hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06982
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DDOST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) | UniProt NCBI |
| MAGT1 | Magnesium transporter protein 1 (MagT1) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1) (Oligosaccharyl transferase subunit MAGT1) (Implantation-associated protein) (IAP) | UniProt NCBI |
| PGRMC2 | Membrane-associated progesterone receptor component 2 (Progesterone membrane-binding protein) (Steroid receptor protein DG6) | UniProt NCBI |
| SEC61A1 | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) | UniProt NCBI |
| SEC63 | Translocation protein SEC63 homolog | UniProt NCBI |
| JAGN1 | Protein jagunal homolog 1 | UniProt NCBI |
| RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1199 | 6.75899855318e-08 | 0.428571428571 | RPN1 DDOST MAGT1 | Oligosaccharyltransferase complex (Stt3A variant) |
| CORUM:1200 | 1.18258642143e-07 | 0.428571428571 | RPN1 DDOST MAGT1 | Oligosaccharyltransferase complex (Stt3B variant) |
| KEGG:04141 | 2.12688843743e-05 | 0.571428571429 | RPN1 SEC63 DDOST SEC61A1 | Protein processing in endoplasmic reticulum |
| GO:0004579 | 0.000266683990267 | 0.428571428571 | RPN1 DDOST MAGT1 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| GO:0004576 | 0.000380900357231 | 0.428571428571 | RPN1 DDOST MAGT1 | oligosaccharyl transferase activity |
| CORUM:6131 | 0.000452410410067 | 0.285714285714 | RPN1 DDOST | SELK multiprotein complex |
| GO:0008250 | 0.000523632447094 | 0.428571428571 | RPN1 DDOST MAGT1 | oligosaccharyltransferase complex |
| REAC:R-HSA-1799339 | 0.00230723415657 | 0.428571428571 | RPN1 DDOST SEC61A1 | SRP-dependent cotranslational protein targeting to membrane |
| KEGG:03060 | 0.00249893990045 | 0.285714285714 | SEC61A1 SEC63 | Protein export |
| KEGG:00513 | 0.00620456314068 | 0.285714285714 | RPN1 DDOST | Various types of N-glycan biosynthesis |
| KEGG:00510 | 0.0093000092131 | 0.285714285714 | RPN1 DDOST | N-Glycan biosynthesis |
| GO:0018279 | 0.0128352677703 | 0.428571428571 | RPN1 DDOST MAGT1 | protein N-linked glycosylation via asparagine |
| GO:0018196 | 0.0142076090165 | 0.428571428571 | RPN1 DDOST MAGT1 | peptidyl-asparagine modification |
| HP:0001871 | 0.0146227805424 | 0.714285714286 | MAGT1 SEC61A1 JAGN1 DDOST SEC63 | Abnormality of blood and blood-forming tissues |
| REAC:R-HSA-446203 | 0.0383313102015 | 0.428571428571 | RPN1 DDOST MAGT1 | Asparagine N-linked glycosylation |
| GO:0005791 | 0.0389125948999 | 0.428571428571 | RPN1 SEC63 SEC61A1 | rough endoplasmic reticulum |
| HP:0002719 | 0.0401892786968 | 0.571428571429 | MAGT1 SEC61A1 JAGN1 DDOST | Recurrent infections |
| REAC:R-HSA-72766 | 0.0403505818332 | 0.428571428571 | RPN1 DDOST SEC61A1 | Translation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DDOST | RPN1 | 0.339 | 0.528 | hein_WMM bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| MAGT1 | DDOST | 0.205 | 0.454 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC61A1 | DDOST | 0.087 | 0.353 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RPN1 | PGRMC2 | 0.039 | 0.264 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| JAGN1 | DDOST | 0.029 | 0.232 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SEC61A1 | SEC63 | 0.028 | 0.231 | bioplex (SEC63) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| MAGT1 | SEC61A1 | 0.026 | 0.22 | bioplex (SEC61A1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| JAGN1 | SEC61A1 | 0.026 | 0.22 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| JAGN1 | PGRMC2 | 0.007 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| MAGT1 | JAGN1 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| JAGN1 | RPN1 | 0.007 | 0.005 | youn_WMM gupta_WMM WMM_only |
| JAGN1 | SEC63 | 0.007 | 0.0 | youn_WMM gupta_WMM WMM_only |
| DDOST | PGRMC2 | 0.007 | 0.005 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC61A1 | PGRMC2 | 0.005 | 0.009 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC63 | RPN1 | 0.005 | 0.008 | bioplex (SEC63) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| MAGT1 | PGRMC2 | 0.005 | 0.01 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC63 | DDOST | 0.004 | 0.017 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SEC61A1 | RPN1 | 0.003 | 0.021 | bioplex (SEC61A1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MAGT1 | RPN1 | 0.003 | 0.005 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MAGT1 | SEC63 | 0.003 | 0.011 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SEC63 | PGRMC2 | 0.0 | 0.009 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_06982 has an average edge precision of 0.124 which is ranked 6854 out of all 6965 complexes.
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