hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06953
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CXXC1 | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | UniProt NCBI |
| SETD1A | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.43) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | UniProt NCBI |
| BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1 | UniProt NCBI |
| SETD1B | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.43) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | UniProt NCBI |
| MDK | Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein) | UniProt NCBI |
| ASH2L | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | UniProt NCBI |
| RBBP5 | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | UniProt NCBI |
| HCFC2 | Host cell factor 2 (HCF-2) (C2 factor) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6470 | 7.90274535478e-17 | 0.75 | ASH2L HCFC2 SETD1B BOD1L1 CXXC1 RBBP5 | Set1B complex |
| CORUM:6469 | 1.06951346208e-13 | 0.625 | HCFC2 ASH2L CXXC1 RBBP5 SETD1A | Set1A complex |
| CORUM:2731 | 2.37077133267e-11 | 0.5 | ASH2L CXXC1 RBBP5 SETD1A | Set1A complex |
| CORUM:2730 | 2.37077133267e-11 | 0.5 | ASH2L CXXC1 RBBP5 SETD1B | Set1B complex |
| GO:0048188 | 2.11728099041e-10 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | Set1C/COMPASS complex |
| GO:0042800 | 1.37530818231e-09 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | histone methyltransferase activity (H3-K4 specific) |
| GO:0018024 | 2.62622334356e-07 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | histone-lysine N-methyltransferase activity |
| CORUM:6460 | 5.64097851901e-07 | 0.375 | ASH2L HCFC2 RBBP5 | MLL2 complex |
| GO:0042054 | 7.79858175868e-07 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | histone methyltransferase activity |
| GO:0016279 | 1.18288344743e-06 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | protein-lysine N-methyltransferase activity |
| GO:0016278 | 1.30588062175e-06 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | lysine N-methyltransferase activity |
| REAC:R-HSA-3214841 | 5.79961458636e-06 | 0.5 | ASH2L SETD1A RBBP5 SETD1B | PKMTs methylate histone lysines |
| GO:0008276 | 8.3746631934e-06 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | protein methyltransferase activity |
| GO:0035097 | 1.08900176497e-05 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | histone methyltransferase complex |
| GO:0008170 | 1.39754540659e-05 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | N-methyltransferase activity |
| REAC:R-HSA-8936459 | 1.66027159348e-05 | 0.5 | ASH2L SETD1A RBBP5 SETD1B | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| CORUM:6850 | 3.50546248845e-05 | 0.25 | ASH2L RBBP5 | WRA complex (WDR5, RBBP5, ASH2L) |
| GO:0034708 | 4.79384344037e-05 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | methyltransferase complex |
| CORUM:6845 | 7.00904180673e-05 | 0.25 | ASH2L RBBP5 | NIF1-ASH2L-RBBP5-WDR5 complex |
| CORUM:7367 | 7.00904180673e-05 | 0.25 | ASH2L RBBP5 | ASH2L-KDM6B-KDM6B-WDR5 complex |
| CORUM:6457 | 7.00904180673e-05 | 0.25 | ASH2L RBBP5 | MLL1 core complex |
| CORUM:1399 | 7.00904180673e-05 | 0.25 | ASH2L RBBP5 | WDR5-ASH2L-RBBP5-MLL2 complex |
| CORUM:6849 | 7.00904180673e-05 | 0.25 | ASH2L RBBP5 | WRAD complex (WDR5, RBBP5, ASH2L, DPY30) |
| CORUM:6340 | 0.00011678598518 | 0.25 | ASH2L RBBP5 | PITX2-MLL4-ASH2L-RBBP5-PTIP complex |
| CORUM:6851 | 0.00011678598518 | 0.25 | ASH2L RBBP5 | MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30) |
| GO:0051568 | 0.000125134574466 | 0.5 | ASH2L CXXC1 RBBP5 SETD1B | histone H3-K4 methylation |
| GO:0008757 | 0.000186979517477 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | S-adenosylmethionine-dependent methyltransferase activity |
| CORUM:1254 | 0.000245118829946 | 0.25 | ASH2L RBBP5 | Menin-associated histone methyltransferase complex |
| CORUM:1256 | 0.000245118829946 | 0.25 | ASH2L RBBP5 | MLL-HCF complex |
| CORUM:1400 | 0.000245118829946 | 0.25 | ASH2L RBBP5 | ASCOM complex |
| CORUM:6462 | 0.000326737313819 | 0.25 | ASH2L RBBP5 | MLL1 complex |
