hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06832

Confidence: Medium

Genename	Protein Name	Links
CISD1	CDGSH iron-sulfur domain-containing protein 1 (MitoNEET)	UniProt NCBI
CISD2	CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1)	UniProt NCBI
TECR	Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER)	UniProt NCBI
TSPO	Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR)	UniProt NCBI
PGRMC2	Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6)	UniProt NCBI
VDAC1	Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)	UniProt NCBI
RER1	Protein RER1	UniProt NCBI
VDAC2	Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)	UniProt NCBI
DPM1	Dolichol-phosphate mannosyltransferase subunit 1 (EC 2.4.1.83) (Dolichol-phosphate mannose synthase subunit 1) (DPM synthase subunit 1) (Dolichyl-phosphate beta-D-mannosyltransferase subunit 1) (Mannose-P-dolichol synthase subunit 1) (MPD synthase subunit 1)	UniProt NCBI
VDAC3	Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04979	6.00318590186e-07	0.4	VDAC3 VDAC2 TSPO VDAC1	Cholesterol metabolism
REAC:R-HSA-8949215	8.0188642519e-05	0.3	VDAC3 VDAC1 VDAC2	Mitochondrial calcium ion transport
KEGG:05166	0.000281649520264	0.4	VDAC3 VDAC2 TSPO VDAC1	Human T-cell leukemia virus 1 infection
GO:0005741	0.000414093131115	0.5	VDAC1 VDAC2 CISD2 VDAC3 TSPO	mitochondrial outer membrane
GO:0031968	0.000616180535985	0.5	VDAC1 VDAC2 CISD2 VDAC3 TSPO	organelle outer membrane
GO:0019867	0.000640069781439	0.5	VDAC1 VDAC2 CISD2 VDAC3 TSPO	outer membrane
KEGG:05012	0.00326589651874	0.3	VDAC3 VDAC1 VDAC2	Parkinson disease
GO:0008308	0.00395159560419	0.3	VDAC3 VDAC1 VDAC2	voltage-gated anion channel activity
KEGG:04022	0.00456410896629	0.3	VDAC3 VDAC1 VDAC2	cGMP-PKG signaling pathway
KEGG:04218	0.00495958625926	0.3	VDAC3 VDAC1 VDAC2	Cellular senescence
KEGG:04217	0.00570445344424	0.3	VDAC3 VDAC1 VDAC2	Necroptosis
KEGG:04621	0.00639824026536	0.3	VDAC3 VDAC1 VDAC2	NOD-like receptor signaling pathway
KEGG:04020	0.00651897348671	0.3	VDAC3 VDAC1 VDAC2	Calcium signaling pathway
KEGG:05016	0.00880458858502	0.3	VDAC3 VDAC1 VDAC2	Huntington disease
KEGG:04216	0.0135375519613	0.2	VDAC2 VDAC3	Ferroptosis
WP:WP4313	0.0175768464916	0.2	VDAC2 VDAC3	Ferroptosis
REAC:R-HSA-5689880	0.0495300972407	0.3	VDAC3 VDAC1 VDAC2	Ub-specific processing proteases

