hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06899
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LMNA | Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)] | UniProt NCBI |
| LMNB2 | Lamin-B2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0009002 | 1.00182980306e-05 | 1.0 | LMNA LMNB2 | Loss of truncal subcutaneous adipose tissue |
| HP:0000291 | 9.35041149526e-05 | 1.0 | LMNA LMNB2 | Abnormality of facial adipose tissue |
| HP:0003635 | 0.000220402556674 | 1.0 | LMNA LMNB2 | Loss of subcutaneous adipose tissue in limbs |
| HP:0005328 | 0.000260475748797 | 1.0 | LMNA LMNB2 | Progeroid facial appearance |
| WP:WP314 | 0.000320792526609 | 1.0 | LMNA LMNB2 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| HP:0005339 | 0.000701280862145 | 1.0 | LMNA LMNB2 | Abnormality of complement system |
| HP:0008887 | 0.00100182980306 | 1.0 | LMNA LMNB2 | Adipose tissue loss |
| KEGG:04210 | 0.00113070596705 | 1.0 | LMNA LMNB2 | Apoptosis |
| HP:0040063 | 0.0022240621628 | 1.0 | LMNA LMNB2 | Decreased adipose tissue |
| HP:0000147 | 0.00330603835011 | 1.0 | LMNA LMNB2 | Polycystic ovaries |
| HP:0100820 | 0.00345631282057 | 1.0 | LMNA LMNB2 | Glomerulopathy |
| HP:0000138 | 0.00392717282801 | 1.0 | LMNA LMNB2 | Ovarian cyst |
| HP:0000855 | 0.00591079583808 | 1.0 | LMNA LMNB2 | Insulin resistance |
| HP:0003700 | 0.00631486719198 | 1.0 | LMNA LMNB2 | Generalized amyotrophy |
| HP:0100578 | 0.00926692567834 | 1.0 | LMNA LMNB2 | Lipoatrophy |
| HP:0003621 | 0.0113640893994 | 1.0 | LMNA LMNB2 | Juvenile onset |
| HP:0001397 | 0.0158723235132 | 1.0 | LMNA LMNB2 | Hepatic steatosis |
| HP:0002230 | 0.0161995879155 | 1.0 | LMNA LMNB2 | Generalized hirsutism |
| HP:0031065 | 0.0161995879155 | 1.0 | LMNA LMNB2 | Abnormal ovarian morphology |
| HP:0007495 | 0.0165301917506 | 1.0 | LMNA LMNB2 | Prematurely aged appearance |
| WP:WP4299 | 0.0166454435758 | 0.5 | LMNA | Lamin A-processing pathway |
| HP:0009125 | 0.0172014177186 | 1.0 | LMNA LMNB2 | Lipodystrophy |
| HP:0031137 | 0.0189379227106 | 1.0 | LMNA LMNB2 | Storage in hepatocytes |
| HP:0006561 | 0.0189379227106 | 1.0 | LMNA LMNB2 | Lipid accumulation in hepatocytes |
| HP:0002829 | 0.0254665135939 | 1.0 | LMNA LMNB2 | Arthralgia |
| HP:0000095 | 0.0258806032458 | 1.0 | LMNA LMNB2 | Abnormality of renal glomerulus morphology |
| HP:0031263 | 0.0258806032458 | 1.0 | LMNA LMNB2 | Abnormal renal corpuscle morphology |
| HP:0011035 | 0.0358354520556 | 1.0 | LMNA LMNB2 | Abnormal renal cortex morphology |
| HP:0001007 | 0.0414189834913 | 1.0 | LMNA LMNB2 | Hirsutism |
| HP:0012575 | 0.047406586281 | 1.0 | LMNA LMNB2 | Abnormal nephron morphology |
| HP:0009124 | 0.0496840793666 | 1.0 | LMNA LMNB2 | Abnormal adipose tissue morphology |
| HP:0010330 | 0.0497341708567 | 0.5 | LMNA | Abnormality of the phalanges of the 3rd toe |
| HP:0012645 | 0.0497341708567 | 0.5 | LMNA | Enlarged peripheral nerve |
| HP:0012723 | 0.0497341708567 | 0.5 | LMNA | Sinoatrial block |
| HP:0009019 | 0.0497341708567 | 0.5 | LMNB2 | Progressive loss of facial adipose tissue |
| HP:0008985 | 0.0497341708567 | 0.5 | LMNA | Increased intramuscular fat |
| HP:0100362 | 0.0497341708567 | 0.5 | LMNA | Aplasia of the phalanges of the 3rd toe |
| HP:0008739 | 0.0497341708567 | 0.5 | LMNA | Labial pseudohypertrophy |
| HP:0000287 | 0.0497341708567 | 0.5 | LMNA | Increased facial adipose tissue |
| HP:0010359 | 0.0497341708567 | 0.5 | LMNA | Aplasia/Hypoplasia of the phalanges of the 3rd toe |
| HP:0009056 | 0.0497341708567 | 0.5 | LMNB2 | Loss of subcutaneous adipose tissue from upper limbs |
| CORUM:6091 | 0.0499173803268 | 0.5 | LMNA | NF-YA-LaminA complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LMNA | LMNB2 | 0.994 | 0.923 | hein_WMM bioplex (LMNA) bioplex_WMM youn_WMM hein (LMNA) gupta_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_06899 has an average edge precision of 0.923 which is ranked 461 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LMNA | HuMAP2_01147 HuMAP2_01943 HuMAP2_06899 |
| LMNB2 | HuMAP2_01147 HuMAP2_02186 HuMAP2_02630 HuMAP2_04524 HuMAP2_05795 HuMAP2_06899 |