hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06844
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMAD9 | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | UniProt NCBI |
| ZFYVE9 | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | UniProt NCBI |
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | UniProt NCBI |
| SMAD3 | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | UniProt NCBI |
| LEMD3 | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1827 | 5.40532307664e-09 | 0.6 | SMAD3 ZFYVE9 SMAD2 | PML-SMAD2/3-SARA complex |
| WP:WP560 | 1.22392764803e-08 | 0.8 | SMAD3 SMAD2 SMAD9 ZFYVE9 | TGF-beta Receptor Signaling |
| KEGG:04350 | 1.65048029426e-07 | 0.8 | SMAD3 SMAD2 SMAD9 ZFYVE9 | TGF-beta signaling pathway |
| WP:WP4331 | 7.65599689843e-07 | 0.6 | SMAD3 SMAD9 SMAD2 | Neovascularisation processes |
| CORUM:6513 | 6.70868171695e-06 | 0.4 | LEMD3 SMAD2 | MAN1-SMAD2 complex |
| WP:WP4535 | 8.87288130353e-06 | 0.6 | SMAD3 SMAD2 LEMD3 | Envelope proteins and their potential roles in EDMD physiopathology |
| GO:0030618 | 9.08002798436e-06 | 0.6 | SMAD3 SMAD9 SMAD2 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| CORUM:2834 | 2.0123342217e-05 | 0.4 | SMAD3 SMAD2 | SMAD4-SMAD2-SMAD3 complex |
| CORUM:2830 | 2.0123342217e-05 | 0.4 | SMAD3 SMAD2 | TIF1gamma-SMAD2-SMAD3 complex |
| GO:0007178 | 2.72199042364e-05 | 1.0 | SMAD3 ZFYVE9 SMAD2 SMAD9 LEMD3 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| GO:0071141 | 3.17736949706e-05 | 0.6 | SMAD3 SMAD9 SMAD2 | SMAD protein complex |
| REAC:R-HSA-3315487 | 4.04876825444e-05 | 0.4 | SMAD3 SMAD2 | SMAD2/3 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3311021 | 4.04876825444e-05 | 0.4 | SMAD3 SMAD2 | SMAD4 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3304347 | 4.04876825444e-05 | 0.4 | SMAD3 SMAD2 | Loss of Function of SMAD4 in Cancer |
| GO:0005072 | 5.0832789986e-05 | 0.6 | SMAD3 SMAD9 SMAD2 | transforming growth factor beta receptor, cytoplasmic mediator activity |
| REAC:R-HSA-3304356 | 8.09644897083e-05 | 0.4 | SMAD3 SMAD2 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| REAC:R-HSA-3656532 | 8.09644897083e-05 | 0.4 | SMAD3 SMAD2 | TGFBR1 KD Mutants in Cancer |
| REAC:R-HSA-3304349 | 0.000134922692372 | 0.4 | SMAD3 SMAD2 | Loss of Function of SMAD2/3 in Cancer |
| REAC:R-HSA-3656534 | 0.000134922692372 | 0.4 | SMAD3 SMAD2 | Loss of Function of TGFBR1 in Cancer |
| REAC:R-HSA-3304351 | 0.000202356855584 | 0.4 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex in Cancer |
| WP:WP366 | 0.000206095076976 | 0.6 | SMAD3 ZFYVE9 SMAD2 | TGF-beta Signaling Pathway |
| KEGG:04550 | 0.000258594789588 | 0.6 | SMAD3 SMAD9 SMAD2 | Signaling pathways regulating pluripotency of stem cells |
| CORUM:2829 | 0.000301566439547 | 0.4 | SMAD3 SMAD2 | RSmad complex |
| REAC:R-HSA-9006936 | 0.000306125075711 | 0.6 | SMAD3 SMAD9 SMAD2 | Signaling by TGF-beta family members |
| WP:WP3859 | 0.000350028616523 | 0.4 | SMAD3 SMAD2 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| WP:WP3874 | 0.000350028616523 | 0.4 | SMAD3 SMAD2 | Canonical and Non-Canonical TGF-B signaling |
| REAC:R-HSA-1502540 | 0.000485460775426 | 0.4 | SMAD3 SMAD2 | Signaling by Activin |
| GO:0071363 | 0.000790881181884 | 1.0 | SMAD3 ZFYVE9 SMAD2 SMAD9 LEMD3 | cellular response to growth factor stimulus |
