hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06856
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| STK4 | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | UniProt NCBI |
| STK3 | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | UniProt NCBI |
| RASSF2 | Ras association domain-containing protein 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6716 | 1.00675659188e-05 | 0.666666666667 | STK4 STK3 | DLG5-MST1-MST2 complex |
| KEGG:04392 | 0.000145390917053 | 0.666666666667 | STK3 RASSF2 | Hippo signaling pathway - multiple species |
| REAC:R-HSA-2028269 | 0.00114404160216 | 0.666666666667 | STK4 STK3 | Signaling by Hippo |
| KEGG:04010 | 0.0144512154105 | 0.666666666667 | STK4 STK3 | MAPK signaling pathway |
| MIRNA:hsa-miR-3656 | 0.0166420052318 | 0.666666666667 | STK4 RASSF2 | hsa-miR-3656 |
| WP:WP382 | 0.0226746026379 | 0.666666666667 | STK4 STK3 | MAPK Signaling Pathway |
| CORUM:6403 | 0.0499776345577 | 0.333333333333 | STK4 | MST1-SAV1 complex |
| CORUM:6404 | 0.0499776345577 | 0.333333333333 | STK3 | MST2-SAV1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STK4 | STK3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| STK4 | RASSF2 | 0.988 | 0.901 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
| STK3 | RASSF2 | 0.977 | 0.893 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
Images
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Complex HuMAP2_06856 has an average edge precision of 0.914 which is ranked 494 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| STK4 | HuMAP2_02757 HuMAP2_03087 HuMAP2_05897 HuMAP2_05914 HuMAP2_06039 HuMAP2_06856 |
| STK3 | HuMAP2_02757 HuMAP2_03087 HuMAP2_05897 HuMAP2_05914 HuMAP2_06039 HuMAP2_06856 |
| RASSF2 | HuMAP2_02757 HuMAP2_03087 HuMAP2_05897 HuMAP2_05914 HuMAP2_06856 |