hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06848
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AP2A2 | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | UniProt NCBI |
| CLINT1 | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | UniProt NCBI |
| AP2S1 | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | UniProt NCBI |
| AP2M1 | AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein) | UniProt NCBI |
| AP2A1 | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | UniProt NCBI |
| STON2 | Stonin-2 (Stoned B) | UniProt NCBI |
| BMP2K | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | UniProt NCBI |
| AP2B1 | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | UniProt NCBI |
| DAB2 | Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2) | UniProt NCBI |
| MYO6 | Unconventional myosin-VI (Unconventional myosin-6) | UniProt NCBI |
| MAP1A | Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | UniProt NCBI |
| PICALM | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | UniProt NCBI |
| EPS15 | Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p) | UniProt NCBI |
| CLTB | Clathrin light chain B (Lcb) | UniProt NCBI |
| GTSE1 | G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856825 | 2.71495913787e-17 | 0.666666666667 | AP2B1 EPS15 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | Cargo recognition for clathrin-mediated endocytosis |
| GO:0072583 | 5.04786968281e-17 | 0.6 | AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM AP2B1 AP2A1 | clathrin-dependent endocytosis |
| GO:0030276 | 8.7404121028e-16 | 0.6 | AP2A2 CLINT1 AP2M1 AP2S1 DAB2 CLTB PICALM AP2B1 AP2A1 | clathrin binding |
| REAC:R-HSA-8856828 | 1.29690422707e-15 | 0.666666666667 | AP2B1 EPS15 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | Clathrin-mediated endocytosis |
| GO:0005905 | 7.37466185218e-14 | 0.533333333333 | EPS15 AP2A2 AP2M1 AP2S1 DAB2 PICALM AP2B1 AP2A1 | clathrin-coated pit |
| REAC:R-HSA-5140745 | 1.51881335464e-13 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| REAC:R-HSA-5099900 | 2.65654569285e-13 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | WNT5A-dependent internalization of FZD4 |
| GO:0030125 | 3.16220065213e-13 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | clathrin vesicle coat |
| GO:0006897 | 3.66390082523e-13 | 0.8 | AP2B1 EPS15 MYO6 AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | endocytosis |
| GO:0030122 | 4.62150859702e-13 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | AP-2 adaptor complex |
| GO:0030128 | 4.62150859702e-13 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | clathrin coat of endocytic vesicle |
| GO:0045334 | 6.24566906369e-13 | 0.533333333333 | MYO6 AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | clathrin-coated endocytic vesicle |
| REAC:R-HSA-182218 | 7.93115832092e-13 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Nef Mediated CD8 Down-regulation |
| REAC:R-HSA-199991 | 1.22152151117e-12 | 0.8 | AP2B1 EPS15 MYO6 CLINT1 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | Membrane Trafficking |
| GO:0030132 | 1.3857341134e-12 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | clathrin coat of coated pit |
| GO:0035615 | 1.3857341134e-12 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | clathrin adaptor activity |
| REAC:R-HSA-5653656 | 2.32402008268e-12 | 0.8 | AP2B1 EPS15 MYO6 CLINT1 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | Vesicle-mediated transport |
| GO:0140312 | 3.46253996388e-12 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | cargo adaptor activity |
| GO:0030118 | 4.76077803554e-12 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | clathrin coat |
| GO:0006898 | 9.21749370336e-12 | 0.666666666667 | EPS15 AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM AP2B1 AP2A1 | receptor-mediated endocytosis |
| GO:0098657 | 9.95072912948e-12 | 0.8 | AP2B1 EPS15 MYO6 AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | import into cell |
| REAC:R-HSA-167590 | 1.66274797987e-11 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Nef Mediated CD4 Down-regulation |
| GO:0030131 | 2.82499283962e-11 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | clathrin adaptor complex |
