hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06875
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NFKBIA | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) | UniProt NCBI |
| RELA | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5475 | 5.02777038712e-06 | 1.0 | RELA NFKBIA | MURR1-NF(kappa)Bp65-IKBA complex |
| CORUM:5492 | 5.02777038712e-06 | 1.0 | RELA NFKBIA | IKBA-p50-p65 Nf(kappa)B complex |
| CORUM:5467 | 5.02777038712e-06 | 1.0 | RELA NFKBIA | IKB(alpha)-RELA-cREL complex |
| CORUM:5464 | 5.02777038712e-06 | 1.0 | RELA NFKBIA | IKBA-p50-p65 Nf(kappa)B complex |
| WP:WP4562 | 1.04322772881e-05 | 1.0 | RELA NFKBIA | Canonical NF-KB pathway |
| WP:WP4479 | 1.04322772881e-05 | 1.0 | RELA NFKBIA | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP4480 | 1.34129279418e-05 | 1.0 | RELA NFKBIA | Role Altered Glycolysation of MUC1 in Tumour Microenvironment |
| CORUM:2105 | 2.51388519356e-05 | 1.0 | RELA NFKBIA | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| REAC:R-HSA-5603029 | 3.51943927099e-05 | 1.0 | RELA NFKBIA | IkBA variant leads to EDA-ID |
| WP:WP262 | 7.82420796608e-05 | 1.0 | RELA NFKBIA | EBV LMP1 signaling |
| WP:WP4482 | 7.82420796608e-05 | 1.0 | RELA NFKBIA | Vitamin D in inflammatory diseases |
| REAC:R-HSA-209560 | 9.21757904306e-05 | 1.0 | RELA NFKBIA | NF-kB is activated and signals survival |
| REAC:R-HSA-4755510 | 9.21757904306e-05 | 1.0 | RELA NFKBIA | SUMOylation of immune response proteins |
| CORUM:5193 | 0.000110610948517 | 1.0 | RELA NFKBIA | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5230 | 0.000110610948517 | 1.0 | RELA NFKBIA | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| KEGG:05134 | 0.00015100395818 | 1.0 | RELA NFKBIA | Legionellosis |
| WP:WP4496 | 0.000151268020678 | 1.0 | RELA NFKBIA | Signal transduction through IL1R |
| REAC:R-HSA-193639 | 0.000152509035076 | 1.0 | RELA NFKBIA | p75NTR signals via NF-kB |
| WP:WP4329 | 0.000162072879297 | 1.0 | RELA NFKBIA | miRNAs involvement in the immune response in sepsis |
| WP:WP3414 | 0.000162072879297 | 1.0 | RELA NFKBIA | Initiation of transcription and translation elongation at the HIV-1 LTR |
| WP:WP4481 | 0.000162072879297 | 1.0 | RELA NFKBIA | Resistin as a regulator of inflammation |
| REAC:R-HSA-1810476 | 0.000227925590883 | 1.0 | RELA NFKBIA | RIP-mediated NFkB activation via ZBP1 |
| CORUM:5232 | 0.000227925590883 | 1.0 | RELA NFKBIA | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| KEGG:05140 | 0.00023285248044 | 1.0 | RELA NFKBIA | Leishmaniasis |
| KEGG:04623 | 0.000241168640456 | 1.0 | RELA NFKBIA | Cytosolic DNA-sensing pathway |
| WP:WP1433 | 0.000261924676198 | 1.0 | RELA NFKBIA | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| KEGG:05120 | 0.000266992505768 | 1.0 | RELA NFKBIA | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP2036 | 0.00029061343874 | 1.0 | RELA NFKBIA | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| KEGG:04920 | 0.000294129448977 | 1.0 | RELA NFKBIA | Adipocytokine signaling pathway |
| KEGG:04622 | 0.000294129448977 | 1.0 | RELA NFKBIA | RIG-I-like receptor signaling pathway |
| KEGG:05131 | 0.000294129448977 | 1.0 | RELA NFKBIA | Shigellosis |
