hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06862
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SIGLEC5 | Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170) | UniProt NCBI |
| PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) | UniProt NCBI |
| RBP1 | Retinol-binding protein 1 (Cellular retinol-binding protein) (CRBP) (Cellular retinol-binding protein I) (CRBP-I) | UniProt NCBI |
| MAPKAPK2 | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) | UniProt NCBI |
| NECAP1 | Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1) | UniProt NCBI |
| GAMT | Guanidinoacetate N-methyltransferase (EC 2.1.1.2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP195 | 0.0070633221054 | 0.333333333333 | MAPKAPK2 PTPN11 | IL-1 signaling pathway |
| KEGG:04625 | 0.0236020276363 | 0.333333333333 | MAPKAPK2 PTPN11 | C-type lectin receptor signaling pathway |
| KEGG:04722 | 0.0348461971614 | 0.333333333333 | MAPKAPK2 PTPN11 | Neurotrophin signaling pathway |
| CORUM:3183 | 0.0499726005494 | 0.166666666667 | PTPN11 | PDGFRA-SHP-2 complex, PDGF stimulated |
| CORUM:3186 | 0.0499726005494 | 0.166666666667 | PTPN11 | GRB2-SHP-2 complex, PDGF stimulated |
| CORUM:7441 | 0.0499726005494 | 0.166666666667 | PTPN11 | HOOK1-SHP2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RBP1 | PTPN11 | 0.07 | 0.35 | fraction |
| NECAP1 | PTPN11 | 0.051 | 0.296 | fraction |
| RBP1 | GAMT | 0.033 | 0.256 | fraction |
| PTPN11 | SIGLEC5 | 0.022 | 0.21 | bioplex (SIGLEC5) bioplex_WMM |
| MAPKAPK2 | PTPN11 | 0.021 | 0.192 | youn_WMM fraction |
| GAMT | PTPN11 | 0.007 | 0.002 | WMM_only bioplex_WMM |
| RBP1 | NECAP1 | 0.003 | 0.01 | fraction |
| MAPKAPK2 | NECAP1 | 0.0 | 0.008 | fraction |
| GAMT | NECAP1 | 0.0 | 0.0 | fraction |
Images
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Complex HuMAP2_06862 has an average edge precision of 0.147 which is ranked 6721 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SIGLEC5 | HuMAP2_06862 |
| PTPN11 | HuMAP2_04051 HuMAP2_05641 HuMAP2_06862 |
| RBP1 | HuMAP2_00009 HuMAP2_01180 HuMAP2_02116 HuMAP2_04051 HuMAP2_06862 |
| MAPKAPK2 | HuMAP2_00140 HuMAP2_04988 HuMAP2_05232 HuMAP2_05959 HuMAP2_06862 |
| NECAP1 | HuMAP2_01015 HuMAP2_02529 HuMAP2_03623 HuMAP2_05052 HuMAP2_06862 |
| GAMT | HuMAP2_00009 HuMAP2_01180 HuMAP2_02116 HuMAP2_04839 HuMAP2_06862 |