hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06895
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SRRM2 | Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) | UniProt NCBI |
| CLASRP | CLK4-associating serine/arginine rich protein (Splicing factor, arginine/serine-rich 16) (Suppressor of white-apricot homolog 2) | UniProt NCBI |
| LUC7L2 | Putative RNA-binding protein Luc7-like 2 | UniProt NCBI |
| PNN | Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein) | UniProt NCBI |
| CWC22 | Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb) | UniProt NCBI |
| GPATCH8 | G patch domain-containing protein 8 | UniProt NCBI |
| ACIN1 | Apoptotic chromatin condensation inducer in the nucleus (Acinus) | UniProt NCBI |
| ZC3H18 | Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1) | UniProt NCBI |
| SAP18 | Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18) | UniProt NCBI |
| RNPS1 | RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2) | UniProt NCBI |
| SNIP1 | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | UniProt NCBI |
| ZC3H14 | Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37) | UniProt NCBI |
| CCDC9 | Coiled-coil domain-containing protein 9 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:760 | 2.97527064635e-08 | 0.230769230769 | SAP18 ACIN1 RNPS1 | Apoptosis- and splicing-associated protein complex (ASAP-L), SAP18, RNPS1, Acinus-L |
| GO:0003723 | 3.45957724408e-07 | 0.923076923077 | SAP18 ACIN1 CCDC9 SNIP1 PNN LUC7L2 ZC3H14 RNPS1 SRRM2 GPATCH8 CWC22 ZC3H18 | RNA binding |
| GO:0016607 | 1.14095759914e-06 | 0.615384615385 | SAP18 ACIN1 PNN LUC7L2 ZC3H14 SRRM2 CWC22 ZC3H18 | nuclear speck |
| GO:0006397 | 1.3881900975e-05 | 0.615384615385 | SAP18 SNIP1 PNN LUC7L2 ZC3H14 RNPS1 SRRM2 CWC22 | mRNA processing |
| KEGG:03015 | 3.98093727555e-05 | 0.307692307692 | SAP18 ACIN1 PNN RNPS1 | mRNA surveillance pathway |
| GO:0061574 | 0.000103844122491 | 0.230769230769 | SAP18 ACIN1 RNPS1 | ASAP complex |
| GO:0000377 | 0.000127513703343 | 0.538461538462 | SAP18 SNIP1 LUC7L2 PNN RNPS1 SRRM2 CWC22 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000127513703343 | 0.538461538462 | SAP18 SNIP1 LUC7L2 PNN RNPS1 SRRM2 CWC22 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000136289879607 | 0.538461538462 | SAP18 SNIP1 LUC7L2 PNN RNPS1 SRRM2 CWC22 | RNA splicing, via transesterification reactions |
| CORUM:351 | 0.000286746311149 | 0.307692307692 | SRRM2 ACIN1 CWC22 RNPS1 | Spliceosome |
| GO:0003676 | 0.000304028222362 | 0.923076923077 | SAP18 ACIN1 CCDC9 SNIP1 PNN LUC7L2 ZC3H14 RNPS1 SRRM2 GPATCH8 CWC22 ZC3H18 | nucleic acid binding |
| KEGG:03013 | 0.000363044020725 | 0.307692307692 | SAP18 ACIN1 PNN RNPS1 | RNA transport |
| GO:0016604 | 0.000390517379303 | 0.615384615385 | SAP18 ACIN1 PNN LUC7L2 ZC3H14 SRRM2 CWC22 ZC3H18 | nuclear body |
| GO:0008380 | 0.000416371439784 | 0.538461538462 | SAP18 SNIP1 LUC7L2 PNN RNPS1 SRRM2 CWC22 | RNA splicing |
| GO:0016071 | 0.00137903597169 | 0.615384615385 | SAP18 SNIP1 PNN LUC7L2 ZC3H14 RNPS1 SRRM2 CWC22 | mRNA metabolic process |
| CORUM:1181 | 0.00217947875338 | 0.230769230769 | SRRM2 PNN CWC22 | C complex spliceosome |
| GO:0006396 | 0.00256523565257 | 0.615384615385 | SAP18 SNIP1 PNN LUC7L2 ZC3H14 RNPS1 SRRM2 CWC22 | RNA processing |
| GO:1901363 | 0.00415485262788 | 0.923076923077 | SAP18 ACIN1 CCDC9 SNIP1 PNN LUC7L2 ZC3H14 RNPS1 SRRM2 GPATCH8 CWC22 ZC3H18 | heterocyclic compound binding |
| GO:0097159 | 0.00509355663611 | 0.923076923077 | SAP18 ACIN1 CCDC9 SNIP1 PNN LUC7L2 ZC3H14 RNPS1 SRRM2 GPATCH8 CWC22 ZC3H18 | organic cyclic compound binding |
