hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06811
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NCOA7 | Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1) | UniProt NCBI |
| ATP6V1E2 | V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2) | UniProt NCBI |
| ATP6V1G2 | V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2) | UniProt NCBI |
| ATP6V1B1 | V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 6.18225991007e-07 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Collecting duct acid secretion |
| REAC:R-HSA-77387 | 2.73044427427e-06 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Insulin receptor recycling |
| KEGG:05110 | 4.64366792489e-06 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Vibrio cholerae infection |
| REAC:R-HSA-917977 | 4.92812658075e-06 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Transferrin endocytosis and recycling |
| REAC:R-HSA-1222556 | 6.68850838342e-06 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | ROS and RNS production in phagocytes |
| KEGG:05323 | 7.43932072019e-06 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Rheumatoid arthritis |
| KEGG:05120 | 9.65633286465e-06 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04721 | 1.28493032652e-05 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Synaptic vesicle cycle |
| REAC:R-HSA-917937 | 3.34108196159e-05 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Iron uptake and transport |
| REAC:R-HSA-74752 | 4.37783464274e-05 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Signaling by Insulin receptor |
| KEGG:00190 | 7.14089641582e-05 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Oxidative phosphorylation |
| KEGG:04145 | 0.000107187194263 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Phagosome |
| KEGG:04150 | 0.00013020910184 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | mTOR signaling pathway |
| REAC:R-HSA-983712 | 0.000897547675762 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Ion channel transport |
| GO:0090383 | 0.00106129291317 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | phagosome acidification |
| KEGG:05165 | 0.00132804938561 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Human papillomavirus infection |
| GO:0033572 | 0.00197902980402 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | transferrin transport |
| GO:0090382 | 0.0025894674696 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | phagosome maturation |
| GO:0051452 | 0.00386509246613 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | intracellular pH reduction |
| GO:0045851 | 0.00416219722544 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | pH reduction |
| GO:0006826 | 0.00950554068334 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | iron ion transport |
| REAC:R-HSA-9006934 | 0.0147563350021 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Signaling by Receptor Tyrosine Kinases |
| GO:0051453 | 0.017346559408 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of intracellular pH |
| GO:0030641 | 0.0189701239271 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of cellular pH |
| GO:0006885 | 0.0215903857674 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | regulation of pH |
| GO:0030004 | 0.0308728000114 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | cellular monovalent inorganic cation homeostasis |
| GO:0000041 | 0.0344730150111 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | transition metal ion transport |
| REAC:R-HSA-382551 | 0.047385920536 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | Transport of small molecules |
| GO:0008286 | 0.0484715579516 | 0.75 | ATP6V1E2 ATP6V1G2 ATP6V1B1 | insulin receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6V1B1 | ATP6V1E2 | 1.0 | 0.949 | bioplex (ATP6V1B1) bioplex_WMM |
| ATP6V1B1 | NCOA7 | 0.18 | 0.437 | bioplex (ATP6V1B1) bioplex_WMM youn_WMM |
| ATP6V1B1 | ATP6V1G2 | 0.084 | 0.349 | bioplex (ATP6V1B1) bioplex_WMM |
| ATP6V1G2 | ATP6V1E2 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| ATP6V1E2 | NCOA7 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| ATP6V1G2 | NCOA7 | 0.009 | 0.095 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06811 has an average edge precision of 0.346 which is ranked 4044 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NCOA7 | HuMAP2_05404 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1E2 | HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1G2 | HuMAP2_00898 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |
| ATP6V1B1 | HuMAP2_00898 HuMAP2_03123 HuMAP2_05404 HuMAP2_05625 HuMAP2_06811 HuMAP2_06925 |