| GO:0030136 | 4.60737164307e-11 | 0.6 | MYO6 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM AP2B1 AP2A1 | clathrin-coated vesicle |
| REAC:R-HSA-8866427 | 1.04340157797e-10 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | VLDLR internalisation and degradation |
| REAC:R-HSA-177504 | 1.69457830585e-10 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Retrograde neurotrophin signalling |
| KEGG:04961 | 2.7417567382e-10 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | Endocrine and other factor-regulated calcium reabsorption |
| GO:0030120 | 6.16446512778e-10 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | vesicle coat |
| REAC:R-HSA-3928665 | 8.14972732654e-10 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | EPH-ephrin mediated repulsion of cells |
| KEGG:04144 | 9.28759879538e-10 | 0.533333333333 | EPS15 AP2A2 AP2M1 AP2S1 DAB2 CLTB AP2B1 AP2A1 | Endocytosis |
| REAC:R-HSA-164938 | 1.12498398545e-09 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REAC:R-HSA-8964038 | 1.52590899279e-09 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | LDL clearance |
| KEGG:04721 | 1.70671738053e-09 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | Synaptic vesicle cycle |
| WP:WP4159 | 2.71323031896e-09 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | GABA receptor Signaling |
| GO:0030135 | 4.1314139122e-09 | 0.6 | MYO6 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM AP2B1 AP2A1 | coated vesicle |
| REAC:R-HSA-164952 | 5.56207570888e-09 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | The role of Nef in HIV-1 replication and disease pathogenesis |
| GO:0030669 | 7.75546810963e-09 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | clathrin-coated endocytic vesicle membrane |
| GO:0030119 | 7.75546810963e-09 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | AP-type membrane coat adaptor complex |
| GO:0036020 | 1.13272485327e-08 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | endolysosome membrane |
| REAC:R-HSA-8964043 | 1.54968071354e-08 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Plasma lipoprotein clearance |
| GO:0048475 | 1.57758287374e-08 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | coated membrane |
| GO:0030117 | 1.57758287374e-08 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | membrane coat |
| GO:0030665 | 2.11373738965e-08 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | clathrin-coated vesicle membrane |
| REAC:R-HSA-2682334 | 4.00647772889e-08 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | EPH-Ephrin signaling |
| WP:WP2267 | 4.55811824839e-08 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Synaptic Vesicle Pathway |
| REAC:R-HSA-4086400 | 5.66543815169e-08 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | PCP/CE pathway |
| GO:0032802 | 7.34623669015e-08 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | low-density lipoprotein particle receptor catabolic process |
| REAC:R-HSA-190873 | 8.82026316521e-08 | 0.266666666667 | MYO6 AP2M1 CLTB DAB2 | Gap junction degradation |
| GO:0036019 | 1.06794520904e-07 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | endolysosome |
| REAC:R-HSA-437239 | 1.58008522325e-07 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Recycling pathway of L1 |
| GO:0030139 | 4.70369138814e-07 | 0.533333333333 | MYO6 AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | endocytic vesicle |
| REAC:R-HSA-174824 | 4.90973268607e-07 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Plasma lipoprotein assembly, remodeling, and clearance |
| KEGG:05016 | 6.11951901441e-07 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | Huntington disease |
| GO:0032799 | 6.41687390724e-07 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | low-density lipoprotein receptor particle metabolic process |
| REAC:R-HSA-3858494 | 6.81985481336e-07 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | Beta-catenin independent WNT signaling |
| GO:0030662 | 1.05133372311e-06 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | coated vesicle membrane |
| GO:0050690 | 1.5992900276e-06 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | regulation of defense response to virus by virus |