| GO:0005681 | 0.00832214498963 | 0.384615384615 | CWC22 SNIP1 SRRM2 LUC7L2 PNN | spliceosomal complex |
| GO:0044451 | 0.00993658387497 | 0.615384615385 | SAP18 ACIN1 PNN LUC7L2 ZC3H14 SRRM2 CWC22 ZC3H18 | nucleoplasm part |
| GO:0035145 | 0.0249668240924 | 0.230769230769 | SAP18 PNN RNPS1 | exon-exon junction complex |
| HPA:007030_13 | 0.0319561906892 | 0.307692307692 | SRRM2 ACIN1 PNN SAP18 | cerebellum; cells in molecular layer[Supported,High] |
| HPA:007010_13 | 0.0354483890446 | 0.307692307692 | SRRM2 ACIN1 PNN SAP18 | cerebellum; Purkinje cells[Supported,High] |
| GO:0050686 | 0.039619012417 | 0.230769230769 | SAP18 ZC3H14 RNPS1 | negative regulation of mRNA processing |
| GO:0005684 | 0.0446950625718 | 0.307692307692 | CWC22 SNIP1 LUC7L2 SRRM2 | U2-type spliceosomal complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RNPS1 | SRRM2 | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| ACIN1 | PNN | 0.999 | 0.949 | hein_WMM bioplex (PNN) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| RNPS1 | ACIN1 | 0.997 | 0.931 | bioplex_WMM youn_WMM gupta_WMM fraction |
| RNPS1 | PNN | 0.994 | 0.923 | bioplex (PNN) bioplex_WMM youn_WMM gupta_WMM fraction |
| CCDC9 | PNN | 0.986 | 0.901 | hein_WMM bioplex (PNN) bioplex_WMM youn_WMM hein (CCDC9) |
| GPATCH8 | LUC7L2 | 0.77 | 0.749 | bioplex (LUC7L2) bioplex_WMM youn_WMM gupta_WMM |
| ACIN1 | SRRM2 | 0.749 | 0.743 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| GPATCH8 | RNPS1 | 0.746 | 0.741 | bioplex_WMM youn_WMM hein (RNPS1) gupta_WMM fraction |
| ACIN1 | SNIP1 | 0.659 | 0.696 | bioplex (SNIP1) bioplex_WMM |
| CCDC9 | ACIN1 | 0.63 | 0.681 | hein_WMM bioplex_WMM youn_WMM hein (CCDC9) |
| CLASRP | LUC7L2 | 0.541 | 0.641 | bioplex (CLASRP,LUC7L2) bioplex_WMM youn_WMM |
| ZC3H14 | PNN | 0.441 | 0.584 | bioplex (PNN) bioplex_WMM youn_WMM gupta_WMM |
| SNIP1 | CLASRP | 0.421 | 0.573 | bioplex (SNIP1) bioplex_WMM |
| ZC3H18 | RNPS1 | 0.389 | 0.551 | bioplex (ZC3H18) bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| ACIN1 | LUC7L2 | 0.338 | 0.527 | bioplex (LUC7L2) bioplex_WMM youn_WMM gupta_WMM |
| RNPS1 | SNIP1 | 0.286 | 0.489 | bioplex (SNIP1) bioplex_WMM |
| SAP18 | CCDC9 | 0.278 | 0.486 | hein_WMM bioplex_WMM youn_WMM hein (CCDC9) |
| ZC3H18 | SRRM2 | 0.238 | 0.47 | bioplex (ZC3H18) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RNPS1 | LUC7L2 | 0.232 | 0.47 | bioplex (LUC7L2) bioplex_WMM youn_WMM gupta_WMM |
| SRRM2 | CWC22 | 0.205 | 0.453 | bioplex_WMM Guru youn_WMM fraction boldt_WMM treiber_WMM |
| SNIP1 | ZC3H14 | 0.137 | 0.408 | bioplex (SNIP1) bioplex_WMM |
| ZC3H14 | LUC7L2 | 0.113 | 0.381 | bioplex (LUC7L2) bioplex_WMM youn_WMM gupta_WMM |
| ZC3H18 | LUC7L2 | 0.109 | 0.377 | bioplex (LUC7L2,ZC3H18) bioplex_WMM youn_WMM gupta_WMM |
| SRRM2 | PNN | 0.108 | 0.373 | bioplex (PNN) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| ZC3H18 | ACIN1 | 0.099 | 0.358 | bioplex (ZC3H18) bioplex_WMM youn_WMM gupta_WMM fraction |
| ZC3H18 | CWC22 | 0.07 | 0.347 | bioplex_WMM youn_WMM fraction |
| CCDC9 | LUC7L2 | 0.062 | 0.341 | bioplex (LUC7L2) bioplex_WMM youn_WMM |
| ZC3H18 | PNN | 0.047 | 0.293 | bioplex (ZC3H18) bioplex_WMM youn_WMM gupta_WMM fraction |
| SNIP1 | PNN | 0.039 | 0.266 | bioplex (SNIP1) bioplex_WMM |
| CCDC9 | SNIP1 | 0.032 | 0.241 | bioplex (SNIP1) bioplex_WMM |
| ZC3H18 | ZC3H14 | 0.029 | 0.234 | bioplex (ZC3H18) bioplex_WMM youn_WMM |
| CWC22 | PNN | 0.029 | 0.231 | bioplex_WMM youn_WMM fraction treiber_WMM |