| GO:0070848 | 0.000946536802537 | 1.0 | SMAD3 ZFYVE9 SMAD2 SMAD9 LEMD3 | response to growth factor |
| WP:WP2870 | 0.000998738671819 | 0.4 | SMAD3 SMAD2 | Extracellular vesicle-mediated signaling in recipient cells |
| WP:WP3668 | 0.000998738671819 | 0.4 | SMAD3 SMAD2 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| WP:WP3850 | 0.00108182147376 | 0.4 | SMAD3 SMAD2 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| GO:0007179 | 0.001292590007 | 0.8 | SMAD3 SMAD2 ZFYVE9 LEMD3 | transforming growth factor beta receptor signaling pathway |
| REAC:R-HSA-1181150 | 0.00161668141155 | 0.4 | SMAD3 SMAD2 | Signaling by NODAL |
| KEGG:04144 | 0.00171388219445 | 0.6 | SMAD3 ZFYVE9 SMAD2 | Endocytosis |
| REAC:R-HSA-9617828 | 0.00183199274719 | 0.4 | SMAD3 SMAD2 | FOXO-mediated transcription of cell cycle genes |
| GO:0032924 | 0.00183428165932 | 0.6 | SMAD3 SMAD2 LEMD3 | activin receptor signaling pathway |
| GO:0071560 | 0.00265571901763 | 0.8 | SMAD3 SMAD2 ZFYVE9 LEMD3 | cellular response to transforming growth factor beta stimulus |
| REAC:R-HSA-2173788 | 0.00282729215335 | 0.4 | SMAD3 SMAD2 | Downregulation of TGF-beta receptor signaling |
| WP:WP1971 | 0.00299893680898 | 0.4 | SMAD3 SMAD2 | Integrated Cancer Pathway |
| GO:0071559 | 0.00302325172609 | 0.8 | SMAD3 SMAD2 ZFYVE9 LEMD3 | response to transforming growth factor beta |
| REAC:R-HSA-9615017 | 0.00340529843133 | 0.4 | SMAD3 SMAD2 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| REAC:R-HSA-2173795 | 0.00340529843133 | 0.4 | SMAD3 SMAD2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| KEGG:05321 | 0.00403884103568 | 0.4 | SMAD3 SMAD2 | Inflammatory bowel disease (IBD) |
| GO:0071144 | 0.00450823411379 | 0.4 | SMAD3 SMAD2 | heteromeric SMAD protein complex |
| REAC:R-HSA-2173789 | 0.00472180750517 | 0.4 | SMAD3 SMAD2 | TGF-beta receptor signaling activates SMADs |
| REAC:R-HSA-2173796 | 0.00625202329777 | 0.4 | SMAD3 SMAD2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| WP:WP2324 | 0.00688743357746 | 0.4 | SMAD3 SMAD2 | AGE/RAGE pathway |
| MIRNA:hsa-miR-145-5p | 0.00723695660188 | 0.6 | SMAD3 ZFYVE9 SMAD2 | hsa-miR-145-5p |
| WP:WP4216 | 0.00822185347081 | 0.4 | SMAD3 SMAD2 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05212 | 0.0105709544625 | 0.4 | SMAD3 SMAD2 | Pancreatic cancer |
| WP:WP4263 | 0.0112409645576 | 0.4 | SMAD3 SMAD2 | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-2173793 | 0.012121451174 | 0.4 | SMAD3 SMAD2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| GO:0007167 | 0.012144141891 | 1.0 | SMAD3 ZFYVE9 SMAD2 SMAD9 LEMD3 | enzyme linked receptor protein signaling pathway |
| WP:WP4540 | 0.0123508080289 | 0.4 | SMAD3 SMAD2 | Pathways Regulating Hippo Signaling |
| KEGG:05210 | 0.0141063112147 | 0.4 | SMAD3 SMAD2 | Colorectal cancer |
| KEGG:04659 | 0.0155166515839 | 0.4 | SMAD3 SMAD2 | Th17 cell differentiation |
| GO:0030512 | 0.0156368617465 | 0.6 | SMAD3 SMAD2 LEMD3 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:1903845 | 0.0156368617465 | 0.6 | SMAD3 SMAD2 LEMD3 | negative regulation of cellular response to transforming growth factor beta stimulus |
| KEGG:04933 | 0.0173728888545 | 0.4 | SMAD3 SMAD2 | AGE-RAGE signaling pathway in diabetic complications |
| WP:WP179 | 0.0219349325413 | 0.4 | SMAD3 SMAD2 | Cell Cycle |