| GO:0061024 | 1.72482240567e-06 | 0.666666666667 | AP2B1 EPS15 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | membrane organization |
| REAC:R-HSA-187037 | 1.91227984555e-06 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Signaling by NTRK1 (TRKA) |
| GO:0032801 | 4.11943814212e-06 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | receptor catabolic process |
| GO:0034383 | 4.11943814212e-06 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | low-density lipoprotein particle clearance |
| WP:WP4549 | 4.90950687207e-06 | 0.333333333333 | AP2B1 AP2M1 AP2A1 CLTB AP2S1 | Fragile X Syndrome |
| REAC:R-HSA-166520 | 5.86105742044e-06 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Signaling by NTRKs |
| REAC:R-HSA-190828 | 8.156765727e-06 | 0.266666666667 | MYO6 AP2M1 CLTB DAB2 | Gap junction trafficking |
| REAC:R-HSA-157858 | 9.20380384812e-06 | 0.266666666667 | MYO6 AP2M1 CLTB DAB2 | Gap junction trafficking and regulation |
| GO:0060071 | 9.84804398616e-06 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | Wnt signaling pathway, planar cell polarity pathway |
| GO:0090175 | 1.05377149621e-05 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | regulation of establishment of planar polarity |
| GO:0001736 | 1.46176265932e-05 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | establishment of planar polarity |
| GO:0007164 | 1.46176265932e-05 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | establishment of tissue polarity |
| REAC:R-HSA-373760 | 1.59723087718e-05 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | L1CAM interactions |
| GO:0048268 | 1.64056894873e-05 | 0.266666666667 | EPS15 PICALM CLTB AP2S1 | clathrin coat assembly |
| REAC:R-HSA-2132295 | 1.99321424423e-05 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | MHC class II antigen presentation |
| GO:0016192 | 2.55740706784e-05 | 0.8 | AP2B1 EPS15 MYO6 AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM STON2 AP2A1 | vesicle-mediated transport |
| WP:WP437 | 2.55866104184e-05 | 0.333333333333 | EPS15 AP2M1 AP2B1 AP2S1 AP2A1 | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-162909 | 2.56735849888e-05 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | Host Interactions of HIV factors |
| GO:0034381 | 2.93895851524e-05 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | plasma lipoprotein particle clearance |
| GO:0001738 | 3.17150101471e-05 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | morphogenesis of a polarized epithelium |
| REAC:R-HSA-196025 | 3.64801385431e-05 | 0.2 | AP2M1 CLTB DAB2 | Formation of annular gap junctions |
| GO:0030666 | 3.94875161267e-05 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | endocytic vesicle membrane |
| CORUM:3231 | 4.68677803909e-05 | 0.133333333333 | STON2 EPS15 | Eps15-stonin2 complex |
| GO:1905330 | 6.93918237641e-05 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | regulation of morphogenesis of an epithelium |
| REAC:R-HSA-195721 | 8.89884325333e-05 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | Signaling by WNT |
| GO:0035567 | 9.67635700828e-05 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | non-canonical Wnt signaling pathway |
| GO:0043112 | 0.000126849299529 | 0.4 | AP2B1 AP2M1 AP2A1 AP2A2 PICALM AP2S1 | receptor metabolic process |
| GO:0098852 | 0.000144743217172 | 0.466666666667 | MYO6 DAB2 AP2M1 AP2S1 AP2A2 AP2B1 AP2A1 | lytic vacuole membrane |
| GO:0005765 | 0.000144743217172 | 0.466666666667 | MYO6 DAB2 AP2M1 AP2S1 AP2A2 AP2B1 AP2A1 | lysosomal membrane |
| GO:2000027 | 0.000186231149356 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | regulation of animal organ morphogenesis |
| GO:0097006 | 0.000196475873636 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | regulation of plasma lipoprotein particle levels |
| REAC:R-HSA-5663205 | 0.000207173886673 | 0.4 | EPS15 AP2A2 AP2M1 AP2A1 AP2B1 AP2S1 | Infectious disease |
| GO:0005774 | 0.000351536354654 | 0.466666666667 | MYO6 DAB2 AP2M1 AP2S1 AP2A2 AP2B1 AP2A1 | vacuolar membrane |
| REAC:R-HSA-9006934 | 0.000438111864 | 0.4 | EPS15 AP2A2 AP2M1 AP2A1 AP2B1 AP2S1 | Signaling by Receptor Tyrosine Kinases |
| GO:0048013 | 0.000466818802352 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | ephrin receptor signaling pathway |
| REAC:R-HSA-162906 | 0.000513949188049 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | HIV Infection |
| GO:0019886 | 0.000974115350567 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 0.00103083695684 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 0.0010901566802 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| GO:0006810 | 0.00131470151059 | 0.933333333333 | AP2B1 EPS15 MYO6 GTSE1 AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM STON2 AP2A1 MAP1A | transport |
| REAC:R-HSA-422475 | 0.0016736786063 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | Axon guidance |
| GO:0051234 | 0.00196583708722 | 0.933333333333 | AP2B1 EPS15 MYO6 GTSE1 AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM STON2 AP2A1 MAP1A | establishment of localization |
| GO:0044437 | 0.00490836175354 | 0.466666666667 | MYO6 DAB2 AP2M1 AP2S1 AP2A2 AP2B1 AP2A1 | vacuolar part |
| GO:0030100 | 0.00607426704128 | 0.333333333333 | DAB2 BMP2K PICALM AP2S1 STON2 | regulation of endocytosis |
| GO:0002009 | 0.00816490084325 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | morphogenesis of an epithelium |
| GO:0098805 | 0.0104637653326 | 0.6 | MYO6 AP2A2 AP2M1 AP2S1 DAB2 CLTB PICALM AP2B1 AP2A1 | whole membrane |
| GO:0030659 | 0.0105160918313 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | cytoplasmic vesicle membrane |
| GO:0000323 | 0.012058723418 | 0.466666666667 | MYO6 DAB2 AP2M1 AP2S1 AP2A2 AP2B1 AP2A1 | lytic vacuole |
| GO:0005764 | 0.012058723418 | 0.466666666667 | MYO6 DAB2 AP2M1 AP2S1 AP2A2 AP2B1 AP2A1 | lysosome |
| REAC:R-HSA-199992 | 0.0127082510208 | 0.2 | PICALM CLTB CLINT1 | trans-Golgi Network Vesicle Budding |
| GO:0012506 | 0.0127272667396 | 0.466666666667 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB PICALM AP2A1 | vesicle membrane |
| GO:0002478 | 0.0202891594379 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | antigen processing and presentation of exogenous peptide antigen |
| GO:0005829 | 0.020919881065 | 0.933333333333 | AP2B1 EPS15 MYO6 GTSE1 AP2A2 AP2M1 CLINT1 AP2S1 DAB2 CLTB PICALM STON2 AP2A1 MAP1A | cytosol |
| GO:0019884 | 0.0215568476407 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | antigen processing and presentation of exogenous antigen |
| GO:0005773 | 0.026565840532 | 0.466666666667 | MYO6 DAB2 AP2M1 AP2S1 AP2A2 AP2B1 AP2A1 | vacuole |
| GO:0048002 | 0.0272694824137 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | antigen processing and presentation of peptide antigen |
| GO:1903077 | 0.0278624171613 | 0.2 | AP2M1 PICALM DAB2 | negative regulation of protein localization to plasma membrane |
| GO:0048729 | 0.0349032363334 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | tissue morphogenesis |
| GO:1904376 | 0.0396559562015 | 0.2 | AP2M1 PICALM DAB2 | negative regulation of protein localization to cell periphery |
| GO:1903828 | 0.0409407294263 | 0.266666666667 | AP2M1 PICALM MAP1A DAB2 | negative regulation of cellular protein localization |
| GO:0016055 | 0.0424705025507 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | Wnt signaling pathway |
| GO:0198738 | 0.0452737504689 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 DAB2 AP2A1 | cell-cell signaling by wnt |
| REAC:R-HSA-1266738 | 0.0456201439403 | 0.4 | AP2B1 AP2M1 AP2S1 AP2A2 CLTB AP2A1 | Developmental Biology |
| GO:0050750 | 0.0466258627685 | 0.2 | AP2M1 AP2A1 PICALM | low-density lipoprotein particle receptor binding |
| GO:0019882 | 0.0493298776357 | 0.333333333333 | AP2A2 AP2M1 AP2B1 AP2S1 AP2A1 | antigen processing and presentation |
| GO:0051179 | 0.0497228567502 | 0.933333333333 | AP2B1 EPS15 MYO6 GTSE1 AP2A2 AP2M1 BMP2K AP2S1 DAB2 CLTB PICALM STON2 AP2A1 MAP1A | localization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AP2A1 | AP2B1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| AP2M1 | AP2A1 | 1.0 | 0.949 | hein_WMM bioplex (AP2M1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EPS15 | AP2M1 | 1.0 | 0.949 | hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM |
| AP2M1 | AP2A2 | 1.0 | 0.949 | bioplex (AP2M1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AP2M1 | AP2S1 | 0.999 | 0.949 | hein_WMM bioplex (AP2M1,AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AP2M1 | STON2 | 0.998 | 0.938 | hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM |
| AP2M1 | BMP2K | 0.998 | 0.937 | hein_WMM bioplex (AP2M1) bioplex_WMM youn_WMM gupta_WMM |
| AP2S1 | AP2A1 | 0.98 | 0.896 | hein_WMM bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AP2A2 | AP2S1 | 0.971 | 0.883 | bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AP2S1 | AP2B1 | 0.889 | 0.818 | hein_WMM bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AP2M1 | AP2B1 | 0.869 | 0.803 | hein_WMM bioplex (AP2M1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| PICALM | BMP2K | 0.751 | 0.743 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| CLTB | AP2A1 | 0.688 | 0.713 | hein_WMM bioplex_WMM boldt hein (CLTB) fraction boldt_WMM |
| AP2S1 | STON2 | 0.657 | 0.696 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM |
| EPS15 | AP2S1 | 0.483 | 0.613 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM gupta_WMM |
| CLTB | CLINT1 | 0.47 | 0.605 | hein_WMM bioplex (CLINT1) bioplex_WMM boldt hein (CLTB) boldt_WMM |
| DAB2 | CLTB | 0.362 | 0.544 | hein_WMM bioplex (DAB2) bioplex_WMM hein (CLTB) fraction |
| CLTB | PICALM | 0.338 | 0.527 | hein_WMM bioplex (PICALM) bioplex_WMM hein (CLTB,PICALM) |
| AP2M1 | CLTB | 0.327 | 0.516 | hein_WMM bioplex (AP2M1) bioplex_WMM boldt hein (CLTB) boldt_WMM |
| BMP2K | CLINT1 | 0.27 | 0.483 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| AP2S1 | BMP2K | 0.256 | 0.479 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM |
| MYO6 | CLTB | 0.218 | 0.466 | hein_WMM bioplex (MYO6) bioplex_WMM hein (CLTB) fraction |
| GTSE1 | PICALM | 0.216 | 0.464 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (GTSE1,PICALM) gupta_WMM |
| CLINT1 | AP2B1 | 0.193 | 0.446 | hein_WMM bioplex (CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AP2A2 | AP2B1 | 0.161 | 0.417 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| CLTB | AP2B1 | 0.126 | 0.4 | hein_WMM bioplex_WMM boldt hein (CLTB) boldt_WMM |
| CLTB | STON2 | 0.117 | 0.389 | hein_WMM bioplex_WMM hein (CLTB) |
| CLTB | BMP2K | 0.115 | 0.385 | hein_WMM bioplex_WMM hein (CLTB) |
| CLTB | GTSE1 | 0.085 | 0.35 | hein_WMM bioplex (GTSE1) bioplex_WMM hein (CLTB,GTSE1) |
| CLTB | MAP1A | 0.085 | 0.348 | fraction |
| EPS15 | PICALM | 0.082 | 0.351 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| MYO6 | STON2 | 0.081 | 0.351 | hein_WMM bioplex (MYO6) bioplex_WMM gupta_WMM |
| STON2 | PICALM | 0.077 | 0.352 | hein_WMM bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| AP2A2 | AP2A1 | 0.066 | 0.349 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| AP2M1 | PICALM | 0.061 | 0.334 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (PICALM) gupta_WMM fraction |
| PICALM | CLINT1 | 0.055 | 0.311 | hein_WMM bioplex (PICALM) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STON2 | CLINT1 | 0.054 | 0.302 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| EPS15 | CLTB | 0.054 | 0.3 | hein_WMM bioplex_WMM hein (CLTB) fraction |
| CLINT1 | AP2A1 | 0.052 | 0.299 | hein_WMM bioplex (CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| AP2S1 | CLTB | 0.052 | 0.302 | hein_WMM bioplex_WMM boldt hein (CLTB) boldt_WMM |
| DAB2 | AP2A1 | 0.05 | 0.298 | hein_WMM bioplex (DAB2) bioplex_WMM youn_WMM |
| GTSE1 | CLINT1 | 0.044 | 0.276 | hein_WMM bioplex (GTSE1) bioplex_WMM youn_WMM hein (GTSE1) gupta_WMM fraction |
| BMP2K | AP2A1 | 0.036 | 0.263 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PICALM | AP2B1 | 0.032 | 0.24 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| AP2A2 | CLINT1 | 0.029 | 0.23 | bioplex (CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| STON2 | GTSE1 | 0.024 | 0.214 | hein_WMM bioplex_WMM hein (GTSE1) gupta_WMM |
| DAB2 | AP2M1 | 0.023 | 0.21 | hein_WMM bioplex (DAB2) bioplex_WMM youn_WMM |
| GTSE1 | AP2A1 | 0.022 | 0.208 | hein_WMM bioplex (GTSE1) bioplex_WMM youn_WMM hein (GTSE1) gupta_WMM |
| GTSE1 | BMP2K | 0.021 | 0.185 | hein_WMM bioplex_WMM hein (GTSE1) gupta_WMM |
| STON2 | BMP2K | 0.018 | 0.176 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| DAB2 | AP2B1 | 0.017 | 0.175 | hein_WMM bioplex (DAB2) bioplex_WMM youn_WMM |