| WP:WP2203 | 0.000305516692009 | 1.0 | RELA NFKBIA | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| KEGG:04662 | 0.000322579470084 | 1.0 | RELA NFKBIA | B cell receptor signaling pathway |
| WP:WP4008 | 0.000336440942541 | 1.0 | RELA NFKBIA | NO/cGMP/PKG mediated Neuroprotection |
| REAC:R-HSA-1606322 | 0.000351943927099 | 1.0 | RELA NFKBIA | ZBP1(DAI) mediated induction of type I IFNs |
| KEGG:04657 | 0.000352342569087 | 1.0 | RELA NFKBIA | IL-17 signaling pathway |
| KEGG:04658 | 0.000362555397177 | 1.0 | RELA NFKBIA | Th1 and Th2 cell differentiation |
| REAC:R-HSA-933542 | 0.000387138319809 | 1.0 | RELA NFKBIA | TRAF6 mediated NF-kB activation |
| KEGG:05220 | 0.00039406926671 | 1.0 | RELA NFKBIA | Chronic myeloid leukemia |
| REAC:R-HSA-5602358 | 0.000424008635981 | 1.0 | RELA NFKBIA | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.000424008635981 | 1.0 | RELA NFKBIA | Diseases of Immune System |
| WP:WP2637 | 0.0004381556461 | 1.0 | RELA NFKBIA | Structural Pathway of Interleukin 1 (IL-1) |
| KEGG:04064 | 0.000449510333482 | 1.0 | RELA NFKBIA | NF-kappa B signaling pathway |
| KEGG:05235 | 0.000461036239468 | 1.0 | RELA NFKBIA | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP195 | 0.00047504119794 | 1.0 | RELA NFKBIA | IL-1 signaling pathway |
| WP:WP395 | 0.000494042845858 | 1.0 | RELA NFKBIA | IL-4 Signaling Pathway |
| WP:WP2018 | 0.000494042845858 | 1.0 | RELA NFKBIA | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| WP:WP3865 | 0.000533163885688 | 1.0 | RELA NFKBIA | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:04620 | 0.000533255523815 | 1.0 | RELA NFKBIA | Toll-like receptor signaling pathway |
| KEGG:04659 | 0.000533255523815 | 1.0 | RELA NFKBIA | Th17 cell differentiation |
| KEGG:05142 | 0.000558495798951 | 1.0 | RELA NFKBIA | Chagas disease (American trypanosomiasis) |
| KEGG:04625 | 0.000558495798951 | 1.0 | RELA NFKBIA | C-type lectin receptor signaling pathway |
| KEGG:05215 | 0.000584319664263 | 1.0 | RELA NFKBIA | Prostate cancer |
| KEGG:04660 | 0.000584319664263 | 1.0 | RELA NFKBIA | T cell receptor signaling pathway |
| KEGG:05222 | 0.000610727119751 | 1.0 | RELA NFKBIA | Small cell lung cancer |
| KEGG:04668 | 0.000624149693812 | 1.0 | RELA NFKBIA | TNF signaling pathway |
| KEGG:05145 | 0.000637718165416 | 1.0 | RELA NFKBIA | Toxoplasmosis |
| REAC:R-HSA-445989 | 0.000729026706133 | 1.0 | RELA NFKBIA | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| WP:WP2374 | 0.000751123964743 | 1.0 | RELA NFKBIA | Oncostatin M Signaling Pathway |
| KEGG:04931 | 0.000751518249842 | 1.0 | RELA NFKBIA | Insulin resistance |
| KEGG:04380 | 0.000766399799344 | 1.0 | RELA NFKBIA | Osteoclast differentiation |
| WP:WP3303 | 0.000774969169973 | 1.0 | RELA NFKBIA | RAC1/PAK1/p38/MMP2 Pathway |
| WP:WP2324 | 0.000774969169973 | 1.0 | RELA NFKBIA | AGE/RAGE pathway |
| KEGG:04722 | 0.000827384972793 | 1.0 | RELA NFKBIA | Neurotrophin signaling pathway |
| WP:WP4655 | 0.000848740273654 | 1.0 | RELA NFKBIA | Cytosolic DNA-sensing pathway |
| KEGG:05135 | 0.000906899134346 | 1.0 | RELA NFKBIA | Yersinia infection |
| WP:WP254 | 0.000979143739755 | 1.0 | RELA NFKBIA | Apoptosis |
