hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06896
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NFYB | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | UniProt NCBI |
| PSMD4 | 26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein) | UniProt NCBI |
| NFYA | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | UniProt NCBI |
| NFYC | Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2) | UniProt NCBI |
| CCDC92 | Coiled-coil domain-containing protein 92 (Limkain beta-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4478 | 1.35146690511e-09 | 0.6 | NFYC NFYA NFYB | CBF-DNA complex |
| CORUM:4498 | 5.40532307664e-09 | 0.6 | NFYC NFYA NFYB | p32-CBF-DNA complex |
| REAC:R-HSA-381183 | 2.28267971382e-07 | 0.6 | NFYC NFYA NFYB | ATF6 (ATF6-alpha) activates chaperone genes |
| REAC:R-HSA-381033 | 4.48293159034e-07 | 0.6 | NFYC NFYA NFYB | ATF6 (ATF6-alpha) activates chaperones |
| REAC:R-HSA-9614657 | 1.23570409997e-06 | 0.6 | NFYC NFYA NFYB | FOXO-mediated transcription of cell death genes |
| GO:0016602 | 3.6323771075e-06 | 0.6 | NFYC NFYA NFYB | CCAAT-binding factor complex |
| REAC:R-HSA-380994 | 5.49186125546e-06 | 0.6 | NFYC NFYA NFYB | ATF4 activates genes in response to endoplasmic reticulum stress |
| REAC:R-HSA-381042 | 9.90965664735e-06 | 0.6 | NFYC NFYA NFYB | PERK regulates gene expression |
| KEGG:04612 | 2.13438745038e-05 | 0.6 | NFYC NFYA NFYB | Antigen processing and presentation |
| REAC:R-HSA-2426168 | 2.28576897279e-05 | 0.6 | NFYC NFYA NFYB | Activation of gene expression by SREBF (SREBP) |
| REAC:R-HSA-1655829 | 5.30427262701e-05 | 0.6 | NFYC NFYA NFYB | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| REAC:R-HSA-9614085 | 8.34369774361e-05 | 0.6 | NFYC NFYA NFYB | FOXO-mediated transcription |
| REAC:R-HSA-381119 | 0.000247826336378 | 0.6 | NFYC NFYA NFYB | Unfolded Protein Response (UPR) |
| KEGG:05152 | 0.00046980759615 | 0.6 | NFYC NFYA NFYB | Tuberculosis |
| REAC:R-HSA-1989781 | 0.000519144712976 | 0.6 | NFYC NFYA NFYB | PPARA activates gene expression |
| REAC:R-HSA-400206 | 0.000534065976599 | 0.6 | NFYC NFYA NFYB | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| REAC:R-HSA-8957322 | 0.000874143100407 | 0.6 | NFYC NFYA NFYB | Metabolism of steroids |
| GO:0106118 | 0.00826983957236 | 0.6 | NFYC NFYA NFYB | regulation of sterol biosynthetic process |
| GO:0045540 | 0.00826983957236 | 0.6 | NFYC NFYA NFYB | regulation of cholesterol biosynthetic process |
| GO:0090181 | 0.0156368617465 | 0.6 | NFYC NFYA NFYB | regulation of cholesterol metabolic process |
| REAC:R-HSA-212436 | 0.0163364711391 | 0.8 | PSMD4 NFYC NFYA NFYB | Generic Transcription Pathway |
| GO:1902930 | 0.0250406933376 | 0.6 | NFYC NFYA NFYB | regulation of alcohol biosynthetic process |
| GO:0006695 | 0.0250406933376 | 0.6 | NFYC NFYA NFYB | cholesterol biosynthetic process |
| REAC:R-HSA-73857 | 0.0251017869848 | 0.8 | PSMD4 NFYC NFYA NFYB | RNA Polymerase II Transcription |
| GO:1902653 | 0.0278679504637 | 0.6 | NFYC NFYA NFYB | secondary alcohol biosynthetic process |
| GO:0016126 | 0.0293579111372 | 0.6 | NFYC NFYA NFYB | sterol biosynthetic process |
| MIRNA:hsa-miR-221-3p | 0.0350515280025 | 0.6 | NFYC NFYA PSMD4 | hsa-miR-221-3p |
| GO:0050810 | 0.0376065209581 | 0.6 | NFYC NFYA NFYB | regulation of steroid biosynthetic process |
| REAC:R-HSA-74160 | 0.038571388232 | 0.8 | PSMD4 NFYC NFYA NFYB | Gene expression (Transcription) |
| GO:0062012 | 0.0402400813039 | 0.8 | PSMD4 NFYC NFYA NFYB | regulation of small molecule metabolic process |
| GO:0000980 | 0.0432266328844 | 0.6 | NFYC NFYA NFYB | RNA polymerase II distal enhancer sequence-specific DNA binding |
| CORUM:0000000 | 0.0474603483533 | 1.0 | CCDC92 NFYC PSMD4 NFYA NFYB | CORUM root |
| CORUM:6091 | 0.0499494897235 | 0.2 | NFYA | NF-YA-LaminA complex |
| CORUM:6519 | 0.0499494897235 | 0.2 | CCDC92 | CCDC92-CEP164 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFYB | NFYC | 1.0 | 0.949 | hein_WMM bioplex (NFYC) bioplex_WMM Guru hein (NFYB,NFYC) Malo fraction |
| NFYA | NFYC | 0.602 | 0.67 | hein_WMM bioplex (NFYA,NFYC) bioplex_WMM Guru hein (NFYA,NFYC) fraction |
| NFYA | NFYB | 0.228 | 0.468 | hein_WMM bioplex_WMM Guru hein (NFYA,NFYB) fraction |
| NFYC | PSMD4 | 0.056 | 0.314 | fraction |
| PSMD4 | CCDC92 | 0.034 | 0.264 | bioplex (CCDC92) bioplex_WMM |
| NFYB | PSMD4 | 0.028 | 0.232 | fraction |
| NFYA | PSMD4 | 0.007 | 0.0 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06896 has an average edge precision of 0.414 which is ranked 3164 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NFYB | HuMAP2_00188 HuMAP2_01706 HuMAP2_01774 HuMAP2_04445 HuMAP2_05672 HuMAP2_06896 |
| PSMD4 | HuMAP2_02473 HuMAP2_03019 HuMAP2_03449 HuMAP2_03722 HuMAP2_05073 HuMAP2_05387 HuMAP2_06896 |
| NFYA | HuMAP2_00188 HuMAP2_05672 HuMAP2_06480 HuMAP2_06896 |
| NFYC | HuMAP2_00188 HuMAP2_01774 HuMAP2_05672 HuMAP2_06896 |
| CCDC92 | HuMAP2_06791 HuMAP2_06896 |