hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06910
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HADH | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase) | UniProt NCBI |
| AKR1C1 | Aldo-keto reductase family 1 member C1 (EC 1.1.1.-) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid-binding protein) (HBAB) (Indanol dehydrogenase) (EC 1.1.1.112) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) | UniProt NCBI |
| UPP1 | Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3) | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | UniProt NCBI |
| AKR1B10 | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | UniProt NCBI |
| PGM2L1 | Glucose 1,6-bisphosphate synthase (EC 2.7.1.106) (PMMLP) (Phosphoglucomutase-2-like 1) | UniProt NCBI |
| AKR1D1 | Aldo-keto reductase family 1 member D1 (EC 1.3.1.3) (3-oxo-5-beta-steroid 4-dehydrogenase) (Delta(4)-3-ketosteroid 5-beta-reductase) (Delta(4)-3-oxosteroid 5-beta-reductase) | UniProt NCBI |
| ATOX1 | Copper transport protein ATOX1 (Metal transport protein ATX1) | UniProt NCBI |
| PPIAL4D | Peptidyl-prolyl cis-trans isomerase A-like 4D (PPIase A-like 4D) (EC 5.2.1.8) | UniProt NCBI |
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | UniProt NCBI |
| AKR1B15 | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016616 | 8.61672267565e-09 | 0.636363636364 | HADH AKR1C1 AKR1B15 LDHA AKR1D1 LDHB AKR1B10 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016614 | 1.39459342968e-08 | 0.636363636364 | HADH AKR1C1 AKR1B15 LDHA AKR1D1 LDHB AKR1B10 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0004032 | 2.64968960261e-06 | 0.363636363636 | AKR1D1 AKR1B15 AKR1C1 AKR1B10 | alditol:NADP+ 1-oxidoreductase activity |
| GO:0008106 | 1.90667842707e-05 | 0.363636363636 | AKR1D1 AKR1B15 AKR1C1 AKR1B10 | alcohol dehydrogenase (NADP+) activity |
| GO:0004033 | 5.84921394707e-05 | 0.363636363636 | AKR1D1 AKR1B15 AKR1C1 AKR1B10 | aldo-keto reductase (NADP) activity |
| REAC:R-HSA-1430728 | 7.48427763869e-05 | 0.818181818182 | HADH UPP1 LDHB AKR1B15 AKR1D1 LDHA AKR1C1 PGM2L1 AKR1B10 | Metabolism |
| KEGG:01100 | 0.000379538868165 | 0.636363636364 | HADH UPP1 LDHB AKR1D1 LDHA PGM2L1 AKR1B10 | Metabolic pathways |
| GO:0016491 | 0.00155580779931 | 0.636363636364 | HADH AKR1C1 AKR1B15 LDHA AKR1D1 LDHB AKR1B10 | oxidoreductase activity |
| REAC:R-HSA-193807 | 0.00844507994095 | 0.181818181818 | AKR1D1 AKR1C1 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| REAC:R-HSA-193775 | 0.00844507994095 | 0.181818181818 | AKR1D1 AKR1C1 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| KEGG:00640 | 0.0123711089661 | 0.181818181818 | LDHA LDHB | Propanoate metabolism |
| WP:WP702 | 0.0125157402692 | 0.272727272727 | AKR1D1 AKR1C1 AKR1B10 | Metapathway biotransformation Phase I and II |
| KEGG:00620 | 0.0163075575804 | 0.181818181818 | LDHA LDHB | Pyruvate metabolism |
| REAC:R-HSA-8957322 | 0.0203569016388 | 0.272727272727 | AKR1D1 AKR1C1 AKR1B15 | Metabolism of steroids |
| KEGG:00140 | 0.020777189107 | 0.181818181818 | AKR1D1 AKR1C1 | Steroid hormone biosynthesis |
| GO:0032787 | 0.0213356872108 | 0.545454545455 | HADH AKR1C1 AKR1D1 LDHA PGM2L1 LDHB | monocarboxylic acid metabolic process |
| REAC:R-HSA-193368 | 0.02266357179 | 0.181818181818 | AKR1D1 AKR1C1 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| KEGG:00270 | 0.0227136005564 | 0.181818181818 | LDHA LDHB | Cysteine and methionine metabolism |
| GO:0016229 | 0.0300740998178 | 0.272727272727 | AKR1D1 AKR1C1 AKR1B15 | steroid dehydrogenase activity |
| WP:WP534 | 0.0312079565748 | 0.181818181818 | LDHA LDHB | Glycolysis and Gluconeogenesis |
| KEGG:00010 | 0.0425669669122 | 0.181818181818 | LDHA LDHB | Glycolysis / Gluconeogenesis |
| REAC:R-HSA-70268 | 0.0436752094358 | 0.181818181818 | LDHA LDHB | Pyruvate metabolism |
| REAC:R-HSA-192105 | 0.0467760136448 | 0.181818181818 | AKR1D1 AKR1C1 | Synthesis of bile acids and bile salts |
| KEGG:05230 | 0.0481126379603 | 0.181818181818 | LDHA LDHB | Central carbon metabolism in cancer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1B10 | AKR1B15 | 0.998 | 0.939 | bioplex (AKR1B10) bioplex_WMM |
| LDHB | AKR1B15 | 0.709 | 0.728 | fraction |
| LDHA | AKR1B15 | 0.709 | 0.729 | fraction treiber_WMM |
| AKR1B15 | PPIAL4D | 0.69 | 0.715 | fraction |
| AKR1C1 | PPIAL4D | 0.262 | 0.482 | fraction |
| LDHA | AKR1B10 | 0.246 | 0.469 | bioplex (AKR1B10) fraction treiber_WMM |
| AKR1B10 | LDHB | 0.241 | 0.468 | bioplex (AKR1B10) fraction treiber_WMM |
| LDHA | LDHB | 0.203 | 0.455 | hein_WMM bioplex (LDHA,LDHB) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| UPP1 | AKR1C1 | 0.158 | 0.415 | fraction |
| UPP1 | LDHB | 0.112 | 0.38 | fraction treiber_WMM |
| UPP1 | PGM2L1 | 0.09 | 0.355 | fraction |
| AKR1B15 | HADH | 0.089 | 0.356 | fraction |
| UPP1 | HADH | 0.081 | 0.35 | fraction treiber_WMM |
| UPP1 | LDHA | 0.067 | 0.351 | fraction treiber_WMM |
| PGM2L1 | ATOX1 | 0.062 | 0.341 | fraction |
| AKR1C1 | ATOX1 | 0.062 | 0.34 | fraction |
| LDHA | AKR1C1 | 0.061 | 0.335 | bioplex (AKR1C1) fraction treiber_WMM |
| AKR1D1 | ATOX1 | 0.057 | 0.316 | fraction |
| LDHB | AKR1D1 | 0.053 | 0.301 | bioplex (AKR1D1) fraction |
| AKR1B15 | ATOX1 | 0.052 | 0.304 | fraction |
| LDHB | PGM2L1 | 0.051 | 0.296 | bioplex (PGM2L1) fraction |
| UPP1 | PPIAL4D | 0.049 | 0.294 | fraction |
| AKR1C1 | AKR1D1 | 0.029 | 0.231 | bioplex (AKR1C1) bioplex_WMM |
| PPIAL4D | ATOX1 | 0.022 | 0.204 | fraction |
| AKR1B10 | ATOX1 | 0.014 | 0.143 | fraction |
| LDHA | AKR1D1 | 0.007 | 0.01 | bioplex (AKR1D1) |
| LDHA | PGM2L1 | 0.007 | 0.004 | bioplex (PGM2L1) fraction |
| LDHB | AKR1C1 | 0.007 | 0.006 | bioplex (AKR1C1) |
| AKR1B10 | AKR1D1 | 0.003 | 0.014 | bioplex (AKR1D1) bioplex_WMM |
| HADH | ATOX1 | 0.0 | 0.011 | bioplex_WMM fraction |
| LDHB | ATOX1 | 0.0 | 0.013 | youn_WMM fraction |
| LDHA | ATOX1 | 0.0 | 0.006 | bioplex_WMM fraction |
| UPP1 | ATOX1 | 0.0 | 0.001 | fraction |
| LDHB | HADH | 0.0 | 0.003 | bioplex_WMM youn_WMM fraction treiber_WMM |
| LDHA | HADH | 0.0 | 0.002 | bioplex_WMM youn_WMM fraction treiber_WMM |
Images
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Complex HuMAP2_06910 has an average edge precision of 0.296 which is ranked 4651 out of all 6965 complexes.
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