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CISD1	VDAC1	0.331	0.522	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
CISD1	VDAC3	0.244	0.468	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
CISD1	VDAC2	0.109	0.376	bioplex_WMM Guru boldt fraction boldt_WMM
RER1	VDAC2	0.071	0.352	bioplex (RER1) bioplex_WMM Guru youn_WMM fraction boldt_WMM treiber_WMM
CISD2	VDAC2	0.05	0.298	bioplex_WMM Guru youn_WMM fraction treiber_WMM
TSPO	VDAC2	0.045	0.282	bioplex (TSPO) bioplex_WMM Guru boldt fraction boldt_WMM
VDAC3	CISD2	0.043	0.27	bioplex_WMM Guru gupta_WMM fraction
PGRMC2	VDAC2	0.039	0.265	bioplex_WMM boldt youn_WMM fraction boldt_WMM
VDAC3	TECR	0.025	0.217	bioplex (VDAC3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM
CISD1	DPM1	0.025	0.211	bioplex_WMM boldt fraction boldt_WMM
VDAC1	CISD2	0.025	0.21	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
CISD1	TECR	0.023	0.211	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM
VDAC3	VDAC2	0.022	0.209	hein_WMM bioplex (VDAC3) bioplex_WMM boldt boldt_WMM treiber_WMM
CISD2	TECR	0.022	0.199	bioplex_WMM Guru gupta_WMM fraction
VDAC1	TSPO	0.02	0.185	bioplex_WMM Guru boldt fraction boldt_WMM
VDAC1	VDAC3	0.019	0.184	hein_WMM bioplex (VDAC1,VDAC3) bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM
VDAC3	TSPO	0.013	0.143	bioplex_WMM Guru boldt fraction boldt_WMM
VDAC3	PGRMC2	0.01	0.131	bioplex_WMM boldt gupta_WMM fraction boldt_WMM
VDAC1	VDAC2	0.008	0.029	hein_WMM bioplex (VDAC1,VDAC2) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM
CISD1	CISD2	0.007	0.001	bioplex_WMM gupta_WMM WMM_only
TSPO	TECR	0.007	0.009	bioplex_WMM boldt boldt_WMM
DPM1	TSPO	0.007	0.004	bioplex_WMM boldt boldt_WMM
TSPO	PGRMC2	0.007	0.004	bioplex_WMM boldt boldt_WMM
RER1	TSPO	0.007	0.005	bioplex_WMM WMM_only
DPM1	CISD2	0.006	0.006	bioplex_WMM youn_WMM gupta_WMM WMM_only
CISD1	TSPO	0.006	0.005	bioplex_WMM Guru boldt fraction boldt_WMM
RER1	CISD2	0.006	0.009	bioplex_WMM Guru youn_WMM gupta_WMM fraction
CISD2	PGRMC2	0.006	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
RER1	TECR	0.006	0.004	bioplex_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM
CISD1	PGRMC2	0.006	0.008	bioplex_WMM boldt gupta_WMM boldt_WMM
VDAC1	DPM1	0.006	0.009	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
PGRMC2	TECR	0.006	0.01	bioplex_WMM boldt gupta_WMM boldt_WMM
DPM1	PGRMC2	0.005	0.008	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
DPM1	VDAC2	0.004	0.012	bioplex (VDAC2) bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
TECR	VDAC2	0.004	0.016	bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM
RER1	VDAC1	0.003	0.012	bioplex (RER1) bioplex_WMM youn_WMM gupta_WMM boldt_WMM treiber_WMM
RER1	PGRMC2	0.003	0.01	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
RER1	DPM1	0.003	0.013	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM
VDAC3	DPM1	0.003	0.018	bioplex (VDAC3) bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM
RER1	CISD1	0.003	0.014	bioplex_WMM gupta_WMM WMM_only boldt_WMM
VDAC1	TECR	0.003	0.018	bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM
RER1	VDAC3	0.0	0.016	bioplex_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM
DPM1	TECR	0.0	0.008	bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM
VDAC1	PGRMC2	0.0	0.013	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM

Images

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Complex HuMAP2_06832 has an average edge precision of 0.114 which is ranked 6896 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CISD1	HuMAP2_00435 HuMAP2_03081 HuMAP2_03276 HuMAP2_03991 HuMAP2_04228 HuMAP2_05480 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
CISD2	HuMAP2_00435 HuMAP2_00533 HuMAP2_02453 HuMAP2_02928 HuMAP2_03081 HuMAP2_03991 HuMAP2_05351 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
TECR	HuMAP2_01892 HuMAP2_03276 HuMAP2_04822 HuMAP2_05177 HuMAP2_05807 HuMAP2_06329 HuMAP2_06832
TSPO	HuMAP2_01359 HuMAP2_02453 HuMAP2_03081 HuMAP2_03970 HuMAP2_04186 HuMAP2_05588 HuMAP2_06033 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
PGRMC2	HuMAP2_01521 HuMAP2_03276 HuMAP2_06832 HuMAP2_06982
VDAC1	HuMAP2_00435 HuMAP2_01359 HuMAP2_02453 HuMAP2_03081 HuMAP2_04186 HuMAP2_05480 HuMAP2_06033 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
RER1	HuMAP2_00163 HuMAP2_02373 HuMAP2_03081 HuMAP2_03113 HuMAP2_03349 HuMAP2_03970 HuMAP2_05588 HuMAP2_06832
VDAC2	HuMAP2_03081 HuMAP2_03970 HuMAP2_03991 HuMAP2_04721 HuMAP2_04908 HuMAP2_05588 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832
DPM1	HuMAP2_00435 HuMAP2_03081 HuMAP2_03276 HuMAP2_04228 HuMAP2_06329 HuMAP2_06671 HuMAP2_06798 HuMAP2_06832
VDAC3	HuMAP2_00435 HuMAP2_02584 HuMAP2_03081 HuMAP2_03991 HuMAP2_04721 HuMAP2_04908 HuMAP2_05807 HuMAP2_06329 HuMAP2_06798 HuMAP2_06832

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06832