hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06986
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAC1 | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1) | UniProt NCBI |
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (p21-Rac3) | UniProt NCBI |
| RAC2 | Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2290 | 1.41702742731e-08 | 1.0 | RAC2 RAC3 RAC1 | RalA downstream regulated genes |
| WP:WP3937 | 2.61505970677e-07 | 1.0 | RAC2 RAC3 RAC1 | Microglia Pathogen Phagocytosis Pathway |
| KEGG:05416 | 4.56498670209e-07 | 1.0 | RAC2 RAC3 RAC1 | Viral myocarditis |
| KEGG:04664 | 7.88948788731e-07 | 1.0 | RAC2 RAC3 RAC1 | Fc epsilon RI signaling pathway |
| KEGG:04370 | 7.88948788731e-07 | 1.0 | RAC2 RAC3 RAC1 | VEGF signaling pathway |
| KEGG:04662 | 1.44061718026e-06 | 1.0 | RAC2 RAC3 RAC1 | B cell receptor signaling pathway |
| KEGG:04520 | 1.57561207687e-06 | 1.0 | RAC2 RAC3 RAC1 | Adherens junction |
| KEGG:05212 | 1.7187866598e-06 | 1.0 | RAC2 RAC3 RAC1 | Pancreatic cancer |
| KEGG:05210 | 2.66320963331e-06 | 1.0 | RAC2 RAC3 RAC1 | Colorectal cancer |
| KEGG:05231 | 3.41513932698e-06 | 1.0 | RAC2 RAC3 RAC1 | Choline metabolism in cancer |
| WP:WP4216 | 3.68137284582e-06 | 1.0 | RAC2 RAC3 RAC1 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:04650 | 4.71682212935e-06 | 1.0 | RAC2 RAC3 RAC1 | Natural killer cell mediated cytotoxicity |
| WP:WP4263 | 5.91808622949e-06 | 1.0 | RAC2 RAC3 RAC1 | Pancreatic adenocarcinoma pathway |
| KEGG:04071 | 6.31321421816e-06 | 1.0 | RAC2 RAC3 RAC1 | Sphingolipid signaling pathway |
| KEGG:05135 | 6.85409597589e-06 | 1.0 | RAC2 RAC3 RAC1 | Yersinia infection |
| WP:WP185 | 8.35827186966e-06 | 1.0 | RAC2 RAC3 RAC1 | Integrin-mediated Cell Adhesion |
| KEGG:05418 | 9.55549752694e-06 | 1.0 | RAC2 RAC3 RAC1 | Fluid shear stress and atherosclerosis |
| KEGG:04062 | 1.07586932974e-05 | 1.0 | RAC2 RAC3 RAC1 | Chemokine signaling pathway |
| WP:WP710 | 1.17293801192e-05 | 1.0 | RAC2 RAC3 RAC1 | DNA Damage Response (only ATM dependent) |
| KEGG:04310 | 1.55974889844e-05 | 1.0 | RAC2 RAC3 RAC1 | Wnt signaling pathway |
| KEGG:04360 | 2.21071058913e-05 | 1.0 | RAC2 RAC3 RAC1 | Axon guidance |
| WP:WP51 | 2.41319770871e-05 | 1.0 | RAC2 RAC3 RAC1 | Regulation of Actin Cytoskeleton |
| KEGG:04024 | 2.41914222835e-05 | 1.0 | RAC2 RAC3 RAC1 | cAMP signaling pathway |
| KEGG:04015 | 2.55027583186e-05 | 1.0 | RAC2 RAC3 RAC1 | Rap1 signaling pathway |
| KEGG:04014 | 3.07154438585e-05 | 1.0 | RAC2 RAC3 RAC1 | Ras signaling pathway |
| KEGG:04810 | 3.2250969458e-05 | 1.0 | RAC2 RAC3 RAC1 | Regulation of actin cytoskeleton |
| KEGG:04510 | 3.33025703802e-05 | 1.0 | RAC2 RAC3 RAC1 | Focal adhesion |
| KEGG:05170 | 3.89046029743e-05 | 1.0 | RAC2 RAC3 RAC1 | Human immunodeficiency virus 1 infection |
| WP:WP4223 | 3.92056063451e-05 | 1.0 | RAC2 RAC3 RAC1 | Ras Signaling |
| KEGG:05163 | 4.06999539039e-05 | 1.0 | RAC2 RAC3 RAC1 | Human cytomegalovirus infection |
| REAC:R-HSA-4086400 | 5.46192807335e-05 | 1.0 | RAC2 RAC3 RAC1 | PCP/CE pathway |
| WP:WP306 | 7.01967046941e-05 | 1.0 | RAC2 RAC3 RAC1 | Focal Adhesion |