| WP:WP2037 | 0.00100634217697 | 1.0 | RELA NFKBIA | Prolactin Signaling Pathway |
| KEGG:04926 | 0.00104170846513 | 1.0 | RELA NFKBIA | Relaxin signaling pathway |
| WP:WP69 | 0.00109017297661 | 1.0 | RELA NFKBIA | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:04210 | 0.00113070596705 | 1.0 | RELA NFKBIA | Apoptosis |
| KEGG:05162 | 0.00118585523873 | 1.0 | RELA NFKBIA | Measles |
| KEGG:04062 | 0.00122335090758 | 1.0 | RELA NFKBIA | Chemokine signaling pathway |
| WP:WP2355 | 0.00129881852237 | 1.0 | RELA NFKBIA | Corticotropin-releasing hormone signaling pathway |
| KEGG:05160 | 0.00133933945516 | 1.0 | RELA NFKBIA | Hepatitis C |
| WP:WP23 | 0.00142624133782 | 1.0 | RELA NFKBIA | B Cell Receptor Signaling Pathway |
| WP:WP75 | 0.00142624133782 | 1.0 | RELA NFKBIA | Toll-like Receptor Signaling Pathway |
| KEGG:05164 | 0.00158707348511 | 1.0 | RELA NFKBIA | Influenza A |
| WP:WP4658 | 0.00166357564612 | 1.0 | RELA NFKBIA | Small cell lung cancer |
| KEGG:05161 | 0.00174128718926 | 1.0 | RELA NFKBIA | Hepatitis B |
| KEGG:04621 | 0.00180956723991 | 1.0 | RELA NFKBIA | NOD-like receptor signaling pathway |
| KEGG:05167 | 0.00197399377215 | 1.0 | RELA NFKBIA | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04024 | 0.00209581822151 | 1.0 | RELA NFKBIA | cAMP signaling pathway |
| KEGG:05130 | 0.00227250014745 | 1.0 | RELA NFKBIA | Pathogenic Escherichia coli infection |
| KEGG:05169 | 0.00242963180249 | 1.0 | RELA NFKBIA | Epstein-Barr virus infection |
| KEGG:05203 | 0.00256458703081 | 1.0 | RELA NFKBIA | Viral carcinogenesis |
| WP:WP1449 | 0.00257192893285 | 1.0 | RELA NFKBIA | Regulation of toll-like receptor signaling pathway |
| KEGG:05166 | 0.00281669798708 | 1.0 | RELA NFKBIA | Human T-cell leukemia virus 1 infection |
| WP:WP3929 | 0.00284130523568 | 1.0 | RELA NFKBIA | Chemokine signaling pathway |
| KEGG:05170 | 0.00287432751701 | 1.0 | RELA NFKBIA | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0029618660435 | 1.0 | RELA NFKBIA | Human cytomegalovirus infection |
| REAC:R-HSA-1834949 | 0.00327307852202 | 1.0 | RELA NFKBIA | Cytosolic sensors of pathogen-associated DNA |
| WP:WP2380 | 0.00342029662517 | 1.0 | RELA NFKBIA | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-1169091 | 0.00359485582679 | 1.0 | RELA NFKBIA | Activation of NF-kappaB in B cells |
| REAC:R-HSA-168928 | 0.00428366036983 | 1.0 | RELA NFKBIA | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| REAC:R-HSA-2871837 | 0.00477638186777 | 1.0 | RELA NFKBIA | FCERI mediated NF-kB activation |
| REAC:R-HSA-1168372 | 0.00490375205091 | 1.0 | RELA NFKBIA | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-975871 | 0.00556574181855 | 1.0 | RELA NFKBIA | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.00556574181855 | 1.0 | RELA NFKBIA | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 0.00556574181855 | 1.0 | RELA NFKBIA | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975138 | 0.00584226918984 | 1.0 | RELA NFKBIA | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.00598304676068 | 1.0 | RELA NFKBIA | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.00598304676068 | 1.0 | RELA NFKBIA | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-193704 | 0.00612550025498 | 1.0 | RELA NFKBIA | p75 NTR receptor-mediated signalling |
