hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06851
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLR3D | DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog) | UniProt NCBI |
| POLR3H | DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9) | UniProt NCBI |
| CRCP | DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17) | UniProt NCBI |
| POLR3B | DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B) | UniProt NCBI |
| POLR3A | DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160) | UniProt NCBI |
| POLR3F | DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39) | UniProt NCBI |
| POLR3G | DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32) | UniProt NCBI |
| POLR3C | DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-73780 | 1.29426938106e-22 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Chain Elongation |
| REAC:R-HSA-73980 | 1.45024543467e-21 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Transcription Termination |
| REAC:R-HSA-76066 | 6.56651377153e-21 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| REAC:R-HSA-76071 | 9.19311928015e-21 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| REAC:R-HSA-76061 | 9.19311928015e-21 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| GO:0005666 | 3.64983965458e-20 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA polymerase III complex |
| REAC:R-HSA-76046 | 8.95037056592e-20 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Transcription Initiation |
| REAC:R-HSA-74158 | 2.8261156341e-19 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Transcription |
| REAC:R-HSA-749476 | 2.8261156341e-19 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA Polymerase III Abortive And Retractive Initiation |
| REAC:R-HSA-1834949 | 1.14552059564e-17 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | Cytosolic sensors of pathogen-associated DNA |
| KEGG:03020 | 2.42738007125e-17 | 0.875 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA polymerase |
| GO:0003899 | 3.22028160292e-17 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | DNA-directed 5'-3' RNA polymerase activity |
| GO:0034062 | 6.41459319292e-17 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | 5'-3' RNA polymerase activity |
| GO:0097747 | 6.41459319292e-17 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA polymerase activity |
| GO:0001056 | 1.41977569805e-16 | 0.875 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3H | RNA polymerase III activity |
| KEGG:04623 | 3.57917047757e-15 | 0.875 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | Cytosolic DNA-sensing pathway |
| GO:0032481 | 3.69184923393e-15 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | positive regulation of type I interferon production |
| WP:WP4655 | 1.21402982622e-14 | 0.875 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | Cytosolic DNA-sensing pathway |
| WP:WP4022 | 3.62773956352e-14 | 0.875 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | Pyrimidine metabolism |
| GO:0055029 | 1.1060204938e-13 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 1.20543806627e-13 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | DNA-directed RNA polymerase complex |
| GO:0030880 | 1.55215269403e-13 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | RNA polymerase complex |
| GO:0032479 | 1.82913258452e-13 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | regulation of type I interferon production |
| GO:0032606 | 1.98316480216e-13 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | type I interferon production |
| GO:0016779 | 3.68276491178e-13 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | nucleotidyltransferase activity |
| GO:0032728 | 9.31263837262e-12 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | positive regulation of interferon-beta production |
| GO:0061695 | 1.11425010437e-10 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | transferase complex, transferring phosphorus-containing groups |
| GO:0032648 | 1.23913839799e-10 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | regulation of interferon-beta production |
| GO:0032608 | 1.79420030701e-10 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | interferon-beta production |
| GO:0001819 | 9.92550829631e-10 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | positive regulation of cytokine production |
| GO:0140098 | 1.52860686774e-09 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | catalytic activity, acting on RNA |
| GO:0001817 | 2.62763921411e-08 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | regulation of cytokine production |
| REAC:R-HSA-168249 | 2.97983159355e-08 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | Innate Immune System |
| GO:0001816 | 5.05252358556e-08 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | cytokine production |
| REAC:R-HSA-74160 | 5.36908321467e-07 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | Gene expression (Transcription) |
| GO:0006383 | 6.24511523858e-07 | 0.625 | POLR3G CRCP POLR3C POLR3H POLR3F | transcription by RNA polymerase III |
| GO:1990234 | 1.1325412216e-06 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | transferase complex |
| GO:0016772 | 2.59637798767e-06 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | transferase activity, transferring phosphorus-containing groups |
| REAC:R-HSA-168256 | 6.52691464423e-06 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | Immune System |
| GO:0051240 | 2.02763540932e-05 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | positive regulation of multicellular organismal process |