| KEGG:04010 | 8.31056129839e-05 | 1.0 | RAC2 RAC3 RAC1 | MAPK signaling pathway |
| WP:WP382 | 0.000111215333222 | 1.0 | RAC2 RAC3 RAC1 | MAPK Signaling Pathway |
| REAC:R-HSA-194840 | 0.00016461766098 | 1.0 | RAC2 RAC3 RAC1 | Rho GTPase cycle |
| REAC:R-HSA-3858494 | 0.000188480017032 | 1.0 | RAC2 RAC3 RAC1 | Beta-catenin independent WNT signaling |
| KEGG:05200 | 0.000500689425538 | 1.0 | RAC2 RAC3 RAC1 | Pathways in cancer |
| REAC:R-HSA-5668599 | 0.00114404160216 | 0.666666666667 | RAC2 RAC1 | RHO GTPases Activate NADPH Oxidases |
| KEGG:04666 | 0.0017077231529 | 0.666666666667 | RAC2 RAC1 | Fc gamma R-mediated phagocytosis |
| KEGG:04670 | 0.0017077231529 | 0.666666666667 | RAC2 RAC1 | Leukocyte transendothelial migration |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | RAC2 RAC3 RAC1 | Signaling by WNT |
| REAC:R-HSA-114604 | 0.00252791438215 | 0.666666666667 | RAC2 RAC1 | GPVI-mediated activation cascade |
| WP:WP4298 | 0.00265307790854 | 0.666666666667 | RAC2 RAC3 | Viral Acute Myocarditis |
| WP:WP23 | 0.00365767654025 | 0.666666666667 | RAC2 RAC1 | B Cell Receptor Signaling Pathway |
| REAC:R-HSA-194315 | 0.00591618280835 | 1.0 | RAC2 RAC3 RAC1 | Signaling by Rho GTPases |
| REAC:R-HSA-2219530 | 0.00661568366637 | 0.666666666667 | RAC2 RAC1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP3929 | 0.00727489926623 | 0.666666666667 | RAC2 RAC1 | Chemokine signaling pathway |
| WP:WP481 | 0.0112234268693 | 0.666666666667 | RAC2 RAC1 | Insulin Signaling |
| GO:0005884 | 0.0133902908488 | 1.0 | RAC2 RAC3 RAC1 | actin filament |
| GO:0008360 | 0.0146853637429 | 1.0 | RAC2 RAC3 RAC1 | regulation of cell shape |
| REAC:R-HSA-6811558 | 0.015660289467 | 0.666666666667 | RAC2 RAC1 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 0.0165866686159 | 0.666666666667 | RAC2 RAC1 | PI3K/AKT Signaling in Cancer |
| GO:0007266 | 0.0180261250619 | 1.0 | RAC2 RAC3 RAC1 | Rho protein signal transduction |
| REAC:R-HSA-199418 | 0.0190186686906 | 0.666666666667 | RAC2 RAC1 | Negative regulation of the PI3K/AKT network |
| GO:0010810 | 0.0302766427817 | 1.0 | RAC2 RAC3 RAC1 | regulation of cell-substrate adhesion |
| WP:WP3943 | 0.0357037760272 | 0.333333333333 | RAC1 | Robo4 and VEGF Signaling Pathways Crosstalk |
| GO:0060263 | 0.0486736709081 | 0.666666666667 | RAC2 RAC1 | regulation of respiratory burst |
| GO:0010310 | 0.0486736709081 | 0.666666666667 | RAC2 RAC1 | regulation of hydrogen peroxide metabolic process |
| WP:WP4146 | 0.0499785733994 | 0.333333333333 | RAC2 | Macrophage markers |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAC3 | RAC2 | 0.94 | 0.852 | bioplex (RAC2) bioplex_WMM |
| RAC3 | RAC1 | 0.171 | 0.43 | bioplex (RAC1) bioplex_WMM |
Images
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Complex HuMAP2_06986 has an average edge precision of 0.641 which is ranked 1714 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAC1 | HuMAP2_00873 HuMAP2_04052 HuMAP2_04080 HuMAP2_04419 HuMAP2_06986 |
| RAC3 | HuMAP2_00873 HuMAP2_04052 HuMAP2_04080 HuMAP2_04861 HuMAP2_06986 |
| RAC2 | HuMAP2_00873 HuMAP2_04052 HuMAP2_04080 HuMAP2_04861 HuMAP2_06986 |