hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06880

Confidence: Medium High

Genename	Protein Name	Links
TLE5	TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)	UniProt NCBI
TLE4	Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)	UniProt NCBI
RIPPLY2	Protein ripply2	UniProt NCBI
RIPPLY3	Protein ripply3 (Down syndrome critical region protein 6)	UniProt NCBI
TLE2	Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)	UniProt NCBI
TLE1	Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)	UniProt NCBI
RIPPLY1	Protein ripply1	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-4641265	1.41173351619e-09	0.571428571429	TLE1 TLE2 TLE5 TLE4	Repression of WNT target genes
REAC:R-HSA-195253	4.93220962918e-06	0.571428571429	TLE1 TLE2 TLE5 TLE4	Degradation of beta-catenin by the destruction complex
CORUM:3124	1.007158685e-05	0.285714285714	TLE1 TLE2	TLE1-TLE2 complex
REAC:R-HSA-3769402	9.645347366e-05	0.428571428571	TLE1 TLE2 TLE4	Deactivation of the beta-catenin transactivating complex
REAC:R-HSA-2122947	0.000130142457859	0.428571428571	TLE1 TLE2 TLE4	NOTCH1 Intracellular Domain Regulates Transcription
REAC:R-HSA-1980143	0.000437510353479	0.428571428571	TLE1 TLE2 TLE4	Signaling by NOTCH1
GO:0070491	0.000441502177302	0.571428571429	TLE1 TLE2 TLE5 TLE4	repressing transcription factor binding
REAC:R-HSA-195721	0.00102546654483	0.571428571429	TLE1 TLE2 TLE5 TLE4	Signaling by WNT
REAC:R-HSA-201722	0.00118651715165	0.428571428571	TLE1 TLE2 TLE4	Formation of the beta-catenin:TCF transactivating complex
GO:0009880	0.00421229492459	0.428571428571	RIPPLY3 RIPPLY2 RIPPLY1	embryonic pattern specification
GO:0032525	0.00946729163895	0.285714285714	RIPPLY2 RIPPLY1	somite rostral/caudal axis specification
GO:0045892	0.0126459869113	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of transcription, DNA-templated
GO:1903507	0.012821195374	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of nucleic acid-templated transcription
GO:1904837	0.0128352677703	0.428571428571	TLE1 TLE2 TLE4	beta-catenin-TCF complex assembly
GO:1902679	0.0129095525265	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of RNA biosynthetic process
GO:0090090	0.0135557748337	0.571428571429	TLE1 TLE2 TLE5 TLE4	negative regulation of canonical Wnt signaling pathway
REAC:R-HSA-157118	0.01781034888	0.428571428571	TLE1 TLE2 TLE4	Signaling by NOTCH
REAC:R-HSA-201681	0.0182953414124	0.428571428571	TLE1 TLE2 TLE4	TCF dependent signaling in response to WNT
GO:0051253	0.0212806302754	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of RNA metabolic process
GO:0030178	0.0224457600324	0.571428571429	TLE1 TLE2 TLE5 TLE4	negative regulation of Wnt signaling pathway
CORUM:3127	0.0249993571594	0.142857142857	TLE1	TLE-Histone H3 complex
CORUM:3125	0.0249993571594	0.142857142857	TLE1	TLE1 homodimer complex
CORUM:3123	0.0249993571594	0.142857142857	TLE2	TLE2 homodimer complex
GO:0045934	0.0331468774122	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of nucleobase-containing compound metabolic process
GO:2000113	0.0333411679743	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of cellular macromolecule biosynthetic process
GO:0010558	0.0367915341449	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of macromolecule biosynthetic process
GO:0031327	0.0443376193359	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of cellular biosynthetic process
GO:0009890	0.0476427474477	0.857142857143	RIPPLY3 TLE2 TLE5 RIPPLY2 TLE1 RIPPLY1	negative regulation of biosynthetic process
CORUM:3164	0.0499886427319	0.142857142857	TLE1	HESX1-TLE1 complex
CORUM:3150	0.0499886427319	0.142857142857	TLE1	NK-3-Groucho complex
CORUM:3121	0.0499886427319	0.142857142857	TLE4	OCT2-TLE4 complex
CORUM:6769	0.0499886427319	0.142857142857	TLE1	TBX20-TLE1 repressor complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TLE4	TLE2	1.0	0.949	bioplex (TLE4) bioplex_WMM
TLE5	TLE4	0.994	0.923	bioplex (TLE4) bioplex_WMM youn_WMM
TLE1	TLE4	0.98	0.896	bioplex (TLE4) bioplex_WMM youn_WMM
TLE2	RIPPLY1	0.662	0.698	bioplex (RIPPLY1) bioplex_WMM
TLE2	RIPPLY2	0.568	0.655	bioplex (RIPPLY2) bioplex_WMM
TLE4	RIPPLY3	0.489	0.617	bioplex (TLE4) bioplex_WMM
TLE4	RIPPLY1	0.47	0.605	bioplex (RIPPLY1) bioplex_WMM
TLE4	RIPPLY2	0.383	0.55	bioplex (RIPPLY2) bioplex_WMM
TLE5	RIPPLY2	0.099	0.359	bioplex (RIPPLY2) bioplex_WMM
TLE1	RIPPLY1	0.067	0.351	bioplex (RIPPLY1) bioplex_WMM
TLE1	RIPPLY2	0.063	0.347	bioplex (RIPPLY2) bioplex_WMM
TLE5	RIPPLY1	0.018	0.18	bioplex (RIPPLY1) bioplex_WMM
TLE1	TLE2	0.017	0.175	bioplex_WMM WMM_only
TLE1	TLE5	0.012	0.146	bioplex_WMM youn_WMM WMM_only
TLE5	TLE2	0.011	0.14	bioplex_WMM WMM_only
TLE5	RIPPLY3	0.008	0.087	bioplex_WMM WMM_only
TLE1	RIPPLY3	0.008	0.081	bioplex_WMM WMM_only
TLE2	RIPPLY3	0.008	0.082	bioplex_WMM WMM_only

Images

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Complex HuMAP2_06880 has an average edge precision of 0.436 which is ranked 2973 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TLE5	HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880
TLE4	HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880
RIPPLY2	HuMAP2_04314 HuMAP2_05545 HuMAP2_06880
RIPPLY3	HuMAP2_05545 HuMAP2_06880
TLE2	HuMAP2_04314 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880
TLE1	HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880
RIPPLY1	HuMAP2_04314 HuMAP2_05545 HuMAP2_06880

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_06880