hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06845
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SBF2 | Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2) | UniProt NCBI |
| MTMR12 | Myotubularin-related protein 12 (Inactive phosphatidylinositol 3-phosphatase 12) (Phosphatidylinositol 3 phosphate 3-phosphatase adapter subunit) (3-PAP) (3-phosphatase adapter protein) | UniProt NCBI |
| MTMR2 | Myotubularin-related protein 2 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1483255 | 3.42035346017e-05 | 1.0 | MTMR12 MTMR2 SBF2 | PI Metabolism |
| REAC:R-HSA-1483257 | 0.00045921109135 | 1.0 | MTMR12 MTMR2 SBF2 | Phospholipid metabolism |
| REAC:R-HSA-1660516 | 0.000802944115303 | 0.666666666667 | MTMR12 MTMR2 | Synthesis of PIPs at the early endosome membrane |
| HP:0003431 | 0.00587799905401 | 0.666666666667 | SBF2 MTMR2 | Decreased motor nerve conduction velocity |
| HP:0040131 | 0.0068832170429 | 0.666666666667 | SBF2 MTMR2 | Abnormal motor nerve conduction velocity |
| REAC:R-HSA-1660499 | 0.00753685558378 | 0.666666666667 | SBF2 MTMR2 | Synthesis of PIPs at the plasma membrane |
| REAC:R-HSA-556833 | 0.0194595609558 | 1.0 | MTMR12 MTMR2 SBF2 | Metabolism of lipids |
| HP:0003130 | 0.0307019877242 | 0.666666666667 | SBF2 MTMR2 | Abnormal peripheral myelination |
| HP:0000762 | 0.032187516076 | 0.666666666667 | SBF2 MTMR2 | Decreased nerve conduction velocity |
| HP:0002936 | 0.0337079994886 | 0.666666666667 | SBF2 MTMR2 | Distal sensory impairment |
| HP:0040129 | 0.0352634284647 | 0.666666666667 | SBF2 MTMR2 | Abnormal nerve conduction velocity |
| HP:0003134 | 0.041834410056 | 0.666666666667 | SBF2 MTMR2 | Abnormality of peripheral nerve conduction |
| HP:0045010 | 0.044442515366 | 0.666666666667 | SBF2 MTMR2 | Abnormality of peripheral nerves |
| HPA:047020_03 | 0.044531062015 | 0.666666666667 | MTMR12 SBF2 | soft tissue 1; chondrocytes[Uncertain,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SBF2 | MTMR2 | 0.045 | 0.287 | hein_WMM hein (MTMR2) |
| MTMR2 | MTMR12 | 0.026 | 0.215 | hein_WMM hein (MTMR2) |
| SBF2 | MTMR12 | 0.008 | 0.024 | hein_WMM WMM_only |
Images
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Complex HuMAP2_06845 has an average edge precision of 0.175 which is ranked 6471 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SBF2 | HuMAP2_00969 HuMAP2_06845 |
| MTMR12 | HuMAP2_06845 |
| MTMR2 | HuMAP2_00969 HuMAP2_03509 HuMAP2_06845 |