hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06904
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GRK2 | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | UniProt NCBI |
| GRK3 | Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04340 | 0.000138019076752 | 1.0 | GRK3 GRK2 | Hedgehog signaling pathway |
| WP:WP4249 | 0.000261924676198 | 1.0 | GRK3 GRK2 | Hedgehog Signaling Pathway |
| KEGG:05032 | 0.000472708042999 | 1.0 | GRK3 GRK2 | Morphine addiction |
| KEGG:04724 | 0.000722192843471 | 1.0 | GRK3 GRK2 | Glutamatergic synapse |
| KEGG:04740 | 0.00111261467158 | 1.0 | GRK3 GRK2 | Olfactory transduction |
| KEGG:04062 | 0.00122335090758 | 1.0 | GRK3 GRK2 | Chemokine signaling pathway |
| GO:0047696 | 0.00270494046827 | 1.0 | GRK3 GRK2 | beta-adrenergic receptor kinase activity |
| KEGG:04144 | 0.00387576825996 | 1.0 | GRK3 GRK2 | Endocytosis |
| REAC:R-HSA-8856825 | 0.00656291627866 | 1.0 | GRK3 GRK2 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-8856828 | 0.0138364241054 | 1.0 | GRK3 GRK2 | Clathrin-mediated endocytosis |
| REAC:R-HSA-418555 | 0.0258092213206 | 1.0 | GRK3 GRK2 | G alpha (s) signalling events |
| MIRNA:hsa-miR-6794-3p | 0.0260472731237 | 1.0 | GRK3 GRK2 | hsa-miR-6794-3p |
| MIRNA:hsa-miR-4639-3p | 0.0349795514371 | 1.0 | GRK3 GRK2 | hsa-miR-4639-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRK3 | GRK2 | 1.0 | 0.949 | bioplex (GRK2) bioplex_WMM |
Images
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Complex HuMAP2_06904 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GRK2 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |
| GRK3 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |