hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06828
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CSNK2B | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | UniProt NCBI |
| CSNK2A1 | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | UniProt NCBI |
| CSNK2A2 | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2720 | 2.25356268047e-10 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:5224 | 2.25356268047e-10 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:2719 | 9.0142507219e-10 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Casein kinase II-HMG1 complex |
| CORUM:938 | 2.25356268047e-09 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | FACT complex, UV-activated |
| REAC:R-HSA-201688 | 2.51774270163e-08 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | WNT mediated activation of DVL |
| REAC:R-HSA-8934903 | 3.77661405245e-08 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Receptor Mediated Mitophagy |
| REAC:R-HSA-2514853 | 7.41834903159e-08 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Condensation of Prometaphase Chromosomes |
| REAC:R-HSA-445144 | 5.12540478546e-07 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Signal transduction by L1 |
| REAC:R-HSA-5205647 | 9.09984147875e-07 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Mitophagy |
| KEGG:04137 | 1.13733726662e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Mitophagy - animal |
| REAC:R-HSA-1483191 | 1.16895196861e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Synthesis of PC |
| KEGG:04520 | 1.57561207687e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Adherens junction |
| KEGG:03008 | 2.19979431659e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Ribosome biogenesis in eukaryotes |
| KEGG:04064 | 2.37809343488e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | NF-kappa B signaling pathway |
| KEGG:05235 | 2.47074642585e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| REAC:R-HSA-8939243 | 3.21012194458e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| CORUM:5225 | 3.35600554376e-06 | 0.666666666667 | CSNK2A1 CSNK2B | Casein kinase II (beta-dimer, alpha-dimer) |
| CORUM:5223 | 3.35600554376e-06 | 0.666666666667 | CSNK2A2 CSNK2B | Casein kinase II (beta-dimer, alpha'-dimer) |
| REAC:R-HSA-6814122 | 4.10886616968e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| WP:WP4336 | 4.90008084364e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 6.82717373445e-06 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:05162 | 1.02659874862e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Measles |
| WP:WP428 | 1.27844858595e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Wnt Signaling |
| KEGG:04310 | 1.55974889844e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Wnt signaling pathway |
| REAC:R-HSA-8948751 | 2.2531998792e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Regulation of PTEN stability and activity |
| WP:WP4262 | 2.82110193573e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Breast cancer pathway |
| REAC:R-HSA-1632852 | 4.7655024582e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Macroautophagy |
| REAC:R-HSA-390466 | 5.28186451049e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Chaperonin-mediated protein folding |
| REAC:R-HSA-6804756 | 5.46192807335e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-391251 | 6.42384066445e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Protein folding |
| REAC:R-HSA-9612973 | 7.95116633082e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Autophagy |
| REAC:R-HSA-1483206 | 8.92382428809e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Glycerophospholipid biosynthesis |
| REAC:R-HSA-373760 | 9.97273388147e-05 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | L1CAM interactions |
| REAC:R-HSA-6807070 | 0.000180286113329 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | PTEN Regulation |
| REAC:R-HSA-5633007 | 0.000284464461562 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Regulation of TP53 Activity |
| GO:0006656 | 0.000368723418654 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | phosphatidylcholine biosynthetic process |
| REAC:R-HSA-1483257 | 0.00045921109135 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Phospholipid metabolism |
| REAC:R-HSA-68877 | 0.000513949964862 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Mitotic Prometaphase |
| REAC:R-HSA-8878171 | 0.000776305048729 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-201681 | 0.000808797867084 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1257604 | 0.000842184933696 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.00134762672661 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Intracellular signaling by second messengers |
| GO:0031519 | 0.00137862598403 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | PcG protein complex |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Signaling by WNT |
| GO:0046470 | 0.00238262534197 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | phosphatidylcholine metabolic process |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-68886 | 0.00398320383305 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | M Phase |
| GO:0005956 | 0.00405722906526 | 0.666666666667 | CSNK2A1 CSNK2B | protein kinase CK2 complex |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Cellular responses to external stimuli |
| REAC:R-HSA-422475 | 0.0100572742862 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Axon guidance |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Cell Cycle, Mitotic |
| GO:0018107 | 0.0125706532002 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | peptidyl-threonine phosphorylation |
| GO:0018210 | 0.0160613559883 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | peptidyl-threonine modification |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Cell Cycle |
| REAC:R-HSA-556833 | 0.0194595609558 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | Metabolism of lipids |
| GO:0097164 | 0.0372392489125 | 1.0 | CSNK2A1 CSNK2B CSNK2A2 | ammonium ion metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK2A2 | CSNK2A1 | 1.0 | 0.949 | hein_WMM bioplex (CSNK2A2) bioplex_WMM boldt youn_WMM hein (CSNK2A2) Malo gupta_WMM fraction boldt_WMM |
| CSNK2A1 | CSNK2B | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CSNK2A2 | CSNK2B | 0.994 | 0.923 | hein_WMM bioplex_WMM boldt youn_WMM hein (CSNK2A2) gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_06828 has an average edge precision of 0.94 which is ranked 395 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CSNK2B | HuMAP2_01251 HuMAP2_05042 HuMAP2_05669 HuMAP2_06657 HuMAP2_06828 |
| CSNK2A1 | HuMAP2_01251 HuMAP2_05042 HuMAP2_05669 HuMAP2_06657 HuMAP2_06828 |
| CSNK2A2 | HuMAP2_00169 HuMAP2_00633 HuMAP2_05042 HuMAP2_05669 HuMAP2_05740 HuMAP2_06272 HuMAP2_06657 HuMAP2_06828 |