hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06907
Confidence: High  
ProteinsGenename | Protein Name | Links |
---|---|---|
PRCP | Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP) | UniProt   NCBI |
SHMT2 | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | UniProt   NCBI |
SHMT1 | Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | UniProt   NCBI |
OAT | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form] | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  WP:WP1495 | 5.0398104697e-06 | 0.5 | SHMT1 SHMT2 | Glycine Metabolism |
  KEGG:00670 | 0.000306120927358 | 0.5 | SHMT1 SHMT2 | One carbon pool by folate |
  GO:0030170 | 0.000351729129078 | 0.75 | SHMT1 SHMT2 OAT | pyridoxal phosphate binding |
  GO:0070279 | 0.000351729129078 | 0.75 | SHMT1 SHMT2 OAT | vitamin B6 binding |
  WP:WP241 | 0.000633595541779 | 0.5 | SHMT1 SHMT2 | One Carbon Metabolism |
  KEGG:01523 | 0.000649790903665 | 0.5 | SHMT1 SHMT2 | Antifolate resistance |
  WP:WP2525 | 0.000729007032317 | 0.5 | SHMT1 SHMT2 | Trans-sulfuration and one carbon metabolism |
  KEGG:00630 | 0.000869408386689 | 0.5 | SHMT1 SHMT2 | Glyoxylate and dicarboxylate metabolism |
  REAC:R-HSA-196757 | 0.00105460323216 | 0.5 | SHMT1 SHMT2 | Metabolism of folate and pterines |
  KEGG:00260 | 0.00147979776218 | 0.5 | SHMT1 SHMT2 | Glycine, serine and threonine metabolism |
  WP:WP3940 | 0.00188734205227 | 0.5 | SHMT1 SHMT2 | One carbon metabolism and related pathways |
  WP:WP176 | 0.00230460203011 | 0.5 | SHMT1 SHMT2 | Folate Metabolism |
  GO:0004372 | 0.00270494046827 | 0.5 | SHMT1 SHMT2 | glycine hydroxymethyltransferase activity |
  GO:1904481 | 0.00270494046827 | 0.5 | SHMT1 SHMT2 | response to tetrahydrofolate |
  GO:1904482 | 0.00270494046827 | 0.5 | SHMT1 SHMT2 | cellular response to tetrahydrofolate |
  GO:0019264 | 0.00270494046827 | 0.5 | SHMT1 SHMT2 | glycine biosynthetic process from serine |
  KEGG:01230 | 0.00494838688052 | 0.5 | SHMT1 SHMT2 | Biosynthesis of amino acids |
  WP:WP4018 | 0.00527207105384 | 0.5 | SHMT1 SHMT2 | Pathways in clear cell renal cell carcinoma |
  GO:0019842 | 0.00587743889796 | 0.75 | SHMT1 SHMT2 OAT | vitamin binding |
  GO:0070905 | 0.00811409485621 | 0.5 | SHMT1 SHMT2 | serine binding |
  GO:0050897 | 0.00811409485621 | 0.5 | SHMT1 SHMT2 | cobalt ion binding |
  KEGG:01200 | 0.012776519361 | 0.5 | SHMT1 SHMT2 | Carbon metabolism |
  GO:0006545 | 0.0162267366884 | 0.5 | SHMT1 SHMT2 | glycine biosynthetic process |
  GO:0006565 | 0.0162267366884 | 0.5 | SHMT1 SHMT2 | L-serine catabolic process |
  GO:0008652 | 0.0198185309013 | 0.75 | SHMT1 SHMT2 OAT | cellular amino acid biosynthetic process |
  GO:0043648 | 0.023464682987 | 0.75 | SHMT1 SHMT2 OAT | dicarboxylic acid metabolic process |
  GO:0016742 | 0.0270421395626 | 0.5 | SHMT1 SHMT2 | hydroxymethyl-, formyl- and related transferase activity |
  MIRNA:hsa-miR-134-3p | 0.0291936286934 | 0.5 | SHMT1 SHMT2 | hsa-miR-134-3p |
  MIRNA:hsa-miR-7114-5p | 0.0381896870696 | 0.5 | SHMT1 SHMT2 | hsa-miR-7114-5p |
  GO:1901606 | 0.0396936057372 | 0.75 | SHMT1 SHMT2 OAT | alpha-amino acid catabolic process |
  CORUM:7113 | 0.0499140284799 | 0.25 | SHMT1 | ABRAXAS2-SHMT1 complex |
  CORUM:7114 | 0.0499140284799 | 0.25 | SHMT2 | ABRAXAS2-SHMT2 complex |
Edges
Protein 1 | Protein 2 | Score | Precision | Evidence |
---|---|---|---|---|
 OAT |  SHMT2 | 0.696 | 0.718           | bioplex_WMM     Guru     youn_WMM     gupta_WMM     fraction     treiber_WMM     |
 SHMT1 |  OAT | 0.581 | 0.663           | Guru     fraction     |
 PRCP |  OAT | 0.558 | 0.649           | bioplex_WMM     fraction     |
 PRCP |  SHMT2 | 0.004 | 0.013           | bioplex_WMM     fraction     |
 SHMT1 |  PRCP | 0.0 | 0.011           | fraction     |
 SHMT1 |  SHMT2 | 0.0 | 0.009           | bioplex (SHMT1,SHMT2)     bioplex_WMM     youn_WMM     fraction     |
Images
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Complex HuMAP2_06907 has an average edge precision of 0.344 which is ranked 4069 out of all 6965 complexes.
Related Complexes