hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06950
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TINAGL1 | Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) | UniProt NCBI |
| WDR77 | Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50) | UniProt NCBI |
| PRMT5 | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | UniProt NCBI |
| COPRS | Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1) | UniProt NCBI |
| CLNS1A | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | UniProt NCBI |
| RIOK1 | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2838 | 2.25356268047e-09 | 0.5 | WDR77 CLNS1A PRMT5 | MEP50-PRMT5-ICLN complex |
| CORUM:837 | 2.25356268047e-09 | 0.5 | WDR77 CLNS1A PRMT5 | MEP50-PRMT5-ICLN complex |
| CORUM:6853 | 8.39001385941e-06 | 0.333333333333 | COPRS PRMT5 | COPRS-PRMT5 complex |
| CORUM:836 | 8.39001385941e-06 | 0.333333333333 | CLNS1A PRMT5 | 20S methyltransferase core complex |
| CORUM:825 | 2.51655344529e-05 | 0.333333333333 | CLNS1A PRMT5 | JBP1-pICln complex |
| CORUM:819 | 5.0322056017e-05 | 0.333333333333 | CLNS1A PRMT5 | 20S methylosome-SmD complex |
| CORUM:6852 | 5.0322056017e-05 | 0.333333333333 | COPRS PRMT5 | COPRS-PRMT5-RUNX1-CBFB complex |
| CORUM:6858 | 8.38550741504e-05 | 0.333333333333 | WDR77 PRMT5 | CHTOP-methylosome complex |
| REAC:R-HSA-194441 | 0.000115897320389 | 0.5 | WDR77 CLNS1A PRMT5 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.000115897320389 | 0.5 | WDR77 CLNS1A PRMT5 | snRNP Assembly |
| CORUM:832 | 0.000125760085813 | 0.333333333333 | CLNS1A PRMT5 | Anti-Sm protein complex |
| CORUM:834 | 0.000125760085813 | 0.333333333333 | CLNS1A PRMT5 | 20S methylosome and RG-containing Sm protein complex |
| CORUM:810 | 0.000176032589326 | 0.333333333333 | WDR77 PRMT5 | FCP1-associated protein complex |
| CORUM:811 | 0.000176032589326 | 0.333333333333 | WDR77 PRMT5 | FCP1-associated protein complex |
| GO:0034709 | 0.00039905855691 | 0.5 | WDR77 CLNS1A PRMT5 | methylosome |
| REAC:R-HSA-3214858 | 0.000447942844044 | 0.5 | COPRS PRMT5 WDR77 | RMTs methylate histone arginines |
| GO:0034708 | 0.00186759839818 | 0.666666666667 | WDR77 CLNS1A RIOK1 PRMT5 | methyltransferase complex |
| REAC:R-HSA-8953854 | 0.00833913786065 | 0.666666666667 | WDR77 CLNS1A RIOK1 PRMT5 | Metabolism of RNA |
| GO:0000387 | 0.0152420239566 | 0.5 | WDR77 CLNS1A PRMT5 | spliceosomal snRNP assembly |
| REAC:R-HSA-4839726 | 0.0183482160149 | 0.5 | COPRS PRMT5 WDR77 | Chromatin organization |
| REAC:R-HSA-3247509 | 0.0183482160149 | 0.5 | COPRS PRMT5 WDR77 | Chromatin modifying enzymes |
| GO:0043985 | 0.020283420769 | 0.333333333333 | COPRS PRMT5 | histone H4-R3 methylation |
| CORUM:1748 | 0.0249904952816 | 0.166666666667 | PRMT5 | PRMT5 complex |
| CORUM:2764 | 0.0249904952816 | 0.166666666667 | PRMT5 | PRMT5 complex |
| CORUM:7410 | 0.0499726005494 | 0.166666666667 | PRMT5 | CAPG-PRMT5 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR77 | PRMT5 | 1.0 | 0.949 | hein_WMM bioplex (WDR77) bioplex_WMM boldt youn_WMM hein (PRMT5) Malo gupta_WMM fraction boldt_WMM |
| CLNS1A | PRMT5 | 0.865 | 0.801 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| PRMT5 | COPRS | 0.492 | 0.62 | hein_WMM bioplex_WMM youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| PRMT5 | RIOK1 | 0.362 | 0.543 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRMT5) gupta_WMM boldt_WMM |
| TINAGL1 | RIOK1 | 0.09 | 0.355 | bioplex (TINAGL1) bioplex_WMM |
| TINAGL1 | PRMT5 | 0.072 | 0.356 | bioplex (TINAGL1) bioplex_WMM |
| WDR77 | RIOK1 | 0.049 | 0.293 | hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM |
| WDR77 | COPRS | 0.033 | 0.253 | hein_WMM bioplex_WMM youn_WMM WMM_only boldt_WMM |
| COPRS | RIOK1 | 0.028 | 0.231 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| CLNS1A | WDR77 | 0.027 | 0.223 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CLNS1A | COPRS | 0.025 | 0.211 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| CLNS1A | RIOK1 | 0.023 | 0.207 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| TINAGL1 | WDR77 | 0.007 | 0.005 | bioplex (TINAGL1) bioplex_WMM |
| CLNS1A | TINAGL1 | 0.003 | 0.011 | bioplex (TINAGL1) |
Images
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Complex HuMAP2_06950 has an average edge precision of 0.361 which is ranked 3740 out of all 6965 complexes.
Related Complexes