hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06855
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | UniProt NCBI |
| ATG16L1 | Autophagy-related protein 16-1 (APG16-like 1) | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | UniProt NCBI |
| ATG10 | Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (APG10-like) | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | UniProt NCBI |
| MAP1LC3B2 | Microtubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2509 | 1.06869902248e-12 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Nanoparticle triggered autophagic cell death |
| KEGG:04136 | 7.72151753394e-12 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Autophagy - other |
| WP:WP4577 | 3.90186549855e-11 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway |
| WP:WP615 | 1.67816026181e-09 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Senescence and Autophagy in Cancer |
| REAC:R-HSA-1632852 | 5.92723989799e-09 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Macroautophagy |
| REAC:R-HSA-9612973 | 1.4030126133e-08 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Autophagy |
| KEGG:04140 | 1.45224457553e-08 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Autophagy - animal |
| GO:0000045 | 1.10316613839e-06 | 0.833333333333 | ATG5 ATG12 ATG3 MAP1LC3B2 ATG16L1 | autophagosome assembly |
| GO:1905037 | 1.17664441353e-06 | 0.833333333333 | ATG5 ATG12 ATG3 MAP1LC3B2 ATG16L1 | autophagosome organization |
| GO:0016236 | 1.21660050468e-06 | 1.0 | ATG5 ATG3 ATG10 MAP1LC3B2 ATG12 ATG16L1 | macroautophagy |
| GO:0019776 | 1.81637152046e-06 | 0.5 | ATG5 ATG3 ATG12 | Atg8 ligase activity |
| GO:0007033 | 1.45244802245e-05 | 0.833333333333 | ATG5 ATG12 ATG3 MAP1LC3B2 ATG16L1 | vacuole organization |
| GO:0061919 | 1.67630347668e-05 | 1.0 | ATG5 ATG3 ATG10 MAP1LC3B2 ATG12 ATG16L1 | process utilizing autophagic mechanism |
| GO:0006914 | 1.67630347668e-05 | 1.0 | ATG5 ATG3 ATG10 MAP1LC3B2 ATG12 ATG16L1 | autophagy |
| REAC:R-HSA-8953897 | 3.54263477159e-05 | 0.833333333333 | ATG5 ATG10 ATG12 ATG3 ATG16L1 | Cellular responses to external stimuli |
| GO:0000422 | 0.000154355035659 | 0.666666666667 | ATG5 ATG12 ATG3 MAP1LC3B2 | autophagy of mitochondrion |
| GO:0061726 | 0.000154355035659 | 0.666666666667 | ATG5 ATG12 ATG3 MAP1LC3B2 | mitochondrion disassembly |
| GO:0005776 | 0.000216594058417 | 0.666666666667 | ATG5 ATG12 ATG16L1 MAP1LC3B2 | autophagosome |
| GO:1903008 | 0.000666750687757 | 0.666666666667 | ATG5 ATG12 ATG3 MAP1LC3B2 | organelle disassembly |
| REAC:R-HSA-8934903 | 0.000797179114843 | 0.333333333333 | ATG5 ATG12 | Receptor Mediated Mitophagy |
| KEGG:04621 | 0.00105950907114 | 0.5 | ATG5 ATG16L1 ATG12 | NOD-like receptor signaling pathway |
| REAC:R-HSA-5205685 | 0.00377982352449 | 0.333333333333 | ATG5 ATG12 | Pink/Parkin Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.0060953046166 | 0.333333333333 | ATG5 ATG12 | Mitophagy |
| GO:0019777 | 0.00676235117068 | 0.333333333333 | ATG10 ATG3 | Atg12 transferase activity |
| WP:WP3865 | 0.00792327646772 | 0.333333333333 | ATG5 ATG12 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| REAC:R-HSA-936440 | 0.0102563889288 | 0.333333333333 | ATG5 ATG12 | Negative regulators of DDX58/IFIH1 signaling |
| KEGG:04622 | 0.0124835568261 | 0.333333333333 | ATG5 ATG12 | RIG-I-like receptor signaling pathway |
| WP:WP4655 | 0.0125813796702 | 0.333333333333 | ATG5 ATG12 | Cytosolic DNA-sensing pathway |
| GO:0034274 | 0.020283420769 | 0.333333333333 | ATG5 ATG12 | Atg12-Atg5-Atg16 complex |
| GO:0006501 | 0.0405595771497 | 0.333333333333 | ATG5 ATG12 | C-terminal protein lipidation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATG16L1 | ATG5 | 0.993 | 0.918 | bioplex_WMM Guru Malo fraction |
| ATG5 | ATG3 | 0.543 | 0.644 | bioplex (ATG3) bioplex_WMM |
| ATG16L1 | ATG3 | 0.482 | 0.612 | bioplex (ATG3) bioplex_WMM |
| ATG3 | ATG12 | 0.47 | 0.605 | bioplex (ATG3) bioplex_WMM |
| ATG10 | ATG12 | 0.232 | 0.47 | bioplex (ATG10) bioplex_WMM |
| ATG3 | MAP1LC3B2 | 0.036 | 0.265 | bioplex (ATG3) bioplex_WMM |
| ATG16L1 | ATG12 | 0.008 | 0.048 | bioplex_WMM WMM_only |
| ATG12 | MAP1LC3B2 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| ATG5 | MAP1LC3B2 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| ATG16L1 | MAP1LC3B2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| ATG5 | ATG12 | 0.006 | 0.007 | bioplex_WMM fraction |
Images
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Complex HuMAP2_06855 has an average edge precision of 0.328 which is ranked 4238 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATG3 | HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG16L1 | HuMAP2_02085 HuMAP2_02846 HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG5 | HuMAP2_02085 HuMAP2_03674 HuMAP2_06392 HuMAP2_06855 |
| ATG10 | HuMAP2_03674 HuMAP2_06023 HuMAP2_06855 |
| ATG12 | HuMAP2_03674 HuMAP2_06023 HuMAP2_06855 |
| MAP1LC3B2 | HuMAP2_06855 |