hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06974

Confidence: Medium

Genename	Protein Name	Links
TMEM258	Transmembrane protein 258 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258) (Oligosaccharyl transferase subunit TMEM258)	UniProt NCBI
EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)	UniProt NCBI
STT3A	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC)	UniProt NCBI
KDSR	3-ketodihydrosphingosine reductase (KDS reductase) (EC 1.1.1.102) (3-dehydrosphinganine reductase) (Follicular variant translocation protein 1) (FVT-1) (Short chain dehydrogenase/reductase family 35C member 1)	UniProt NCBI
MLEC	Malectin	UniProt NCBI
STT3B	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog)	UniProt NCBI
RPN2	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0008250	2.81450928027e-07	0.571428571429	STT3A TMEM258 RPN2 STT3B	oligosaccharyltransferase complex
GO:0005789	1.82778284922e-05	1.0	MLEC TMEM258 STT3B EIF2AK3 STT3A KDSR RPN2	endoplasmic reticulum membrane
GO:0042175	2.04917108173e-05	1.0	MLEC TMEM258 STT3B EIF2AK3 STT3A KDSR RPN2	nuclear outer membrane-endoplasmic reticulum membrane network
KEGG:04141	2.12688843743e-05	0.571428571429	STT3A STT3B EIF2AK3 RPN2	Protein processing in endoplasmic reticulum
KEGG:00513	2.36321422077e-05	0.428571428571	STT3A RPN2 STT3B	Various types of N-glycan biosynthesis
KEGG:00510	4.37646030023e-05	0.428571428571	STT3A RPN2 STT3B	N-Glycan biosynthesis
CORUM:1199	0.000150938581911	0.285714285714	STT3A RPN2	Oligosaccharyltransferase complex (Stt3A variant)
GO:0044432	0.00016536491903	1.0	MLEC TMEM258 STT3B EIF2AK3 STT3A KDSR RPN2	endoplasmic reticulum part
CORUM:1200	0.000211266711219	0.285714285714	RPN2 STT3B	Oligosaccharyltransferase complex (Stt3B variant)
GO:0004579	0.000266683990267	0.428571428571	STT3A RPN2 STT3B	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0004576	0.000380900357231	0.428571428571	STT3A RPN2 STT3B	oligosaccharyl transferase activity
CORUM:6131	0.000452410410067	0.285714285714	STT3A RPN2	SELK multiprotein complex
GO:0006487	0.000688210464691	0.571428571429	STT3A TMEM258 RPN2 STT3B	protein N-linked glycosylation
GO:0005783	0.00203891214571	1.0	MLEC TMEM258 STT3B EIF2AK3 STT3A KDSR RPN2	endoplasmic reticulum
GO:0043686	0.00946729163895	0.285714285714	STT3A STT3B	co-translational protein modification
GO:0034998	0.00946729163895	0.285714285714	TMEM258 STT3B	oligosaccharyltransferase I complex
GO:0018279	0.0128352677703	0.428571428571	STT3A RPN2 STT3B	protein N-linked glycosylation via asparagine
GO:0018196	0.0142076090165	0.428571428571	STT3A RPN2 STT3B	peptidyl-asparagine modification
GO:0006486	0.0335643611827	0.571428571429	STT3A TMEM258 RPN2 STT3B	protein glycosylation
GO:0043413	0.0343259651745	0.571428571429	STT3A TMEM258 RPN2 STT3B	macromolecule glycosylation
REAC:R-HSA-446203	0.0383313102015	0.428571428571	STT3A RPN2 MLEC	Asparagine N-linked glycosylation
GO:0070085	0.0408924264636	0.571428571429	STT3A TMEM258 RPN2 STT3B	glycosylation

Edges

Protein 1	Protein 2	Score	Precision	Evidence
STT3A	RPN2	0.22	0.466	hein_WMM bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
RPN2	EIF2AK3	0.138	0.406	bioplex (RPN2) bioplex_WMM youn_WMM gupta_WMM
RPN2	STT3B	0.137	0.407	hein_WMM bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
RPN2	MLEC	0.136	0.406	hein_WMM bioplex (RPN2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
RPN2	TMEM258	0.105	0.37	bioplex (RPN2) bioplex_WMM
RPN2	KDSR	0.021	0.195	bioplex_WMM Guru boldt fraction boldt_WMM
MLEC	STT3B	0.013	0.149	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
EIF2AK3	TMEM258	0.007	0.005	bioplex_WMM WMM_only
STT3A	TMEM258	0.007	0.001	bioplex_WMM WMM_only
TMEM258	STT3B	0.007	0.001	bioplex_WMM WMM_only
TMEM258	KDSR	0.007	0.002	bioplex_WMM WMM_only
MLEC	TMEM258	0.007	0.004	bioplex_WMM WMM_only
EIF2AK3	KDSR	0.006	0.004	bioplex_WMM WMM_only
STT3A	EIF2AK3	0.006	0.006	bioplex_WMM youn_WMM gupta_WMM WMM_only
EIF2AK3	STT3B	0.006	0.008	bioplex_WMM youn_WMM gupta_WMM WMM_only
MLEC	EIF2AK3	0.005	0.006	bioplex_WMM gupta_WMM WMM_only
STT3A	KDSR	0.005	0.007	bioplex_WMM boldt boldt_WMM
MLEC	KDSR	0.005	0.011	bioplex_WMM boldt boldt_WMM
STT3A	MLEC	0.004	0.014	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
STT3B	KDSR	0.004	0.012	bioplex_WMM boldt boldt_WMM
STT3A	STT3B	0.004	0.009	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM

Images

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Complex HuMAP2_06974 has an average edge precision of 0.119 which is ranked 6878 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TMEM258	HuMAP2_00485 HuMAP2_01092 HuMAP2_02727 HuMAP2_05631 HuMAP2_06974
EIF2AK3	HuMAP2_00485 HuMAP2_01092 HuMAP2_05631 HuMAP2_06974
STT3A	HuMAP2_00485 HuMAP2_01092 HuMAP2_02541 HuMAP2_05631 HuMAP2_06974
KDSR	HuMAP2_01092 HuMAP2_03970 HuMAP2_06380 HuMAP2_06974
MLEC	HuMAP2_00485 HuMAP2_01092 HuMAP2_06974
STT3B	HuMAP2_00851 HuMAP2_00906 HuMAP2_01620 HuMAP2_06974
RPN2	HuMAP2_00485 HuMAP2_01092 HuMAP2_05228 HuMAP2_05631 HuMAP2_06974

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06974