| RNPS1 | ZC3H14 | 0.022 | 0.196 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CCDC9 | ZC3H14 | 0.019 | 0.182 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GPATCH8 | CLASRP | 0.017 | 0.167 | bioplex_WMM youn_WMM WMM_only boldt_WMM |
| PNN | LUC7L2 | 0.016 | 0.164 | bioplex (LUC7L2,PNN) bioplex_WMM youn_WMM gupta_WMM |
| ACIN1 | ZC3H14 | 0.016 | 0.164 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ACIN1 | CLASRP | 0.016 | 0.155 | bioplex_WMM youn_WMM WMM_only |
| SRRM2 | ZC3H14 | 0.014 | 0.135 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CCDC9 | RNPS1 | 0.012 | 0.145 | bioplex_WMM youn_WMM WMM_only |
| RNPS1 | CLASRP | 0.012 | 0.15 | bioplex_WMM youn_WMM WMM_only |
| GPATCH8 | PNN | 0.011 | 0.141 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SRRM2 | CLASRP | 0.011 | 0.139 | bioplex_WMM boldt youn_WMM boldt_WMM |
| CCDC9 | CLASRP | 0.01 | 0.132 | bioplex_WMM youn_WMM WMM_only |
| GPATCH8 | ZC3H14 | 0.01 | 0.13 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CCDC9 | SRRM2 | 0.01 | 0.103 | bioplex_WMM youn_WMM WMM_only |
| SAP18 | SNIP1 | 0.009 | 0.111 | bioplex (SNIP1) bioplex_WMM |
| ZC3H14 | CLASRP | 0.009 | 0.109 | bioplex_WMM youn_WMM WMM_only |
| ZC3H18 | CLASRP | 0.009 | 0.11 | bioplex_WMM boldt youn_WMM boldt_WMM |
| SAP18 | GPATCH8 | 0.009 | 0.098 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SAP18 | ZC3H14 | 0.008 | 0.09 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ZC3H18 | GPATCH8 | 0.008 | 0.084 | bioplex_WMM youn_WMM fraction boldt_WMM |
| CCDC9 | GPATCH8 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SAP18 | CLASRP | 0.008 | 0.025 | bioplex_WMM youn_WMM WMM_only |
| ACIN1 | CWC22 | 0.008 | 0.027 | bioplex_WMM youn_WMM fraction treiber_WMM |
| CCDC9 | CWC22 | 0.008 | 0.008 | bioplex_WMM WMM_only |
| CWC22 | CLASRP | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| CWC22 | ZC3H14 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| ZC3H18 | CCDC9 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| SAP18 | LUC7L2 | 0.007 | 0.006 | bioplex (LUC7L2) bioplex_WMM youn_WMM gupta_WMM |
| GPATCH8 | SRRM2 | 0.006 | 0.008 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| SNIP1 | LUC7L2 | 0.005 | 0.009 | bioplex (SNIP1) bioplex_WMM |
| GPATCH8 | ACIN1 | 0.005 | 0.013 | bioplex_WMM youn_WMM gupta_WMM fraction |
| PNN | CLASRP | 0.004 | 0.006 | bioplex_WMM youn_WMM fraction |
| SAP18 | RNPS1 | 0.003 | 0.013 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SAP18 | SRRM2 | 0.003 | 0.015 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SAP18 | CWC22 | 0.003 | 0.014 | bioplex_WMM youn_WMM fraction |
| SRRM2 | LUC7L2 | 0.0 | 0.018 | bioplex (LUC7L2) bioplex_WMM youn_WMM gupta_WMM |
| RNPS1 | CWC22 | 0.0 | 0.016 | bioplex_WMM youn_WMM fraction |
| SRRM2 | SNIP1 | 0.0 | 0.017 | bioplex (SNIP1) bioplex_WMM |
| SAP18 | ACIN1 | 0.0 | 0.007 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| GPATCH8 | CWC22 | 0.0 | 0.011 | bioplex_WMM youn_WMM fraction |
| GPATCH8 | SNIP1 | 0.0 | 0.012 | bioplex (SNIP1) bioplex_WMM |
| CWC22 | SNIP1 | 0.0 | 0.001 | bioplex (SNIP1) bioplex_WMM |
| ZC3H18 | SAP18 | 0.0 | 0.001 | bioplex (ZC3H18) bioplex_WMM youn_WMM gupta_WMM fraction |
| ZC3H18 | SNIP1 | 0.0 | 0.001 | hein_WMM bioplex (SNIP1) bioplex_WMM |
| SAP18 | PNN | 0.0 | 0.001 | hein_WMM bioplex (PNN) bioplex_WMM youn_WMM gupta_WMM fraction |
| CWC22 | LUC7L2 | 0.0 | 0.001 | bioplex (LUC7L2) bioplex_WMM boldt youn_WMM boldt_WMM |
Images
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Complex HuMAP2_06895 has an average edge precision of 0.261 which is ranked 5204 out of all 6965 complexes.
Related Complexes