hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06825
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IFT57 | Intraflagellar transport protein 57 homolog (Dermal papilla-derived protein 8) (Estrogen-related receptor beta-like protein 1) (HIP1-interacting protein) (MHS4R2) | UniProt NCBI |
| EHBP1 | EH domain-binding protein 1 | UniProt NCBI |
| HOMER1 | Homer protein homolog 1 (Homer-1) | UniProt NCBI |
| HOMER3 | Homer protein homolog 3 (Homer-3) | UniProt NCBI |
| HOMER2 | Homer protein homolog 2 (Homer-2) (Cupidin) | UniProt NCBI |
| SPAG5 | Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035256 | 1.81582264982e-05 | 0.5 | HOMER1 HOMER3 HOMER2 | G protein-coupled glutamate receptor binding |
| GO:2001256 | 0.000101639975642 | 0.5 | HOMER1 HOMER3 HOMER2 | regulation of store-operated calcium entry |
| REAC:R-HSA-6794361 | 0.00013845803743 | 0.5 | HOMER1 HOMER3 HOMER2 | Neurexins and neuroligins |
| KEGG:04724 | 0.000267985848775 | 0.5 | HOMER1 HOMER3 HOMER2 | Glutamatergic synapse |
| KEGG:04068 | 0.000397675631396 | 0.5 | HOMER1 HOMER3 HOMER2 | FoxO signaling pathway |
| REAC:R-HSA-6794362 | 0.000502143964773 | 0.5 | HOMER1 HOMER3 HOMER2 | Protein-protein interactions at synapses |
| GO:0007216 | 0.000518697707158 | 0.5 | HOMER1 HOMER3 HOMER2 | G protein-coupled glutamate receptor signaling pathway |
| GO:0002115 | 0.000660060925697 | 0.5 | HOMER1 HOMER3 HOMER2 | store-operated calcium entry |
| GO:0035254 | 0.000824951429902 | 0.5 | HOMER1 HOMER3 HOMER2 | glutamate receptor binding |
| REAC:R-HSA-112316 | 0.0370544697669 | 0.5 | HOMER1 HOMER3 HOMER2 | Neuronal System |
| CORUM:74 | 0.0499726005494 | 0.166666666667 | HOMER3 | HOMER3-IP3R-TRPC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HOMER2 | HOMER1 | 1.0 | 0.949 | bioplex (HOMER1) bioplex_WMM |
| HOMER3 | HOMER1 | 1.0 | 0.949 | hein_WMM bioplex (HOMER1,HOMER3) bioplex_WMM hein (HOMER1) |
| HOMER3 | HOMER2 | 0.929 | 0.845 | bioplex (HOMER3) bioplex_WMM |
| HOMER1 | IFT57 | 0.272 | 0.484 | bioplex (IFT57) bioplex_WMM boldt (IFT57) boldt_WMM |
| IFT57 | EHBP1 | 0.202 | 0.451 | bioplex (IFT57) bioplex_WMM boldt (IFT57) youn_WMM gupta_WMM boldt_WMM |
| HOMER2 | IFT57 | 0.129 | 0.399 | bioplex (IFT57) bioplex_WMM |
| SPAG5 | IFT57 | 0.103 | 0.365 | bioplex (IFT57) bioplex_WMM youn_WMM gupta_WMM |
| HOMER2 | EHBP1 | 0.009 | 0.091 | bioplex_WMM WMM_only |
| SPAG5 | EHBP1 | 0.008 | 0.09 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| HOMER1 | EHBP1 | 0.008 | 0.059 | bioplex_WMM boldt boldt_WMM |
| HOMER3 | EHBP1 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| SPAG5 | HOMER2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| SPAG5 | HOMER1 | 0.007 | 0.005 | hein_WMM bioplex_WMM WMM_only |
| SPAG5 | HOMER3 | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| HOMER3 | IFT57 | 0.004 | 0.011 | bioplex (IFT57) bioplex_WMM |
Images
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Complex HuMAP2_06825 has an average edge precision of 0.314 which is ranked 4416 out of all 6965 complexes.
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