| GO:0008168 | 0.000378328505435 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | methyltransferase activity |
| CORUM:6461 | 0.000419977984057 | 0.25 | ASH2L RBBP5 | MLL3 complex |
| CORUM:6467 | 0.000419977984057 | 0.25 | ASH2L RBBP5 | MLL4 complex |
| GO:0016741 | 0.000482931414846 | 0.625 | ASH2L RBBP5 CXXC1 SETD1B SETD1A | transferase activity, transferring one-carbon groups |
| CORUM:1401 | 0.000524831455609 | 0.25 | SETD1A RBBP5 | MOF complex |
| CORUM:5195 | 0.000524831455609 | 0.25 | ASH2L RBBP5 | PTIP-HMT complex |
| REAC:R-HSA-8878171 | 0.00053900421153 | 0.5 | ASH2L SETD1A RBBP5 SETD1B | Transcriptional regulation by RUNX1 |
| CORUM:3075 | 0.000769339286093 | 0.25 | ASH2L RBBP5 | UTX-MLL2/3 complex |
| REAC:R-HSA-4839726 | 0.00121993817485 | 0.5 | ASH2L SETD1A RBBP5 SETD1B | Chromatin organization |
| REAC:R-HSA-3247509 | 0.00121993817485 | 0.5 | ASH2L SETD1A RBBP5 SETD1B | Chromatin modifying enzymes |
| GO:0034968 | 0.00137168928737 | 0.5 | ASH2L CXXC1 RBBP5 SETD1B | histone lysine methylation |
| CORUM:2721 | 0.00178059542956 | 0.25 | ASH2L SETD1A | HCF-1 complex |
| GO:0018022 | 0.00279443468871 | 0.5 | ASH2L CXXC1 RBBP5 SETD1B | peptidyl-lysine methylation |
| GO:0016571 | 0.0033979161892 | 0.5 | ASH2L CXXC1 RBBP5 SETD1B | histone methylation |
| CORUM:5386 | 0.00407502785497 | 0.25 | ASH2L RBBP5 | MLL1-WDR5 complex |
| CORUM:0000000 | 0.00993810898821 | 0.875 | ASH2L HCFC2 SETD1B SETD1A BOD1L1 CXXC1 RBBP5 | CORUM root |
| GO:0008213 | 0.0115267991945 | 0.5 | ASH2L CXXC1 RBBP5 SETD1B | protein alkylation |
| GO:0006479 | 0.0115267991945 | 0.5 | ASH2L CXXC1 RBBP5 SETD1B | protein methylation |
| KEGG:00310 | 0.0218622840624 | 0.25 | SETD1B SETD1A | Lysine degradation |
| WP:WP2369 | 0.0269379290762 | 0.25 | SETD1B SETD1A | Histone Modifications |
| REAC:R-HSA-3769402 | 0.0328409413955 | 0.25 | ASH2L RBBP5 | Deactivation of the beta-catenin transactivating complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CXXC1 | SETD1B | 0.997 | 0.931 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1,SETD1B) |
| CXXC1 | SETD1A | 0.994 | 0.919 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| CXXC1 | BOD1L1 | 0.98 | 0.896 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (BOD1L1,CXXC1) |
| CXXC1 | ASH2L | 0.677 | 0.706 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) fraction |
| CXXC1 | RBBP5 | 0.617 | 0.675 | hein_WMM bioplex (CXXC1) bioplex_WMM youn_WMM hein (CXXC1) |
| SETD1A | BOD1L1 | 0.157 | 0.416 | hein_WMM bioplex_WMM youn_WMM hein (BOD1L1) |
| ASH2L | HCFC2 | 0.078 | 0.353 | hein_WMM bioplex (HCFC2) bioplex_WMM |
| HCFC2 | SETD1A | 0.06 | 0.336 | bioplex (HCFC2) bioplex_WMM youn_WMM |
| RBBP5 | SETD1B | 0.043 | 0.269 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
| RBBP5 | HCFC2 | 0.037 | 0.265 | bioplex (HCFC2) bioplex_WMM |
| RBBP5 | ASH2L | 0.034 | 0.26 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CXXC1 | HCFC2 | 0.026 | 0.219 | bioplex (CXXC1,HCFC2) bioplex_WMM |
| SETD1A | MDK | 0.022 | 0.199 | bioplex (MDK) bioplex_WMM |
| ASH2L | SETD1B | 0.016 | 0.155 | hein_WMM bioplex_WMM youn_WMM hein (SETD1B) |
| CXXC1 | MDK | 0.013 | 0.141 | bioplex (MDK) bioplex_WMM |
| HCFC2 | BOD1L1 | 0.013 | 0.147 | bioplex (HCFC2) bioplex_WMM youn_WMM |
| ASH2L | BOD1L1 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RBBP5 | SETD1A | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SETD1B | SETD1A | 0.01 | 0.129 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SETD1B | BOD1L1 | 0.01 | 0.105 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SETD1B | HCFC2 | 0.008 | 0.059 | bioplex_WMM WMM_only |
| ASH2L | MDK | 0.008 | 0.031 | bioplex (MDK) bioplex_WMM |
| RBBP5 | MDK | 0.007 | 0.009 | bioplex (MDK) bioplex_WMM |
| BOD1L1 | MDK | 0.007 | 0.003 | bioplex (MDK) bioplex_WMM |
| RBBP5 | BOD1L1 | 0.005 | 0.007 | hein_WMM bioplex_WMM youn_WMM hein (BOD1L1) |
| ASH2L | SETD1A | 0.0 | 0.014 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_06953 has an average edge precision of 0.29 which is ranked 4753 out of all 6965 complexes.
Related Complexes