hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06955
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RNF213 | E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) (RING-type E3 ubiquitin transferase RNF213) | UniProt NCBI |
| RRP1 | Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein) | UniProt NCBI |
| GSDME | Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)] | UniProt NCBI |
| SCN2B | Sodium channel subunit beta-2 | UniProt NCBI |
| PTPRF | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | UniProt NCBI |
| PTPRD | Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-388844 | 0.00206071490935 | 0.4 | PTPRD PTPRF | Receptor-type tyrosine-protein phosphatases |
| REAC:R-HSA-8849932 | 0.00255837003151 | 0.4 | PTPRD PTPRF | Synaptic adhesion-like molecules |
| REAC:R-HSA-6794362 | 0.0432704002666 | 0.4 | PTPRD PTPRF | Protein-protein interactions at synapses |
| GO:0007185 | 0.0450641792523 | 0.4 | PTPRD PTPRF | transmembrane receptor protein tyrosine phosphatase signaling pathway |
| CORUM:6333 | 0.0499494897235 | 0.2 | SCN2B | Nav1.2-beta2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SCN2B | RNF213 | 0.992 | 0.912 | bioplex (SCN2B) bioplex_WMM |
| RRP1 | SCN2B | 0.353 | 0.539 | bioplex (SCN2B) bioplex_WMM |
| SCN2B | PTPRF | 0.352 | 0.538 | bioplex (SCN2B) bioplex_WMM |
| SCN2B | GSDME | 0.024 | 0.21 | bioplex (SCN2B) bioplex_WMM |
| SCN2B | PTPRD | 0.023 | 0.209 | bioplex (SCN2B) bioplex_WMM |
| RNF213 | GSDME | 0.009 | 0.105 | bioplex_WMM WMM_only |
| RRP1 | GSDME | 0.008 | 0.061 | bioplex_WMM WMM_only |
| RRP1 | RNF213 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| RNF213 | PTPRD | 0.007 | 0.007 | bioplex_WMM WMM_only |
| RNF213 | PTPRF | 0.007 | 0.006 | bioplex_WMM WMM_only |
| GSDME | PTPRD | 0.007 | 0.007 | bioplex_WMM WMM_only |
| PTPRF | GSDME | 0.007 | 0.003 | bioplex_WMM WMM_only |
| RRP1 | PTPRD | 0.007 | 0.006 | bioplex_WMM WMM_only |
| RRP1 | PTPRF | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PTPRF | PTPRD | 0.006 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06955 has an average edge precision of 0.175 which is ranked 6481 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RNF213 | HuMAP2_00808 HuMAP2_02062 HuMAP2_06955 |
| RRP1 | HuMAP2_00008 HuMAP2_02062 HuMAP2_06955 |
| GSDME | HuMAP2_06955 |
| SCN2B | HuMAP2_00808 HuMAP2_02062 HuMAP2_06955 |
| PTPRF | HuMAP2_02062 HuMAP2_02607 HuMAP2_06955 |
| PTPRD | HuMAP2_06955 |