hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06911
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ACOX1 | Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain] | UniProt NCBI |
| RAB1A | Ras-related protein Rab-1A (YPT1-related protein) | UniProt NCBI |
| RAB1B | Ras-related protein Rab-1B | UniProt NCBI |
| RAB33B | Ras-related protein Rab-33B | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8873719 | 5.0922703922e-05 | 0.75 | RAB1A RAB1B RAB33B | RAB geranylgeranylation |
| REAC:R-HSA-9007101 | 0.000340340039133 | 0.75 | RAB1A RAB1B RAB33B | Rab regulation of trafficking |
| REAC:R-HSA-162658 | 0.000783559910601 | 0.5 | RAB1B RAB1A | Golgi Cisternae Pericentriolar Stack Reorganization |
| REAC:R-HSA-6811442 | 0.00167812264469 | 0.75 | RAB1A RAB1B RAB33B | Intra-Golgi and retrograde Golgi-to-ER traffic |
| KEGG:05134 | 0.00206562690353 | 0.5 | RAB1B RAB1A | Legionellosis |
| KEGG:04140 | 0.0173825101547 | 0.5 | RAB33B RAB1A | Autophagy - animal |
| REAC:R-HSA-204005 | 0.0183045753359 | 0.5 | RAB1B RAB1A | COPII-mediated vesicle transport |
| GO:0032482 | 0.0206918321066 | 0.75 | RAB1A RAB1B RAB33B | Rab protein signal transduction |
| WP:WP1941 | 0.0333519728792 | 0.25 | ACOX1 | Peroxisomal beta-oxidation of tetracosanoyl-CoA |
| REAC:R-HSA-8876198 | 0.0356320611636 | 0.5 | RAB1B RAB1A | RAB GEFs exchange GTP for GDP on RABs |
| GO:0006890 | 0.0357324157151 | 0.75 | RAB1A RAB1B RAB33B | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| REAC:R-HSA-199991 | 0.0426366599823 | 0.75 | RAB1A RAB1B RAB33B | Membrane Trafficking |
| REAC:R-HSA-6811434 | 0.0454682616856 | 0.5 | RAB1B RAB1A | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 0.0464213162589 | 0.5 | RAB1B RAB1A | COPI-mediated anterograde transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB1B | RAB1A | 1.0 | 0.949 | bioplex (RAB1A,RAB1B) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RAB33B | RAB1B | 0.123 | 0.395 | bioplex (RAB1B) bioplex_WMM |
| ACOX1 | RAB1B | 0.055 | 0.304 | bioplex_WMM fraction |
| ACOX1 | RAB1A | 0.048 | 0.295 | bioplex_WMM fraction |
| RAB33B | RAB1A | 0.021 | 0.191 | bioplex (RAB1A) bioplex_WMM treiber_WMM |
| RAB33B | ACOX1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06911 has an average edge precision of 0.356 which is ranked 3832 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ACOX1 | HuMAP2_00843 HuMAP2_05984 HuMAP2_06911 |
| RAB1A | HuMAP2_04939 HuMAP2_06911 |
| RAB1B | HuMAP2_02053 HuMAP2_04939 HuMAP2_06911 |
| RAB33B | HuMAP2_00453 HuMAP2_01308 HuMAP2_01394 HuMAP2_01766 HuMAP2_02053 HuMAP2_06911 |