| BMP2K | AP2B1 | 0.014 | 0.138 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| EPS15 | BMP2K | 0.012 | 0.148 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP2M1 | CLINT1 | 0.012 | 0.149 | hein_WMM bioplex (AP2M1,CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| EPS15 | STON2 | 0.012 | 0.148 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| EPS15 | AP2A2 | 0.012 | 0.147 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP2M1 | GTSE1 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM hein (GTSE1) gupta_WMM |
| DAB2 | MYO6 | 0.012 | 0.149 | hein_WMM bioplex (DAB2) bioplex_WMM |
| STON2 | AP2B1 | 0.01 | 0.14 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP2A2 | STON2 | 0.01 | 0.12 | bioplex_WMM youn_WMM WMM_only |
| AP2A2 | BMP2K | 0.01 | 0.098 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DAB2 | CLINT1 | 0.009 | 0.11 | hein_WMM bioplex (DAB2) bioplex_WMM youn_WMM |
| DAB2 | STON2 | 0.009 | 0.096 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MYO6 | AP2B1 | 0.009 | 0.096 | hein_WMM bioplex (MYO6) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| EPS15 | DAB2 | 0.008 | 0.083 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| STON2 | AP2A1 | 0.008 | 0.077 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| DAB2 | BMP2K | 0.008 | 0.011 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AP2S1 | CLINT1 | 0.007 | 0.008 | hein_WMM bioplex (AP2S1,CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DAB2 | AP2A2 | 0.007 | 0.008 | bioplex_WMM youn_WMM WMM_only |
| AP2A2 | GTSE1 | 0.007 | 0.002 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CLINT1 | MAP1A | 0.007 | 0.003 | gupta_WMM WMM_only |
| DAB2 | AP2S1 | 0.007 | 0.002 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AP2M1 | MAP1A | 0.007 | 0.001 | gupta_WMM WMM_only |
| GTSE1 | MAP1A | 0.007 | 0.0 | gupta_WMM WMM_only |
| STON2 | MAP1A | 0.007 | 0.0 | gupta_WMM WMM_only |
| EPS15 | MAP1A | 0.007 | 0.002 | gupta_WMM WMM_only |
| PICALM | MAP1A | 0.007 | 0.0 | gupta_WMM WMM_only |
| DAB2 | PICALM | 0.007 | 0.002 | hein_WMM bioplex_WMM youn_WMM hein (PICALM) |
| EPS15 | CLINT1 | 0.007 | 0.005 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP2S1 | GTSE1 | 0.007 | 0.003 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MYO6 | CLINT1 | 0.007 | 0.004 | hein_WMM bioplex (CLINT1,MYO6) bioplex_WMM youn_WMM gupta_WMM |
| AP2S1 | MYO6 | 0.006 | 0.002 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM gupta_WMM |
| EPS15 | AP2B1 | 0.005 | 0.006 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| DAB2 | GTSE1 | 0.004 | 0.008 | hein_WMM hein (GTSE1) |
| EPS15 | GTSE1 | 0.004 | 0.012 | hein_WMM bioplex_WMM youn_WMM hein (GTSE1) gupta_WMM |
| MYO6 | BMP2K | 0.004 | 0.011 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| EPS15 | AP2A1 | 0.003 | 0.013 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| AP2S1 | PICALM | 0.003 | 0.011 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM gupta_WMM |
| PICALM | AP2A1 | 0.0 | 0.014 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM gupta_WMM fraction |
| GTSE1 | AP2B1 | 0.0 | 0.013 | hein_WMM bioplex (GTSE1) bioplex_WMM youn_WMM hein (GTSE1) gupta_WMM |
| MYO6 | PICALM | 0.0 | 0.016 | hein_WMM bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| MYO6 | MAP1A | 0.0 | 0.012 | gupta_WMM fraction |
| EPS15 | MYO6 | 0.0 | 0.013 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| AP2M1 | MYO6 | 0.0 | 0.006 | hein_WMM bioplex (MYO6) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP2A2 | PICALM | 0.0 | 0.008 | bioplex (PICALM) bioplex_WMM youn_WMM gupta_WMM fraction |
| AP2A1 | MAP1A | 0.0 | 0.011 | gupta_WMM fraction |
| AP2A2 | MAP1A | 0.0 | 0.012 | gupta_WMM fraction |
| AP2B1 | MAP1A | 0.0 | 0.008 | bioplex_WMM gupta_WMM fraction |
| MYO6 | GTSE1 | 0.0 | 0.008 | hein_WMM youn_WMM hein (GTSE1) gupta_WMM |
| MYO6 | AP2A1 | 0.0 | 0.005 | hein_WMM bioplex (MYO6) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP2A2 | MYO6 | 0.0 | 0.0 | bioplex (MYO6) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| AP2A2 | CLTB | 0.0 | 0.003 | bioplex_WMM boldt fraction boldt_WMM |
Images
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Complex HuMAP2_06848 has an average edge precision of 0.269 which is ranked 5056 out of all 6965 complexes.
Related Complexes