hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06916
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CLTC | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) | UniProt NCBI |
| CLTA | Clathrin light chain A (Lca) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168275 | 1.67592346237e-06 | 1.0 | CLTA CLTC | Entry of Influenza Virion into Host Cell via Endocytosis |
| REAC:R-HSA-196025 | 9.21757904306e-05 | 1.0 | CLTA CLTC | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.000110610948517 | 1.0 | CLTA CLTC | Gap junction degradation |
| REAC:R-HSA-8866427 | 0.000110610948517 | 1.0 | CLTA CLTC | VLDLR internalisation and degradation |
| REAC:R-HSA-177504 | 0.000130722030065 | 1.0 | CLTA CLTC | Retrograde neurotrophin signalling |
| REAC:R-HSA-5140745 | 0.000130722030065 | 1.0 | CLTA CLTC | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| REAC:R-HSA-5099900 | 0.000152509035076 | 1.0 | CLTA CLTC | WNT5A-dependent internalization of FZD4 |
| KEGG:04961 | 0.000178724491566 | 1.0 | CLTA CLTC | Endocrine and other factor-regulated calcium reabsorption |
| REAC:R-HSA-8964038 | 0.000286582912066 | 1.0 | CLTA CLTC | LDL clearance |
| KEGG:04721 | 0.000322579470084 | 1.0 | CLTA CLTC | Synaptic vesicle cycle |
| KEGG:05100 | 0.000383418745988 | 1.0 | CLTA CLTC | Bacterial invasion of epithelial cells |
| WP:WP2267 | 0.000385621678328 | 1.0 | CLTA CLTC | Synaptic Vesicle Pathway |
| REAC:R-HSA-8964043 | 0.000680424925724 | 1.0 | CLTA CLTC | Plasma lipoprotein clearance |
| REAC:R-HSA-190828 | 0.000940193062392 | 1.0 | CLTA CLTC | Gap junction trafficking |
| REAC:R-HSA-432720 | 0.000997174460113 | 1.0 | CLTA CLTC | Lysosome Vesicle Biogenesis |
| REAC:R-HSA-157858 | 0.000997174460113 | 1.0 | CLTA CLTC | Gap junction trafficking and regulation |
| KEGG:04142 | 0.00100713074717 | 1.0 | CLTA CLTC | Lysosome |
| REAC:R-HSA-437239 | 0.00165916422775 | 1.0 | CLTA CLTC | Recycling pathway of L1 |
| REAC:R-HSA-3928665 | 0.00173458078356 | 1.0 | CLTA CLTC | EPH-ephrin mediated repulsion of cells |
| KEGG:05016 | 0.00224682217969 | 1.0 | CLTA CLTC | Huntington disease |
| WP:WP4549 | 0.00244227062941 | 1.0 | CLTA CLTC | Fragile X Syndrome |
| WP:WP4217 | 0.00257192893285 | 1.0 | CLTA CLTC | Ebola Virus Pathway on Host |
| REAC:R-HSA-174824 | 0.00258092213206 | 1.0 | CLTA CLTC | Plasma lipoprotein assembly, remodeling, and clearance |
| KEGG:04144 | 0.00387576825996 | 1.0 | CLTA CLTC | Endocytosis |
| REAC:R-HSA-199992 | 0.00428366036983 | 1.0 | CLTA CLTC | trans-Golgi Network Vesicle Budding |
| REAC:R-HSA-187037 | 0.00440432685912 | 1.0 | CLTA CLTC | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-2682334 | 0.00612550025498 | 1.0 | CLTA CLTC | EPH-Ephrin signaling |
| REAC:R-HSA-8856825 | 0.00656291627866 | 1.0 | CLTA CLTC | Cargo recognition for clathrin-mediated endocytosis |
| GO:0071439 | 0.00676235117068 | 1.0 | CLTA CLTC | clathrin complex |
| REAC:R-HSA-4086400 | 0.00686290657842 | 1.0 | CLTA CLTC | PCP/CE pathway |
| REAC:R-HSA-166520 | 0.00686290657842 | 1.0 | CLTA CLTC | Signaling by NTRKs |
| REAC:R-HSA-373760 | 0.0102315127378 | 1.0 | CLTA CLTC | L1CAM interactions |
| REAC:R-HSA-2132295 | 0.011178409494 | 1.0 | CLTA CLTC | MHC class II antigen presentation |
| REAC:R-HSA-8856828 | 0.0138364241054 | 1.0 | CLTA CLTC | Clathrin-mediated endocytosis |
| REAC:R-HSA-3858494 | 0.0156129029755 | 1.0 | CLTA CLTC | Beta-catenin independent WNT signaling |
| REAC:R-HSA-168255 | 0.0158425044898 | 1.0 | CLTA CLTC | Influenza Life Cycle |
| REAC:R-HSA-168254 | 0.0182306954237 | 1.0 | CLTA CLTC | Influenza Infection |
| GO:0036020 | 0.0247952876258 | 1.0 | CLTA CLTC | endolysosome membrane |
| GO:0048268 | 0.029754345151 | 1.0 | CLTA CLTC | clathrin coat assembly |
| GO:0032802 | 0.0473364581948 | 1.0 | CLTA CLTC | low-density lipoprotein particle receptor catabolic process |
| CORUM:6691 | 0.0499173803268 | 0.5 | CLTC | CLTC-PI4K2A complex |
| CORUM:7269 | 0.0499173803268 | 0.5 | CLTC | p532-Clathrin-HSP70 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CLTC | CLTA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (CLTC) Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_06916 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CLTC | HuMAP2_01298 HuMAP2_01713 HuMAP2_02813 HuMAP2_03895 HuMAP2_06916 |
| CLTA | HuMAP2_02813 HuMAP2_03895 HuMAP2_06916 |