| REAC:R-HSA-9614085 | 0.0221443716613 | 0.4 | SMAD3 SMAD2 | FOXO-mediated transcription |
| MIRNA:hsa-miR-503-3p | 0.0246863700739 | 0.4 | SMAD2 ZFYVE9 | hsa-miR-503-3p |
| CORUM:3039 | 0.0249780992026 | 0.2 | SMAD2 | SMAD2-FAST1 complex |
| WP:WP2853 | 0.0250517914711 | 0.4 | SMAD3 SMAD2 | Endoderm Differentiation |
| WP:WP2857 | 0.0271030899343 | 0.4 | SMAD3 SMAD2 | Mesodermal Commitment Pathway |
| WP:WP4239 | 0.0296692241758 | 0.4 | SMAD3 SMAD2 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04110 | 0.0301730300338 | 0.4 | SMAD3 SMAD2 | Cell cycle |
| REAC:R-HSA-170834 | 0.0304761248659 | 0.4 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex |
| KEGG:04371 | 0.0322094461771 | 0.4 | SMAD3 SMAD2 | Apelin signaling pathway |
| GO:0071495 | 0.0324891450538 | 1.0 | SMAD3 ZFYVE9 SMAD2 SMAD9 LEMD3 | cellular response to endogenous stimulus |
| WP:WP4666 | 0.0341988987854 | 0.4 | SMAD3 SMAD2 | Hepatitis B infection |
| KEGG:05226 | 0.0359303198923 | 0.4 | SMAD3 SMAD2 | Gastric cancer |
| KEGG:04390 | 0.0421802717446 | 0.4 | SMAD3 SMAD2 | Hippo signaling pathway |
| KEGG:04218 | 0.0439700127241 | 0.4 | SMAD3 SMAD2 | Cellular senescence |
| CORUM:0000000 | 0.0474603483533 | 1.0 | SMAD3 ZFYVE9 SMAD2 SMAD9 LEMD3 | CORUM root |
| GO:0090101 | 0.0493791608738 | 0.6 | SMAD3 SMAD2 LEMD3 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| CORUM:3750 | 0.0499494897235 | 0.2 | SMAD3 | CREBBP-SMAD3 hexameric complex |
| CORUM:3749 | 0.0499494897235 | 0.2 | SMAD2 | CREBBP-SMAD2 hexameric complex |
| CORUM:3733 | 0.0499494897235 | 0.2 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3729 | 0.0499494897235 | 0.2 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3199 | 0.0499494897235 | 0.2 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3198 | 0.0499494897235 | 0.2 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3038 | 0.0499494897235 | 0.2 | SMAD2 | SMAD2-SMAD4-FAST1 complex |
| CORUM:2968 | 0.0499494897235 | 0.2 | SMAD3 | Axin-SMAD3 complex |
| CORUM:2813 | 0.0499494897235 | 0.2 | SMAD3 | BRCA1-SMAD3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMAD3 | SMAD2 | 1.0 | 0.949 | bioplex (SMAD3) bioplex_WMM |
| SMAD3 | SMAD9 | 0.998 | 0.945 | bioplex (SMAD3) bioplex_WMM |
| SMAD3 | ZFYVE9 | 0.995 | 0.923 | hein_WMM bioplex (SMAD3) bioplex_WMM hein (SMAD3) |
| SMAD3 | LEMD3 | 0.953 | 0.858 | hein_WMM bioplex (SMAD3) bioplex_WMM hein (SMAD3) |
| SMAD9 | LEMD3 | 0.027 | 0.228 | bioplex (SMAD9) bioplex_WMM |
| SMAD2 | SMAD9 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| SMAD2 | ZFYVE9 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| SMAD9 | ZFYVE9 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| LEMD3 | ZFYVE9 | 0.008 | 0.081 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SMAD2 | LEMD3 | 0.007 | 0.006 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06844 has an average edge precision of 0.425 which is ranked 3065 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMAD9 | HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |
| ZFYVE9 | HuMAP2_05074 HuMAP2_05149 HuMAP2_06738 HuMAP2_06844 |
| SMAD2 | HuMAP2_04331 HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |
| SMAD3 | HuMAP2_04331 HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |
| LEMD3 | HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |