hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06831
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CNOT1 | CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1) | UniProt NCBI |
| CNOT3 | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2) | UniProt NCBI |
| CNOT9 | CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1) | UniProt NCBI |
| CNOT7 | CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6765 | 5.7134586066e-12 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | CCR4-NOT complex |
| CORUM:7192 | 5.7134586066e-12 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | CCR4-NOT-CNOT7-CNOT6 complex |
| CORUM:7214 | 5.7134586066e-12 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | CCR4-NOT-CNOT7-CNOT6L complex |
| GO:0030015 | 3.6593342028e-10 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | CCR4-NOT core complex |
| REAC:R-HSA-6804115 | 4.39392173793e-10 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| REAC:R-HSA-429947 | 1.14722621228e-09 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | Deadenylation of mRNA |
| REAC:R-HSA-6791312 | 1.76464250107e-08 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | TP53 Regulates Transcription of Cell Cycle Genes |
| KEGG:03018 | 2.31843669078e-08 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | RNA degradation |
| REAC:R-HSA-429914 | 3.33094636765e-08 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | Deadenylation-dependent mRNA decay |
| GO:0030014 | 4.43999216606e-08 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | CCR4-NOT complex |
| CORUM:7216 | 5.67022676981e-08 | 0.75 | CNOT1 CNOT9 CNOT3 | CCR4-NOT-CNOT8-CNOT6L complex |
| CORUM:7215 | 5.67022676981e-08 | 0.75 | CNOT1 CNOT9 CNOT3 | CCR4-NOT-CNOT8-CNOT6 complex |
| GO:0000289 | 8.77264386218e-07 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | nuclear-transcribed mRNA poly(A) tail shortening |
| GO:0006977 | 7.71512067313e-06 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| GO:0072431 | 8.3202281769e-06 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction involved in mitotic G1 DNA damage checkpoint |
| GO:1902400 | 8.3202281769e-06 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | intracellular signal transduction involved in G1 DNA damage checkpoint |
| GO:0072413 | 8.96024572897e-06 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction involved in mitotic cell cycle checkpoint |
| GO:1902403 | 8.96024572897e-06 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction involved in mitotic DNA integrity checkpoint |
| GO:1902402 | 8.96024572897e-06 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction involved in mitotic DNA damage checkpoint |
| GO:0044819 | 1.18961295599e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | mitotic G1/S transition checkpoint |
| GO:0031571 | 1.18961295599e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | mitotic G1 DNA damage checkpoint |
| GO:0044783 | 1.27309456693e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | G1 DNA damage checkpoint |
| CORUM:6394 | 1.50819606993e-05 | 0.5 | CNOT1 CNOT3 | CNOT1-CNOT2-CNOT3 complex |
| GO:0000932 | 1.65167708578e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | P-body |
| GO:0072401 | 2.10899871844e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction involved in DNA integrity checkpoint |
| GO:0072422 | 2.10899871844e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction involved in DNA damage checkpoint |
| GO:0000288 | 2.23681682258e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:0072395 | 2.23681682258e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction involved in cell cycle checkpoint |
| GO:0071158 | 2.65528608423e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | positive regulation of cell cycle arrest |
| GO:2000134 | 5.43019580356e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of G1/S transition of mitotic cell cycle |
| REAC:R-HSA-3700989 | 5.4469226338e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | Transcriptional Regulation by TP53 |
| GO:0044773 | 5.68877655611e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | mitotic DNA damage checkpoint |
| GO:1902807 | 5.68877655611e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of cell cycle G1/S phase transition |
| GO:0071156 | 7.43942887385e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | regulation of cell cycle arrest |
| GO:0030330 | 7.43942887385e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | DNA damage response, signal transduction by p53 class mediator |
| GO:0044774 | 8.45267167948e-05 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | mitotic DNA integrity checkpoint |
| GO:0017148 | 0.000107859485517 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of translation |
| GO:0034249 | 0.000168654810117 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of cellular amide metabolic process |
| GO:0042770 | 0.000180861495173 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction in response to DNA damage |
| GO:2000045 | 0.000193719078201 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | regulation of G1/S transition of mitotic cell cycle |
| GO:0000077 | 0.000260251848503 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | DNA damage checkpoint |
| GO:1902806 | 0.00027710625393 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | regulation of cell cycle G1/S phase transition |
| GO:0031570 | 0.000373974563235 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | DNA integrity checkpoint |
| GO:0007093 | 0.000468165581659 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | mitotic cell cycle checkpoint |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | Metabolism of RNA |
| GO:0036464 | 0.00110299395387 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | cytoplasmic ribonucleoprotein granule |
| GO:0000075 | 0.00125624335733 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | cell cycle checkpoint |
| GO:0007050 | 0.00125624335733 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | cell cycle arrest |
| GO:0035770 | 0.00136692623874 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | ribonucleoprotein granule |
| GO:0000956 | 0.00148476668027 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | nuclear-transcribed mRNA catabolic process |
| GO:1901991 | 0.00151538042626 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of mitotic cell cycle phase transition |
| GO:0000082 | 0.00161006679656 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | G1/S transition of mitotic cell cycle |
| GO:1901988 | 0.00195799214531 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of cell cycle phase transition |
| GO:0090068 | 0.00199564584041 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | positive regulation of cell cycle process |
| GO:0044843 | 0.00203384001918 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | cell cycle G1/S phase transition |
| GO:0072331 | 0.00281974424791 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | signal transduction by p53 class mediator |
| GO:0006417 | 0.00393880365476 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | regulation of translation |
| REAC:R-HSA-212436 | 0.00429443977897 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | Generic Transcription Pathway |
| GO:0045787 | 0.00505059184256 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | positive regulation of cell cycle |
| GO:0045930 | 0.00512711596139 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of mitotic cell cycle |
| REAC:R-HSA-73857 | 0.00664358115488 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | RNA Polymerase II Transcription |
| GO:0010948 | 0.00665909549353 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | negative regulation of cell cycle process |
| GO:0034248 | 0.00754257074571 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | regulation of cellular amide metabolic process |
| REAC:R-HSA-74160 | 0.0102868657133 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | Gene expression (Transcription) |
| GO:0006402 | 0.0128783441389 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | mRNA catabolic process |
| GO:1901990 | 0.0146522218849 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | regulation of mitotic cell cycle phase transition |
| GO:0006401 | 0.0181401540934 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | RNA catabolic process |
| GO:1901987 | 0.0193609640933 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | regulation of cell cycle phase transition |
| WP:WP4352 | 0.0368740288317 | 0.5 | CNOT1 CNOT9 | Ciliary landscape |
| GO:0034655 | 0.0445306239544 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | nucleobase-containing compound catabolic process |
| GO:0044772 | 0.0485535587519 | 1.0 | CNOT1 CNOT3 CNOT7 CNOT9 | mitotic cell cycle phase transition |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CNOT9 | CNOT3 | 1.0 | 0.949 | hein_WMM youn (CNOT9) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CNOT9 | CNOT1 | 1.0 | 0.949 | hein_WMM youn (CNOT1,CNOT9) bioplex_WMM boldt youn_WMM hein (CNOT1) Malo gupta_WMM fraction boldt_WMM |
| CNOT7 | CNOT1 | 1.0 | 0.949 | hein_WMM youn (CNOT1,CNOT7) bioplex (CNOT7) bioplex_WMM Guru boldt youn_WMM hein (CNOT1) Malo gupta_WMM fraction boldt_WMM |
| CNOT7 | CNOT9 | 1.0 | 0.949 | hein_WMM youn (CNOT7,CNOT9) bioplex (CNOT7) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CNOT7 | CNOT3 | 1.0 | 0.949 | hein_WMM youn (CNOT7) bioplex (CNOT7) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CNOT3 | CNOT1 | 1.0 | 0.949 | hein_WMM youn (CNOT1) bioplex_WMM Guru boldt youn_WMM hein (CNOT1) Malo gupta_WMM fraction boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_06831 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CNOT1 | HuMAP2_00299 HuMAP2_01195 HuMAP2_01257 HuMAP2_06831 |
| CNOT3 | HuMAP2_00299 HuMAP2_01195 HuMAP2_01257 HuMAP2_06831 |
| CNOT9 | HuMAP2_00299 HuMAP2_01195 HuMAP2_01257 HuMAP2_06831 |
| CNOT7 | HuMAP2_00299 HuMAP2_01195 HuMAP2_01257 HuMAP2_06831 HuMAP2_06839 |