hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06859
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TRPM3 | Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2) | UniProt NCBI |
| C5orf22 | UPF0489 protein C5orf22 | UniProt NCBI |
| OSM | Oncostatin-M (OSM) | UniProt NCBI |
| IL6ST | Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6788467 | 0.000663071622452 | 0.5 | IL6ST OSM | IL-6-type cytokine receptor ligand interactions |
| REAC:R-HSA-6783589 | 0.00171688133139 | 0.5 | IL6ST OSM | Interleukin-6 family signaling |
| WP:WP2374 | 0.00336828295894 | 0.5 | IL6ST OSM | Oncostatin M Signaling Pathway |
| WP:WP236 | 0.00997499186767 | 0.5 | IL6ST OSM | Adipogenesis |
| KEGG:04630 | 0.014392043024 | 0.5 | IL6ST OSM | JAK-STAT signaling pathway |
| GO:0038165 | 0.0162267366884 | 0.5 | IL6ST OSM | oncostatin-M-mediated signaling pathway |
| KEGG:04060 | 0.0251274353406 | 0.5 | IL6ST OSM | Cytokine-cytokine receptor interaction |
| CORUM:3229 | 0.0499140284799 | 0.25 | IL6ST | CDK9-IL6ST complex |
| CORUM:5582 | 0.0499140284799 | 0.25 | IL6ST | LIFR-LIF-gp130 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OSM | IL6ST | 0.764 | 0.749 | bioplex (OSM) bioplex_WMM |
| OSM | TRPM3 | 0.074 | 0.357 | bioplex (OSM) bioplex_WMM |
| OSM | C5orf22 | 0.053 | 0.301 | bioplex (OSM) bioplex_WMM |
| IL6ST | C5orf22 | 0.009 | 0.089 | bioplex_WMM WMM_only |
| IL6ST | TRPM3 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| C5orf22 | TRPM3 | 0.008 | 0.061 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06859 has an average edge precision of 0.275 which is ranked 4949 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TRPM3 | HuMAP2_05323 HuMAP2_06859 |
| C5orf22 | HuMAP2_00903 HuMAP2_04133 HuMAP2_05046 HuMAP2_06439 HuMAP2_06859 HuMAP2_06954 |
| OSM | HuMAP2_00432 HuMAP2_05323 HuMAP2_05755 HuMAP2_06859 |
| IL6ST | HuMAP2_00432 HuMAP2_05323 HuMAP2_06859 |