hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06990
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HSPB8 | Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22) | UniProt NCBI |
| RPTOR | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) | UniProt NCBI |
| CASP3 | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | UniProt NCBI |
| BAG3 | BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) | UniProt NCBI |
| HSPB6 | Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6052 | 4.0241279111e-05 | 0.4 | HSPB8 BAG3 | BAG3-HSC70-HSPB8-CHIP complex |
| REAC:R-HSA-3371556 | 0.000266353842167 | 0.6 | HSPB8 RPTOR BAG3 | Cellular response to heat stress |
| GO:0016241 | 0.00207968006832 | 0.8 | HSPB8 BAG3 RPTOR CASP3 | regulation of macroautophagy |
| REAC:R-HSA-3371571 | 0.00340529843133 | 0.4 | HSPB8 RPTOR | HSF1-dependent transactivation |
| WP:WP1772 | 0.0107054175474 | 0.4 | CASP3 BAG3 | Apoptosis Modulation and Signaling |
| GO:1905335 | 0.0135228859698 | 0.4 | HSPB8 BAG3 | regulation of aggrephagy |
| GO:1905337 | 0.0135228859698 | 0.4 | HSPB8 BAG3 | positive regulation of aggrephagy |
| GO:0016236 | 0.0210321541014 | 0.8 | HSPB8 BAG3 RPTOR CASP3 | macroautophagy |
| GO:0010506 | 0.0234344442687 | 0.8 | HSPB8 BAG3 RPTOR CASP3 | regulation of autophagy |
| REAC:R-HSA-2262752 | 0.0291077226575 | 0.6 | HSPB8 RPTOR BAG3 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | HSPB8 RPTOR BAG3 | Cellular responses to external stimuli |
| CORUM:2985 | 0.0499494897235 | 0.2 | RPTOR | mTOR complex (MTOR, RAPTOR) |
| CORUM:2991 | 0.0499494897235 | 0.2 | RPTOR | mTOR complex (MTOR, RAPTOR) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BAG3 | HSPB8 | 0.349 | 0.536 | hein_WMM bioplex (HSPB8) bioplex_WMM hein (BAG3) gupta_WMM |
| RPTOR | BAG3 | 0.057 | 0.321 | bioplex (RPTOR) bioplex_WMM youn_WMM |
| CASP3 | BAG3 | 0.053 | 0.301 | fraction |
| HSPB6 | BAG3 | 0.053 | 0.301 | bioplex (HSPB6) bioplex_WMM gupta_WMM |
Images
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Complex HuMAP2_06990 has an average edge precision of 0.365 which is ranked 3693 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HSPB8 | HuMAP2_00689 HuMAP2_03772 HuMAP2_06990 |
| RPTOR | HuMAP2_00689 HuMAP2_06990 |
| CASP3 | HuMAP2_00689 HuMAP2_06203 HuMAP2_06990 |
| BAG3 | HuMAP2_00689 HuMAP2_06990 |
| HSPB6 | HuMAP2_00689 HuMAP2_02613 HuMAP2_05639 HuMAP2_06990 |