| REAC:R-HSA-202424 | 0.00656291627866 | 1.0 | RELA NFKBIA | Downstream TCR signaling |
| REAC:R-HSA-168188 | 0.00656291627866 | 1.0 | RELA NFKBIA | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00656291627866 | 1.0 | RELA NFKBIA | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168138 | 0.00656291627866 | 1.0 | RELA NFKBIA | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00671207346681 | 1.0 | RELA NFKBIA | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-168179 | 0.0070154156135 | 1.0 | RELA NFKBIA | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-5607764 | 0.0070154156135 | 1.0 | RELA NFKBIA | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-181438 | 0.0070154156135 | 1.0 | RELA NFKBIA | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-166166 | 0.00716960057204 | 1.0 | RELA NFKBIA | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.00716960057204 | 1.0 | RELA NFKBIA | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-9020702 | 0.00780309964082 | 1.0 | RELA NFKBIA | Interleukin-1 signaling |
| REAC:R-HSA-983705 | 0.00846341348499 | 1.0 | RELA NFKBIA | Signaling by the B Cell Receptor (BCR) |
| WP:WP3888 | 0.00889388896944 | 1.0 | RELA NFKBIA | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-202403 | 0.00950416195513 | 1.0 | RELA NFKBIA | TCR signaling |
| KEGG:05168 | 0.010450786984 | 1.0 | RELA NFKBIA | Herpes simplex virus 1 infection |
| REAC:R-HSA-166016 | 0.0115688996608 | 1.0 | RELA NFKBIA | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-2454202 | 0.0119660935214 | 1.0 | RELA NFKBIA | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-446652 | 0.0131978972662 | 1.0 | RELA NFKBIA | Interleukin-1 family signaling |
| REAC:R-HSA-73887 | 0.0131978972662 | 1.0 | RELA NFKBIA | Death Receptor Signalling |
| REAC:R-HSA-5621481 | 0.0131978972662 | 1.0 | RELA NFKBIA | C-type lectin receptors (CLRs) |
| KEGG:05200 | 0.0157394270613 | 1.0 | RELA NFKBIA | Pathways in cancer |
| REAC:R-HSA-168898 | 0.0163067352889 | 1.0 | RELA NFKBIA | Toll-like Receptor Cascades |
| REAC:R-HSA-3108232 | 0.0229517718172 | 1.0 | RELA NFKBIA | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0246461304377 | 1.0 | RELA NFKBIA | SUMOylation |
| WP:WP3926 | 0.038834152205 | 0.5 | RELA | ApoE and miR-146 in inflammation and atherosclerosis |
| WP:WP288 | 0.0443803979089 | 0.5 | RELA | NLR Proteins |
| HP:0011114 | 0.0497341708567 | 0.5 | NFKBIA | Defective production of NFKB1-dependent cytokines |
| HP:0011113 | 0.0497341708567 | 0.5 | NFKBIA | Abnormality of cytokine secretion |
| CORUM:7317 | 0.0499173803268 | 0.5 | RELA | RELA-STAT3 complex |
| CORUM:5460 | 0.0499173803268 | 0.5 | RELA | p50-p65 NF(kappa)B complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFKBIA | RELA | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA) bioplex_WMM hein (NFKBIA) |
Images
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Complex HuMAP2_06875 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NFKBIA | HuMAP2_01917 HuMAP2_02654 HuMAP2_03076 HuMAP2_03080 HuMAP2_06875 |
| RELA | HuMAP2_01917 HuMAP2_03076 HuMAP2_06875 |