hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06846
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DICER1 | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | UniProt NCBI |
| TARBP2 | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5381 | 2.25356268047e-10 | 1.0 | AGO2 TARBP2 DICER1 | RNA-induced silencing complex, RISC |
| CORUM:5377 | 2.25356268047e-10 | 1.0 | AGO2 TARBP2 DICER1 | RNA-induced silencing complex, RISC |
| CORUM:3032 | 9.0142507219e-10 | 1.0 | AGO2 TARBP2 DICER1 | RNA-induced silencing complex, RISC |
| CORUM:5378 | 4.50712536095e-09 | 1.0 | AGO2 TARBP2 DICER1 | TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10) |
| REAC:R-HSA-426486 | 3.77661405245e-08 | 1.0 | AGO2 TARBP2 DICER1 | Small interfering RNA (siRNA) biogenesis |
| GO:0035087 | 3.63274304092e-07 | 1.0 | AGO2 TARBP2 DICER1 | siRNA loading onto RISC involved in RNA interference |
| REAC:R-HSA-203927 | 9.09984147875e-07 | 1.0 | AGO2 TARBP2 DICER1 | MicroRNA (miRNA) biogenesis |
| GO:0035197 | 1.81637152046e-06 | 1.0 | AGO2 TARBP2 DICER1 | siRNA binding |
| GO:0035280 | 3.17865016081e-06 | 1.0 | AGO2 TARBP2 DICER1 | miRNA loading onto RISC involved in gene silencing by miRNA |
| GO:0070922 | 7.62876038594e-06 | 1.0 | AGO2 TARBP2 DICER1 | small RNA loading onto RISC |
| GO:0070578 | 7.62876038594e-06 | 1.0 | AGO2 TARBP2 DICER1 | RISC-loading complex |
| CORUM:1385 | 1.00675659188e-05 | 0.666666666667 | DICER1 AGO2 | DICER1-NCOA6-AGO2 complex |
| GO:0030422 | 1.08982291228e-05 | 1.0 | AGO2 TARBP2 DICER1 | production of siRNA involved in RNA interference |
| WP:WP2805 | 1.43854048007e-05 | 0.666666666667 | DICER1 AGO2 | exRNA mechanism of action and biogenesis |
| WP:WP2338 | 1.43854048007e-05 | 0.666666666667 | TARBP2 DICER1 | miRNA Biogenesis |
| WP:WP4549 | 1.59032344064e-05 | 1.0 | AGO2 TARBP2 DICER1 | Fragile X Syndrome |
| GO:0016442 | 2.59741127426e-05 | 1.0 | AGO2 TARBP2 DICER1 | RISC complex |
| GO:0031332 | 2.59741127426e-05 | 1.0 | AGO2 TARBP2 DICER1 | RNAi effector complex |
| GO:0016246 | 4.13224520905e-05 | 1.0 | AGO2 TARBP2 DICER1 | RNA interference |
| GO:0031054 | 4.13224520905e-05 | 1.0 | AGO2 TARBP2 DICER1 | pre-miRNA processing |
| REAC:R-HSA-211000 | 0.000168445978677 | 1.0 | AGO2 TARBP2 DICER1 | Gene Silencing by RNA |
| GO:1902555 | 0.000297521655052 | 1.0 | AGO2 TARBP2 DICER1 | endoribonuclease complex |
| GO:0010586 | 0.000297521655052 | 1.0 | AGO2 TARBP2 DICER1 | miRNA metabolic process |
| GO:1905348 | 0.000495506150782 | 1.0 | AGO2 TARBP2 DICER1 | endonuclease complex |
| GO:0061980 | 0.000594407580071 | 1.0 | AGO2 TARBP2 DICER1 | regulatory RNA binding |
| GO:0035196 | 0.00104259725275 | 1.0 | AGO2 TARBP2 DICER1 | production of miRNAs involved in gene silencing by miRNA |
| GO:0031050 | 0.00137862598403 | 1.0 | AGO2 TARBP2 DICER1 | dsRNA processing |
| GO:0070918 | 0.00137862598403 | 1.0 | AGO2 TARBP2 DICER1 | production of small RNA involved in gene silencing by RNA |
| MIRNA:hsa-miR-107 | 0.00240077956866 | 1.0 | AGO2 TARBP2 DICER1 | hsa-miR-107 |
| GO:0003725 | 0.00360649647245 | 1.0 | AGO2 TARBP2 DICER1 | double-stranded RNA binding |
| GO:0030423 | 0.00811409485621 | 0.666666666667 | TARBP2 DICER1 | targeting of mRNA for destruction involved in RNA interference |
| MIRNA:hsa-miR-103a-3p | 0.00842873649059 | 1.0 | AGO2 TARBP2 DICER1 | hsa-miR-103a-3p |
| MIRNA:hsa-miR-497-5p | 0.00879427177058 | 1.0 | AGO2 TARBP2 DICER1 | hsa-miR-497-5p |
| WP:WP2943 | 0.0142843877495 | 0.333333333333 | DICER1 | Hypoxia-mediated EMT and Stemness |
| GO:0070883 | 0.020283420769 | 0.666666666667 | TARBP2 DICER1 | pre-miRNA binding |
| MIRNA:hsa-miR-6856-3p | 0.0209343595239 | 0.666666666667 | TARBP2 AGO2 | hsa-miR-6856-3p |
| MIRNA:hsa-miR-31-3p | 0.0229240616855 | 0.666666666667 | DICER1 AGO2 | hsa-miR-31-3p |
| MIRNA:hsa-miR-195-5p | 0.0240347945582 | 1.0 | AGO2 TARBP2 DICER1 | hsa-miR-195-5p |
| MIRNA:hsa-miR-15a-5p | 0.0336703052435 | 1.0 | AGO2 TARBP2 DICER1 | hsa-miR-15a-5p |
| GO:0035195 | 0.0397775372938 | 1.0 | AGO2 TARBP2 DICER1 | gene silencing by miRNA |
| MIRNA:hsa-miR-15b-5p | 0.0399186652944 | 1.0 | AGO2 TARBP2 DICER1 | hsa-miR-15b-5p |
| GO:0035194 | 0.0480789908723 | 1.0 | AGO2 TARBP2 DICER1 | posttranscriptional gene silencing by RNA |
| GO:0016441 | 0.0490669153423 | 1.0 | AGO2 TARBP2 DICER1 | posttranscriptional gene silencing |
| CORUM:1387 | 0.0499776345577 | 0.333333333333 | AGO2 | TTP-AGO2 complex |
| CORUM:5360 | 0.0499776345577 | 0.333333333333 | AGO2 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DICER1 | TARBP2 | 0.994 | 0.923 | hein_WMM bioplex_WMM boldt youn_WMM hein (DICER1) boldt_WMM treiber_WMM |
| AGO2 | TARBP2 | 0.155 | 0.416 | hein_WMM youn (AGO2) bioplex_WMM youn_WMM hein (AGO2) |
| AGO2 | DICER1 | 0.066 | 0.35 | hein_WMM youn (AGO2) bioplex_WMM youn_WMM hein (AGO2) |
Images
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Complex HuMAP2_06846 has an average edge precision of 0.563 which is ranked 2117 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DICER1 | HuMAP2_03016 HuMAP2_03926 HuMAP2_06846 |
| TARBP2 | HuMAP2_03016 HuMAP2_03926 HuMAP2_06846 |
| AGO2 | HuMAP2_00288 HuMAP2_00976 HuMAP2_03926 HuMAP2_04674 HuMAP2_06846 |