| WP:WP405 | 5.43505087196e-05 | 0.375 | POLR3D POLR3H POLR3B | Eukaryotic Transcription Initiation |
| GO:1902494 | 8.40314286631e-05 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | catalytic complex |
| GO:0016740 | 0.0024739987919 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | transferase activity |
| GO:0051239 | 0.00373367296573 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | regulation of multicellular organismal process |
| GO:0045087 | 0.00389010538427 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | innate immune response |
| GO:0006359 | 0.00779479116974 | 0.375 | POLR3F POLR3C POLR3G | regulation of transcription by RNA polymerase III |
| GO:0045089 | 0.00826594476043 | 0.625 | POLR3G POLR3D POLR3C POLR3B POLR3F | positive regulation of innate immune response |
| GO:0002833 | 0.00990176358857 | 0.625 | POLR3G POLR3D POLR3C POLR3B POLR3F | positive regulation of response to biotic stimulus |
| GO:0098542 | 0.010046644003 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | defense response to other organism |
| WP:000000 | 0.0134045376724 | 1.0 | CRCP POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G POLR3H | WIKIPATHWAYS |
| GO:0045088 | 0.0186653759009 | 0.625 | POLR3G POLR3D POLR3C POLR3B POLR3F | regulation of innate immune response |
| GO:0031349 | 0.0197463295107 | 0.625 | POLR3G POLR3D POLR3C POLR3B POLR3F | positive regulation of defense response |
| HP:0002127 | 0.0253031982095 | 0.25 | POLR3B POLR3A | Abnormal upper motor neuron morphology |
| GO:0002831 | 0.0306971650449 | 0.625 | POLR3G POLR3D POLR3C POLR3B POLR3F | regulation of response to biotic stimulus |
| GO:0043207 | 0.0333324587478 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | response to external biotic stimulus |
| GO:0051707 | 0.0333324587478 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | response to other organism |
| GO:0009607 | 0.0379394674021 | 0.75 | POLR3C POLR3D POLR3B POLR3F POLR3A POLR3G | response to biotic stimulus |
| GO:0043902 | 0.0460018984255 | 0.625 | POLR3G POLR3D POLR3C POLR3B POLR3F | positive regulation of multi-organism process |
| GO:0032103 | 0.0499151083008 | 0.625 | POLR3G POLR3D POLR3C POLR3B POLR3F | positive regulation of response to external stimulus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| 101060521 | POLR3F | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3D | POLR3F | 1.0 | 0.949 | hein_WMM bioplex (POLR3D) bioplex_WMM Malo fraction |
| POLR3H | POLR3C | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3C | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3D | POLR3C | 1.0 | 0.949 | hein_WMM bioplex (POLR3D) bioplex_WMM Malo fraction |
| POLR3A | POLR3F | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3H | POLR3F | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3D | POLR3G | 1.0 | 0.949 | hein_WMM bioplex (POLR3D) bioplex_WMM Malo fraction |
| POLR3H | POLR3B | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| POLR3B | POLR3G | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3H | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3B | POLR3F | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3A | POLR3G | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3B | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| 101060521 | POLR3G | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| POLR3H | POLR3G | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3A | 1.0 | 0.949 | hein_WMM hein (101060521) Malo fraction |
| CRCP | POLR3C | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| CRCP | POLR3F | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3H | POLR3A | 0.999 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| POLR3B | POLR3C | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| POLR3G | POLR3C | 0.999 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR3D | POLR3A | 0.998 | 0.941 | hein_WMM bioplex (POLR3D) bioplex_WMM Guru Malo fraction |
| POLR3A | POLR3C | 0.998 | 0.94 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| POLR3B | POLR3A | 0.996 | 0.927 | hein_WMM bioplex_WMM Guru Malo fraction |
| POLR3F | POLR3G | 0.995 | 0.923 | hein_WMM bioplex_WMM Guru Malo fraction |
| 101060521 | CRCP | 0.992 | 0.912 | hein_WMM hein (101060521) Malo fraction |
| POLR3D | POLR3B | 0.991 | 0.91 | hein_WMM bioplex (POLR3D) bioplex_WMM Guru Malo fraction |
| CRCP | POLR3B | 0.986 | 0.901 | hein_WMM bioplex_WMM Malo fraction |
| CRCP | POLR3D | 0.972 | 0.886 | hein_WMM bioplex (POLR3D) bioplex_WMM |
| POLR3D | POLR3H | 0.971 | 0.882 | hein_WMM bioplex (POLR3D) bioplex_WMM |
| CRCP | POLR3A | 0.917 | 0.84 | hein_WMM bioplex_WMM Malo fraction |
| 101060521 | POLR3D | 0.881 | 0.816 | hein_WMM hein (101060521) Malo fraction |
| POLR3F | POLR3C | 0.189 | 0.441 | hein_WMM bioplex_WMM Malo fraction |
| CRCP | POLR3H | 0.019 | 0.182 | hein_WMM bioplex_WMM WMM_only |
| CRCP | POLR3G | 0.017 | 0.168 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06851 has an average edge precision of 0.876 which is ranked 674 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| POLR3D | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3H | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| CRCP | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3B | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3A | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3F | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3G | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |
| POLR3C | HuMAP2_00731 HuMAP2_01470 HuMAP2_03631 HuMAP2_06851 |