038148924612 | 1.0 | VPS53 VPS54 VPS50 VPS52 VPS51 EIPR1 | intracellular transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS53 | VPS50 | 1.0 | 0.949 | hein_WMM bioplex (VPS50,VPS53) bioplex_WMM boldt youn_WMM hein (VPS50) Malo fraction boldt_WMM |
| VPS50 | EIPR1 | 1.0 | 0.949 | hein_WMM bioplex (EIPR1,VPS50) bioplex_WMM boldt hein (VPS50) boldt_WMM |
| VPS50 | VPS51 | 1.0 | 0.949 | hein_WMM bioplex (VPS50) bioplex_WMM boldt youn_WMM hein (VPS50) Malo fraction boldt_WMM |
| VPS53 | EIPR1 | 0.999 | 0.949 | hein_WMM bioplex (EIPR1) bioplex_WMM boldt fraction boldt_WMM |
| EIPR1 | VPS51 | 0.993 | 0.918 | hein_WMM bioplex (EIPR1) bioplex_WMM boldt fraction boldt_WMM |
| VPS52 | VPS50 | 0.968 | 0.88 | hein_WMM bioplex (VPS50) bioplex_WMM youn_WMM hein (VPS50) |
| VPS54 | EIPR1 | 0.941 | 0.853 | bioplex (EIPR1) bioplex_WMM |
| VPS52 | EIPR1 | 0.87 | 0.804 | hein_WMM bioplex (EIPR1) bioplex_WMM boldt boldt_WMM |
| VPS53 | VPS54 | 0.333 | 0.525 | bioplex (VPS53) bioplex_WMM |
| VPS54 | VPS50 | 0.192 | 0.445 | bioplex (VPS50) bioplex_WMM gupta_WMM |
| VPS52 | VPS51 | 0.013 | 0.143 | hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM |
| VPS53 | VPS52 | 0.012 | 0.153 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| VPS54 | VPS51 | 0.009 | 0.109 | bioplex_WMM youn_WMM WMM_only |
| VPS52 | VPS54 | 0.009 | 0.103 | bioplex_WMM WMM_only |
| VPS53 | VPS51 | 0.0 | 0.003 | hein_WMM bioplex_WMM boldt youn_WMM Malo fraction boldt_WMM |
Images
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Complex HuMAP2_06801 has an average edge precision of 0.582 which is ranked 2022 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| VPS51 | HuMAP2_00238 HuMAP2_04347 HuMAP2_05477 HuMAP2_06405 HuMAP2_06801 |
| VPS50 | HuMAP2_00238 HuMAP2_05477 HuMAP2_06405 HuMAP2_06801 |
| VPS53 | HuMAP2_00238 HuMAP2_05477 HuMAP2_06405 HuMAP2_06801 |
| VPS52 | HuMAP2_00238 HuMAP2_01625 HuMAP2_05477 HuMAP2_06405 HuMAP2_06801 |
| VPS54 | HuMAP2_00238 HuMAP2_05477 HuMAP2_06405 HuMAP2_06801 |
| EIPR1 | HuMAP2_00238 HuMAP2_05477 HuMAP2_06405 HuMAP2_06801 |