hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06816
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | UniProt NCBI |
| IDH3B | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta) | UniProt NCBI |
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6949 | 2.25356268047e-10 | 1.0 | IDH3G IDH3A IDH3B | Isocitrate dehydrogenase [NAD], mitochondrial |
| KEGG:01210 | 2.04492157933e-08 | 1.0 | IDH3G IDH3A IDH3B | 2-Oxocarboxylic acid metabolism |
| WP:WP78 | 4.37990295714e-08 | 1.0 | IDH3G IDH3A IDH3B | TCA Cycle (aka Krebs or citric acid cycle) |
| GO:0004449 | 9.08185760231e-08 | 1.0 | IDH3G IDH3A IDH3B | isocitrate dehydrogenase (NAD+) activity |
| KEGG:00020 | 1.09884462513e-07 | 1.0 | IDH3G IDH3A IDH3B | Citrate cycle (TCA cycle) |
| REAC:R-HSA-71403 | 5.97963891637e-07 | 1.0 | IDH3G IDH3A IDH3B | Citric acid cycle (TCA cycle) |
| GO:0004448 | 9.08185760231e-07 | 1.0 | IDH3G IDH3A IDH3B | isocitrate dehydrogenase activity |
| GO:0006102 | 9.08185760231e-07 | 1.0 | IDH3G IDH3A IDH3B | isocitrate metabolic process |
| KEGG:01230 | 1.7187866598e-06 | 1.0 | IDH3G IDH3A IDH3B | Biosynthesis of amino acids |
| KEGG:01200 | 7.23132386252e-06 | 1.0 | IDH3G IDH3A IDH3B | Carbon metabolism |
| REAC:R-HSA-71406 | 9.93609173322e-06 | 1.0 | IDH3G IDH3A IDH3B | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0072350 | 1.99800867251e-05 | 1.0 | IDH3G IDH3A IDH3B | tricarboxylic acid metabolic process |
| REAC:R-HSA-1428517 | 0.000330512177188 | 1.0 | IDH3G IDH3A IDH3B | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006099 | 0.000368723418654 | 1.0 | IDH3G IDH3A IDH3B | tricarboxylic acid cycle |
| GO:0009060 | 0.00541641987402 | 1.0 | IDH3G IDH3A IDH3B | aerobic respiration |
| KEGG:01100 | 0.0105851300972 | 1.0 | IDH3G IDH3A IDH3B | Metabolic pathways |
| GO:0016616 | 0.0151349156943 | 1.0 | IDH3G IDH3A IDH3B | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:1902652 | 0.0151349156943 | 1.0 | IDH3G IDH3A IDH3B | secondary alcohol metabolic process |
| GO:0016614 | 0.0185411572066 | 1.0 | IDH3G IDH3A IDH3B | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0045333 | 0.0442598881134 | 1.0 | IDH3G IDH3A IDH3B | cellular respiration |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IDH3G | IDH3A | 0.999 | 0.948 | bioplex (IDH3A,IDH3G) bioplex_WMM Guru fraction |
| IDH3G | IDH3B | 0.975 | 0.887 | bioplex (IDH3B,IDH3G) bioplex_WMM Guru gupta_WMM fraction |
| IDH3A | IDH3B | 0.97 | 0.881 | bioplex (IDH3A,IDH3B) bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_06816 has an average edge precision of 0.905 which is ranked 529 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IDH3G | HuMAP2_00244 HuMAP2_04107 HuMAP2_05860 HuMAP2_06816 |
| IDH3B | HuMAP2_04107 HuMAP2_06816 |
| IDH3A | HuMAP2_04107 HuMAP2_05860 HuMAP2_06816 |