hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06870
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | UniProt NCBI |
| EEF1AKNMT | eEF1A lysine and N-terminal methyltransferase (eEF1A-KNMT) (Methyltransferase-like protein 13) [Includes: eEF1A lysine methyltransferase (EC 2.1.1.-); eEF1A N-terminal methyltransferase (EC 2.1.1.-)] | UniProt NCBI |
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | UniProt NCBI |
| USP8 | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065678 | 4.19788236367e-11 | 0.666666666667 | SUMO2 SAE1 UBE2I UBA2 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 2.51791739053e-10 | 0.666666666667 | SUMO2 SAE1 UBE2I UBA2 | Processing and activation of SUMO |
| REAC:R-HSA-3065676 | 5.95351688467e-08 | 0.5 | SUMO2 SAE1 UBA2 | SUMO is conjugated to E1 (UBA2:SAE1) |
| CORUM:5756 | 8.39001385941e-06 | 0.333333333333 | SAE1 UBA2 | SUA1-UBA2 complex |
| GO:0044388 | 1.81582264982e-05 | 0.5 | SAE1 UBE2I UBA2 | small protein activating enzyme binding |
| CORUM:5755 | 2.51655344529e-05 | 0.333333333333 | SAE1 UBA2 | SUMO1-SUA1-UBA2 complex |
| REAC:R-HSA-2990846 | 4.14836354799e-05 | 0.666666666667 | SUMO2 SAE1 UBE2I UBA2 | SUMOylation |
| GO:0016925 | 0.000314144203038 | 0.666666666667 | SUMO2 SAE1 UBE2I UBA2 | protein sumoylation |
| KEGG:04120 | 0.000590221771159 | 0.5 | SAE1 UBE2I UBA2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-196791 | 0.000996295422965 | 0.333333333333 | UBE2I SUMO2 | Vitamin D (calciferol) metabolism |
| REAC:R-HSA-3232118 | 0.0030072528049 | 0.333333333333 | UBE2I SUMO2 | SUMOylation of transcription factors |
| REAC:R-HSA-597592 | 0.00391856777133 | 0.833333333333 | USP8 SUMO2 SAE1 UBE2I UBA2 | Post-translational protein modification |
| REAC:R-HSA-4090294 | 0.0055883638448 | 0.333333333333 | UBE2I SUMO2 | SUMOylation of intracellular receptors |
| GO:0019948 | 0.00676235117068 | 0.333333333333 | SAE1 UBA2 | SUMO activating enzyme activity |
| REAC:R-HSA-4085377 | 0.0102563889288 | 0.333333333333 | UBE2I SUMO2 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3899300 | 0.0171765331493 | 0.333333333333 | UBE2I SUMO2 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 0.0189534530409 | 0.333333333333 | UBE2I SUMO2 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4615885 | 0.0189534530409 | 0.333333333333 | UBE2I SUMO2 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-5696395 | 0.019874448248 | 0.333333333333 | UBE2I SUMO2 | Formation of Incision Complex in GG-NER |
| GO:0031510 | 0.020283420769 | 0.333333333333 | SAE1 UBA2 | SUMO activating enzyme complex |
| REAC:R-HSA-392499 | 0.0232605972232 | 0.833333333333 | USP8 SUMO2 SAE1 UBE2I UBA2 | Metabolism of proteins |
| REAC:R-HSA-4551638 | 0.0455991929544 | 0.333333333333 | UBE2I SUMO2 | SUMOylation of chromatin organization proteins |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SAE1 | UBA2 | 0.988 | 0.901 | hein_WMM bioplex (UBA2) bioplex_WMM Guru youn_WMM hein (SAE1) gupta_WMM fraction |
| SAE1 | SUMO2 | 0.605 | 0.672 | hein_WMM bioplex_WMM youn_WMM hein (SAE1) gupta_WMM fraction |
| UBE2I | SUMO2 | 0.574 | 0.656 | hein_WMM bioplex (UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| UBE2I | UBA2 | 0.533 | 0.638 | hein_WMM bioplex (UBA2,UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| SAE1 | EEF1AKNMT | 0.179 | 0.438 | bioplex_WMM fraction |
| UBE2I | USP8 | 0.079 | 0.351 | youn_WMM gupta_WMM fraction |
| UBE2I | SAE1 | 0.07 | 0.35 | hein_WMM bioplex (UBE2I) bioplex_WMM Guru youn_WMM hein (UBE2I) gupta_WMM fraction |
| SUMO2 | UBA2 | 0.009 | 0.093 | hein_WMM bioplex (UBA2) bioplex_WMM youn_WMM gupta_WMM |
| UBE2I | EEF1AKNMT | 0.007 | 0.001 | gupta_WMM WMM_only |
| SUMO2 | EEF1AKNMT | 0.007 | 0.0 | bioplex_WMM WMM_only |
| EEF1AKNMT | UBA2 | 0.004 | 0.012 | fraction |
| SUMO2 | USP8 | 0.003 | 0.015 | gupta_WMM fraction |
| SAE1 | USP8 | 0.0 | 0.002 | fraction |
Images
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Complex HuMAP2_06870 has an average edge precision of 0.318 which is ranked 4378 out of all 6965 complexes.
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